Clinical Outcome of Patients With Malignant Tumors Associated With Mature Cystic Teratomas of the Ovary: A Retrospective Multicenter Italian Study

Abstract

Background/Aim: The aim of the study was to assess the clinical outcome of patients with malignant transformation of an ovarian mature teratoma. Patients and Methods: This study was conducted on 23 patients who underwent primary surgery at three Italian Gynecological Centers. Histologically, nine (39.1%) patients had squamous cell carcinoma, five (21.7%) had a thyroid carcinoma, six (26.1%) had a carcinoid, one (4.3%) patient had papillary renal carcinoma, one (4.3%) had medulloblastoma and one (4.3%) had intestinal-type mucinous adenocarcinoma. Results: All six patients with stage I squamous cell carcinoma had no evidence of disease (NED) after a median time of 141 months. Of the three patients with stage IIb-IIIc squamous cell carcinoma, two had NED after 119 and 154 months, and one died of the disease 9 months after diagnosis. All five women with stage I thyroid carcinoma had NED after a median of 60 months. Of the six patients with stage I carcinoid, five had NED after a median of 168 months, whereas one died due to carcinoid heart disease. The three patients with stage I renal carcinoma, medulloblastoma and mucinous adenocarcinoma had NED after 24, 141 and 149 months, respectively. Conclusion: The clinical outcome of early-stage malignancies associated with mature ovarian teratomas is excellent following treatment.

Incidental diagnosis of squamous cell carcinoma transformation in mature cystic teratoma of the ovary: A case report and review of literature

“…Patients with stage I disease was found to have a significantly better prognosis than stages II, III and IV. 3 , 12 As our patient is 62 years with good performance status, well-differentiated SCC and FIGO stage 1A disease, her survival status can be confirmed upon long-term follow-up only.…”

“… 4 In a retrospective multicenter Italian study, the other histological variants seen were thyroid carcinoma, carcinoid, papillary renal cell carcinoma, medulloblastoma and intestinal-type mucinous adenocarcinoma. 12 The etiology of SCC transformation in MCTO is unknown. SCC transformation in MCTO may be due to a continuous process of squamous metaplasia, atypical hyperplasia, carcinoma in situ, interstitial infiltration and invasive cancer.…”

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

“…Operation played a pivotal role during both diagnosis and treatment. Patients who received optimal cytoreduction followed with adjuvant chemotherapy seem to have a good outcome with longer survival [8,9]. Optimal cytoreduction can bring a mean survival of 14 months while 7.8 months in suboptimal cases [10].…”

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

“…Patients who received optimal cytoreduction followed with adjuvant chemotherapy seem to have a good outcome with longer survival. [8,9] Optimal cytoreduction can bring a mean survival of 14 months while 7.8 months in suboptimal cases. [10] Kikkawa et al [6] reported a 79% 5-year-survival rate for patients without residual disease compared with 10.1% for those with residual disease.…”