Clinical outcome of surgically treated low-grade gliomas: A retrospective analysis of a single institute

Türkoğlu, Erhan; Gürer, Bora; Şanlı, Ahmet Metin; Dolgun, Habibullah; Gürses, Levent; Oral, Nezih; Dönmez, Turgut; Şekerci, Zeki

doi:10.1016/j.clineuro.2013.10.010

Cited by 15 publications

(11 citation statements)

References 27 publications

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“…Consistent with this observation, we found that the risk of recurrence is significantly lower in patients with GTR in comparison to STR and/ or biopsy only (23,26,27). The majority of patients with STR in our cohort underwent adjuvant chemotherapy, and in a subset of cases, when local control could not be achieved, radiation therapy as well (28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Whole Chromosome 7 Gain Predicts Higher Risk of Recurrence in Pediatric Pilocytic Astrocytomas Independently From KIAA1549-BRAF Fusion Status

Roth

Fierst

Waanders

et al. 2016

J Neuropathol Exp Neurol

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The most frequent genetic alteration identified in pediatric pilocytic astrocytomas and pilomyxoid variant is the KIAA1549-BRAF fusion, which typically results from a 2.0 Mb tandem duplication in chromosome band 7q34. Less frequent abnormalities include fusion genes,BRAF, FGFR, KRAS, and NF1 point mutations, and whole chromosome gains. To correlate genetic alterations with clinical course data, we retrospectively analyzed the tumors with pilocytic and pilomyxoid histology of a cohort of 116 pediatric patients, aged 5 months to 23 years. Gross total resection was associated with a decreased risk of recurrence (p = 0.001), supporting previous findings that complete tumor excision correlates with long-term and disease-free survival. We found no significant association between recurrence rate and the presence of the KIAA1549-BRAF fusion or BRAF mutation (p = 0.167). Interestingly, gain of whole chromosome 7 (WC7) was associated with a 4.7-fold increased risk of tumor recurrence, even after adjusting for surgical status (p = 0.025), and other genetic alterations. Using fluorescence in situ hybridization, we demonstrated that when WC7 gain accompanies the KIAA1549-BRAF fusion, the fusion likely arises first. This study highlights the utility of genetic studies for risk assessment of pilocytic and pilomyxoid astrocytomas, which may impact treatment selections.

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Section: Discussionmentioning

confidence: 99%

Whole Chromosome 7 Gain Predicts Higher Risk of Recurrence in Pediatric Pilocytic Astrocytomas Independently From KIAA1549-BRAF Fusion Status

Roth

Fierst

Waanders

et al. 2016

J Neuropathol Exp Neurol

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“…Improved outcomes were seen for patients who underwent resection over biopsy, which is in line with prior analyses [16]. Advancements in surgery may allow for a greater extent of resection, which leads to improved survival [20,21]. The presence of midline shift at diagnosis correlated with improved survival although only 3 patients had midline shift so this findings is questionable.…”

Section: Discussionmentioning

confidence: 41%

Prognosis of older patients with low-grade glioma: A retrospective study

Kumthekar¹,

Patel²,

Bridge³

et al. 2017

Integr Cancer Sci Therap

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“…5 Partial resection is usually followed by radiotherapy, whereas radiation therapy after radical resection may be used if there is tumor recurrence. 9 There are emerging data that suggest chemotherapy may have a beneficial effect on disease course if initiated early. 8 In our patient, several diagnostic challenges were encountered.…”

Section: Discussionmentioning

confidence: 99%

Second chances

Nagia

Doyle

Hackney

et al. 2015

Survey of Ophthalmology

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An 81-year-old woman presented with light perception vision in her left eye and had pallid swelling of the left optic disk. Temporal artery biopsy was normal. Magnetic resonance imaging revealed enlargement and enhancement of the left orbital optic nerve. There were vitreous cells, but a vitrectomy specimen showed only a benign lymphocytic population. Her vision deteriorated to no light perception in the left eye, and an optic nerve biopsy revealed a diffuse astrocytoma of World Health Organization grade II.

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Clinical outcome of surgically treated low-grade gliomas: A retrospective analysis of a single institute

Cited by 15 publications

References 27 publications

Whole Chromosome 7 Gain Predicts Higher Risk of Recurrence in Pediatric Pilocytic Astrocytomas Independently From KIAA1549-BRAF Fusion Status

Whole Chromosome 7 Gain Predicts Higher Risk of Recurrence in Pediatric Pilocytic Astrocytomas Independently From KIAA1549-BRAF Fusion Status

Prognosis of older patients with low-grade glioma: A retrospective study

Second chances

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