Clinical outcome of oropharyngeal carcinoma treated with platinum-based chemoradiotherapy

Neoadjuvant Chemotherapy with Fluorouracil plus Nedaplatin or Cisplatin for Locally Advanced Nasopharyngeal Carcinoma: a Retrospective Study

“…Compared with CDDP, NDP has a different molecular structure but similar anticancer potencies, which is associated with a lower incidence of severe digestive symptoms and renal toxicity. Furthermore, numerous studies have indicated that NDP has wildly used in many kinds of tumors for its efficacy and safety, such as esophageal cancer 15 , non-small cell lung cancer 16 , uterine cervix cancer 17 , and some head and neck squamous cell carcinoma 18 , 19 . To date, the research of NDP versus CDDP in locally advanced NPC is mainly on the short-term efficacy and toxicity, but lack of the long-term survival outcome 20 .…”

Concurrent chemoradiotherapy with nedaplatin plus paclitaxel or fluorouracil for locoregionally advanced nasopharyngeal carcinoma: Survival and toxicity

“…Nedaplatin, a second‐generation cisplatin analog, also known as diamine(hydroxyacetato[2‐]‐O,O′) platinum, has similar anticancer potencies but with significantly fewer side effects, especially less nephrotoxicity compared to cisplatin . Since its approval in 1995, nedaplatin has been used as a substitute of cisplatin to treat non‐small cell lung cancer, uterine cervix cancer, esophageal cancer, and some head and neck squamous cell carcinomas . The anticancer efficacy and safety of nedaplatin has been well studied.…”

“…12,13 Since its approval in 1995, nedaplatin has been used as a substitute of cisplatin to treat non-small cell lung cancer, uterine cervix cancer, esophageal cancer, and some head and neck squamous cell carcinomas. [14][15][16][17][18] The anticancer efficacy and safety of nedaplatin has been well studied. A recent phase II clinical trial conducted by Cao et al, 19 reported the short-term equivalence of nedaplatin to cisplatin for the treatment of locoregionally advanced NPC.…”

Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome

“…The aetiology of tongue base carcinoma is the same as the rest of the oropharyngeal/laryngeal regions, with chronic smoking and drinking being the major risk factors. Other factors include geographical distribution, family history, old age, human papilloma virus, severe fungal infections, and environmental factors (i.e., asbestos exposure and exposure to welding fumes and polycyclic aromatic hydrocarbons) 1, 2, 5, 6.…”

“…However, confirmation of disease is usually carried out by an examination under anesthesia and guided biopsies. This is usually followed by staging which is likely to involve magnetic resonance imaging (MRI) of the head and neck, ultrasonic examination of the neck, and computed tomography of the chest and upper abdomen 1, 2, 5, 6.…”