Clinical outcome of supracricoid laryngectomy with cricohyoidoepiglottopexy: Radiation failure versus previously untreated patients

Nakayama, Meijin; Okamoto, Makito; Hayakawa, Kazushige; Ishiyama, Hiromichi; Kotani, Shouko; Miyamoto, Shunsuke; Seino, Yutomo; Okamoto, Tabito; Soda, Itaru; Sekiguchi, Akane

doi:10.1016/j.anl.2012.07.014

Cited by 27 publications

(39 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our experience with 100 SCL-CHEP patients convinced us of the clinical potential of SCL-CHEP as one of the effective options for functional larynx preservation. SCL-CHEP is the most suitable for unfavorable T2 and T3a cases and is applicable for appropriately selected radiation-failed patients (28). Thorough pre-operative evaluation, proper surgical techniques and careful follow-up are prerequisites for the success of SCL-CHEP.…”

Section: Discussionmentioning

confidence: 99%

One hundred supracricoid laryngectomies with cricohyoidoepiglottopexy: do we achieve better local control?

Nakayama

Miyamoto

Seino

et al. 2015

Jpn. J. Clin. Oncol.

Self Cite

View full text Add to dashboard Cite

Objective: Supracricoid laryngectomy with cricohyoidoepiglottopexy has been known to be able to cope with tumor excisions with minimal margins. Extended resection may result in a limited margin and may impair the prognosis. We conducted a clinicopathologic analysis of local recurrence in supracricoid laryngectomy with cricohyoidoepiglottopexy patients. Methods: Between 1997 and 2013, 100 patients with glottic cancers underwent supracricoid laryngectomy with cricohyoidoepiglottopexy. The clinicopathologic findings were evaluated. We also analyzed: (i) cancer-specific and overall survival rates, (ii) the correlation between locoregional recurrence and overall survival, (iii) T staging and larynx preservation rates and (iv) previous radiation history and larynx preservation rates. Results: Local recurrence was recognized in eight of the 100 patients (8%); all were initially staged as T3 or T4. Recurrence was identified in the submucosal regions of the ipsilateral arytenoid and/or infraglottis. Six patients were salvaged by completion total laryngectomy except two. Cancer-specific survival at 5 years was 93%; overall survival at 5 years was 89%. There was no significant difference between overall survival and locoregional recurrence. There was a significant difference between larynx preservation in T1-2 and T3-4 patients. There was no significant difference between larynx preservation and the previous radiation therapy status. Conclusions: Our experience convinced us of the clinical potential of supracricoid laryngectomy with cricohyoidoepiglottopexy as one of the effective options for functional larynx preservation. Supracricoid laryngectomy with cricohyoidoepiglottopexy is the most suitable for unfavorable T2 and T3a cases and is applicable for appropriately selected radiation-failed patients. Thorough preoperative evaluation, proper surgical techniques and careful follow-up are prerequisites for the success of supracricoid laryngectomy with cricohyoidoepiglottopexy.

show abstract

Section: Discussionmentioning

confidence: 99%

One hundred supracricoid laryngectomies with cricohyoidoepiglottopexy: do we achieve better local control?

Nakayama

Miyamoto

Seino

et al. 2015

Jpn. J. Clin. Oncol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In our institute, both oncological and functional outcomes have been satisfactory and did not vary between patients undergoing primary and salvage surgery. 9 Salvage supracricoid laryngectomy with cricohyoidoepiglottopexy is applicable to all recurrent tumour stages and is the most effective for unfavourable T 2 and T 3a tumours. 9 Despite this positive evidence, the application of salvage supracricoid laryngectomy with cricohyoidoepiglottopexy after RT and vertical partial laryngectomy failure was unprecedented.…”

Section: Discussionmentioning

confidence: 99%

“…9 Salvage supracricoid laryngectomy with cricohyoidoepiglottopexy is applicable to all recurrent tumour stages and is the most effective for unfavourable T 2 and T 3a tumours. 9 Despite this positive evidence, the application of salvage supracricoid laryngectomy with cricohyoidoepiglottopexy after RT and vertical partial laryngectomy failure was unprecedented. A final decision to use this surgical procedure was based on clinical evaluations, including targeted CT imaging and a patient interview.…”

Section: Discussionmentioning

confidence: 99%

Salvage supracricoid laryngectomy after failed radiotherapy and partial laryngectomy

et al. 2014

View full text Add to dashboard Cite

Appropriate case selection and proficient surgical skills were essential for a successful outcome. Head and neck surgeons should not be afraid to adopt functional preservation open surgical procedures in well-selected and well-motivated patients. A requirement for more challenging surgical procedures and meticulous rehabilitation processes should not exclude appropriate treatments from a surgeon's repertoire.

show abstract

“…SCL-CHEP can also be utilized as a salvage surgery following failure of CCRT or RT; the oncologic and functional outcomes were comparable between irradiated and non-irradiated patients (25). Laser has only been utilized for early-stage cancers at our institute, but has been reported to be useful for the treatment of advanced stage cancers with successful results in some experienced institutes (26,27).…”

Section: Surgical Optionsmentioning

confidence: 93%

“…Our treatment criterion can be found in the previous report (25). We advocate RT and laser for T1a, S1RT for T1b and T2 favorable, platinum-based CCRT or SCL for T2 unfavorable, SCL for T3a and TL for T3b and T4 cancers.…”

Section: Surgical Optionsmentioning

confidence: 99%

Clinical Outcomes of 849 Laryngeal Cancers Treated in the Past 40 Years: Are We Succeeding?

Nakayama

Okamoto

Hayakawa

et al. 2013

Japanese Journal of Clinical Oncology

View full text Add to dashboard Cite

Objective: We analyzed the clinical outcomes of 849 laryngeal cancers treated in the past 40 years, which overlapped with the era of the global treatment shift. Methods: To compare the chronological outcomes, patients were divided into four groups according to their registration year as 1972 -82, 1983 -92, 1993 -2002 and 2003 -12; treatment trends, larynx preservation rate and overall survival rate were compared. Results: There were 104, 173, 253 and 319 patients registered in 1972 -82, 1983 -92, 1993 -2002 and 2003 -12, respectively. Five-year overall survival rates were 74, 76.5, 75.6 and 82.2% in 1972 -82, 1983 -92, 1993 -2002 and 2003 -12, respectively. The five-year larynx preservation rates were 65.5, 75.7, 75.4 and 80.9% in 1972 -82, 1983 -92, 1993 -2002 and 2003 -12, respectively. Conclusions: The number of patients treated at our institute increased, and the overall survival and larynx preservation rates exhibited favorable improvements over the past four decades. In the analysis of nonsurgical options, S1 combined radiotherapy showed superiority over concurrent chemoradiotherapy and radiotherapy in larynx preservation, and S1 combined radiotherapy, concurrent chemoradiotherapy and Tegafur Uracil combined radiotherapy showed superiority over radiotherapy in overall survival. In nonsurgical approaches, proper case selection is the key to success and may be much more important than pursuing radiotherapy dose escalation. In the analysis of surgical options, laser and supracricoid laryngectomy with cricohyoidoepiglottopexy contributed to larynx preservation in early-and intermediate-stage cancers, respectively. Supracricoid laryngectomy with cricohyoidoepiglottopexy demonstrated overall survival not worse than total laryngectomy, which is the prerequisite treatment basis for larynx preservation options. We must make extra efforts in pursuing an ideal balance between nonsurgical and surgical larynx preservation options.

show abstract

Clinical outcome of supracricoid laryngectomy with cricohyoidoepiglottopexy: Radiation failure versus previously untreated patients

Cited by 27 publications

References 28 publications

One hundred supracricoid laryngectomies with cricohyoidoepiglottopexy: do we achieve better local control?

One hundred supracricoid laryngectomies with cricohyoidoepiglottopexy: do we achieve better local control?

Salvage supracricoid laryngectomy after failed radiotherapy and partial laryngectomy

Clinical Outcomes of 849 Laryngeal Cancers Treated in the Past 40 Years: Are We Succeeding?

Contact Info

Product

Resources

About