Clinical outcome of patients examined by capsule endoscopy for suspected small bowel Crohn's disease

Girelli, C.M.; Porta, P.; Malacrida, V.; Barzaghi, F.; Rocca, Francesco La

doi:10.1016/j.dld.2006.10.018

Cited by 57 publications

(32 citation statements)

References 27 publications

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“…CE has shown great NPV in IBD (35), being a good tool to rule out the disease, but the rate of positive CE in this indication in the literature is only between 26-52.4% (32,36,37). These data need to be improved, especially when compared to the rate of positive CE in cases of MGIB found in the literature, which is 47-84% (38-40).…”

Section: In Capsule Endoscopy In Suspected Small Bowel Crohn's Diseasementioning

confidence: 84%

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Valenzuela¹,

López²,

Fernández³

et al. 2016

Rev Esp Enferm Dig

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Background and aims:Capsule endoscopy is an extended tool for the diagnosis of small bowel Crohn's disease. However, factors associated with positive findings of this technique have not been well established. Our aim is to asses which factors are associated with a better diagnostic yield of capsule endoscopy in suspected small bowel Crohn's disease.Material and methods: This was a retrospective study including patients under capsule endoscopy because of suspected small bowel Crohn's disease. Demographic data of these patients, as well as symptoms and laboratory data including hemoglobin levels, count of leucocytes and platelets, and levels of C-reactive protein, erythrocyte sedimentation rate and fecal calprotectin were collected. Capsule endoscopy studies were classified as negative (no lesions) or positive (lesions suggestive of Crohn's disease). Descriptive, univariate and multivariate analysis were done, as well as diagnostic yield tests of the different markers for predicting lesions in capsule studies.Results: One hundred and twenty-four patients were included (85 women and 39 men). The average age was 38.21 years. Levels of C-reactive protein and fecal calprotectin were the markers more frequently associated with positive findings in capsule endoscopy. Calprotectin presented the best sensitivity as isolated marker. The association of altered levels of C-reactive protein and calprotectin showed the best specificity and predictive values.Conclusions: C-reactive protein and fecal calprotectin are appropriate biomarkers for selecting patients with suspected Crohn's disease of the small bowel for capsule endoscopy studies.

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Section: In Capsule Endoscopy In Suspected Small Bowel Crohn's Diseasementioning

confidence: 84%

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Valenzuela¹,

López²,

Fernández³

et al. 2016

Rev Esp Enferm Dig

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“…Capsule enteroscopy is a recently developed technique that enables direct examination of the entire length of the small intestine; this examination is considered the gold standard for the diagnosis of Crohn disease of the intestine (4,5). Capsule enteroscopy has provided additional information on NSAID-induced intestinal pathology other than Crohn disease.…”

mentioning

confidence: 99%

PET and Macro- and Microautoradiographic Studies Combined with Immunohistochemistry for Monitoring Rat Intestinal Ulceration and Healing Processes

Yamato

Kataoka²,

Mizuma³

et al. 2009

J Nucl Med

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18 F-FDG PET is used mainly in clinical settings for imaging focal cancer sites, but the usefulness of the modality in imaging gastrointestinal ulcers has not been established. We investigated whether PET can be used for noninvasive monitoring of indomethacin-induced small-intestine ulceration. Methods: Intestinal ulcers were induced in rats by subcutaneous administration of indomethacin. An 18 F-FDG PET scan was obtained at 1, 2, and 7 d after indomethacin administration. 18 F-FDG uptake in the small intestine was quantified by g-counting, and macro-and microautoradiographic studies were performed to determine the site of 18 F-FDG uptake in tissue and at the cellular level. Results: Ulcers observed in the intestine (mainly in the ileum) 1-4 d after indomethacin administration were most severe at 1 d after administration and were almost healed at day 7. The PET study showed increased 18 F-FDG uptake in the intestine correlating to the severity of ulceration, returning to the basal level on day 7. Ex vivo imaging and g-counting showed that these regions of high uptake corresponded to regions of ulceration. A microautoradiographic study combined with immunohistochemistry revealed heavy accumulation of 18 F-FDG in inflammatory cells containing peroxidase on day 1 and in cells forming granulation tissue (a-smooth muscle actin-positive myofibroblasts and ED2-positive macrophages) on days 2-4 in and around ulcers. Proliferating (Ki67-immunopositive) intestinal crypt cells were also densely labeled with 18 F-FDG in intact intestinal tissue taken from the indomethacin-treated and the control animals. Conclusion: Our experimental data suggest that 18 F-FDG PET may be useful for evaluating the occurrence of small-intestine ulcers. Ulceration could be visualized early by the prominent uptake of 18 F-FDG by inflammatory cells and by the formation of granulation tissue by cells in and around ulcers.

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“…A small prospective study on only 27 patients having a suspected diagnosis of Crohn's disease shown a sensitivity of 93% and specificity of 84% for CE, also demonstrating significant changes in their management and subsequent outcome. (Girelli CM et al, 2007) A recent study shown that CE is useful in patients displaying atypical clinical symptoms, especially when surgery was performed at some point. (Mehdizadeh S et al, 2008) However, not all studies published so far rate CE as the most effective method of investigating Crohn's disease.…”

Section: Diagnostic Yield Comparison With Other Investigations and mentioning

confidence: 99%

Videocapsule Endoscopy of the Small Bowel

Vere¹,

Streba²,

Rogoveanu³

et al. 2011

New Techniques in Gastrointestinal Endoscopy

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Clinical outcome of patients examined by capsule endoscopy for suspected small bowel Crohn's disease

Cited by 57 publications

References 27 publications

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

PET and Macro- and Microautoradiographic Studies Combined with Immunohistochemistry for Monitoring Rat Intestinal Ulceration and Healing Processes

Videocapsule Endoscopy of the Small Bowel

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Clinical outcome of patients examined by capsule endoscopy for suspected small bowel Crohn's disease

Cited by 57 publications

References 27 publications

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

PET and Macro- and Microautoradiographic Studies Combined with Immunohistochemistry for Monitoring Rat Intestinal Ulceration and Healing Processes

Videocapsule Endoscopy of the Small Bowel

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Product

Resources

About

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease