Clinical Outcomes after Hepatitis C Infection from Contaminated Anti-D Immune Globulin

Kenny-Walsh, Elizabeth

doi:10.1056/nejm199904223401602

Cited by 855 publications

(616 citation statements)

References 29 publications

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“…56 The viral strain of the infecting inoculum and the dose were consistent in this outbreak. An association has been reported for HLA-DRB1*0101 with self-limiting infection in this cohort.…”

Section: Susceptibility To Persistent Hcv Infectionmentioning

confidence: 70%

Host genetic determinants in hepatitis C virus infection

2004

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In addition to viral and environmental/behavioural factors, host genetic diversity is believed to contribute to the spectrum of clinical outcomes in hepatitis C virus (HCV) infection. This paper reviews the literature with respect to studies of host genetic determinants of HCV outcome and attempts to highlight trends and synthesise findings. With respect to the susceptibility to HCV infection, several studies have replicated associations of the HLA class II alleles DQB1*0301 and DRB1*11 with selflimiting infection predominantly in Caucasian populations. Meta-analyses yielded summary estimates of 3.0 (95% CI: 1.8-4.8) and 2.5 (95% CI: 1.7-3.7) for the effects of DQB1*0301 and DRB1*11 on self-limiting HCV, respectively. Studies of genetics and the response to interferon-based therapies have largely concerned single-nucleotide polymorphisms and have been inconsistent. Regarding studies of genetics and the progression of HCV-related disease, there is a trend with DRB1*11 alleles and less severe disease. Studies of extrahepatic manifestations of chronic HCV have shown an association between DQB1*11 and DR3 with the formation of cryoglobulins. Some important initial observations have been made with respect to genetic determinants of HCV outcome. Replication studies are needed for many of these associations, as well as biological data on the function of many of these polymorphisms.

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Section: Susceptibility To Persistent Hcv Infectionmentioning

confidence: 70%

Host genetic determinants in hepatitis C virus infection

2004

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“…Even when a large number of persons have been accidentally infected by the same viral inoculum, some recover while others develop viral persistence. 5,6 In addition, recovery from HCV infection occurs more often in Caucasians than African Americans, even after adjusting for environmental and viral factors. 7 Some host genetic polymorphisms in the human leukocyte antigen complex have been associated with HCV recovery.…”

Section: Introductionmentioning

confidence: 99%

MICA and recovery from hepatitis C virus and hepatitis B virus infections

et al. 2004

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The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8 þ T cells and natural killer (NK) cells. We hypothesized that MICA heterogeneity would affect recovery from hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To test the hypothesis, we initially typed known MICA polymorphisms for 228 persons who cleared HCV infection and 442 persons with persistent hepatitis C matched on other factors affecting viral persistence. Although MICA*015 was detected more than two-fold more often in persons with viral clearance (odds ratio 0.36, 95% confidence interval ¼ 0.19, 0.80), it occurred in fewer than 5% of the study population. In a similar analysis of 442 persons with chronic hepatitis B and 768 matched controls who recovered, MICA*015 was detected in 2.0% of persons with chronic hepatitis B and only 0.9% of controls. No significant associations were detected with other MICA polymorphisms. While further investigation may reveal a structural basis of the MICA*015 associations, these data provide little support for the hypothesis that differential distribution of MICA alleles substantially affects recovery from HCV and HBV infections.

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“…The risk of serious illness from liver disease increases with age [2]. There are few longitudinal studies on HCV-induced liver fibrosis with established time-point of HCV exposure, and the great majority have been performed among patients infected through medical procedures such as transfusions and medical injections with infected syringes or sera containing HCV [3][4][5][6][7]. In Western countries the main cause of HCV-infection has been the use of contaminated syringes and needles among IDUs.…”

Section: Hepatitis C Virus (Hcv) Infection Has Been Endemic Among Injmentioning

confidence: 99%

Liver fibrosis progression at autopsy in injecting drug users infected by hepatitis C: A longitudinal long-term cohort study

Kielland

Delaveris

Rogde

et al. 2014

Journal of Hepatology

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Clinical Outcomes after Hepatitis C Infection from Contaminated Anti-D Immune Globulin

Abstract: Most of the women with HCV infection 17 years after receiving HCV-contaminated anti-D immune globulin had evidence of slight or moderate hepatic inflammation on liver biopsy, about half had fibrosis, and 2 percent had probable or definite cirrhosis.

Cited by 855 publications

References 29 publications

Host genetic determinants in hepatitis C virus infection

Host genetic determinants in hepatitis C virus infection

MICA and recovery from hepatitis C virus and hepatitis B virus infections

Liver fibrosis progression at autopsy in injecting drug users infected by hepatitis C: A longitudinal long-term cohort study

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