Clinical outcome of intrauterine infusion of platelet‐rich plasma in patients with recurrent implantation failure

Abstract

Purpose This study aimed to evaluate the effectiveness of intrauterine infusion of platelet‐rich plasma (PRP) before embryo transfer (ET) in recurrent implantation failure (RIF) cases. Methods The authors retrospectively analyzed 54 ET cycles involving frozen and thawed high‐quality blastocysts after intrauterine PRP infusion between September 2019 and November 2020. All patients had a history of at least two times of implantation failure on ET. A total of 54 patients were categorized into two groups: thin endometrium (39 patients) and unexplained implantation failure (15 patients). In the thin‐endometrium group, the endometrial thickness (EMT) was <8.0 mm at cycle days 12–14 in the prior ET cycle. Results Among the 54 ET cycles after PRP infusion, 31 (57.4%) were positive for human chorionic gonadotropin (hCG) and 27 (50%) achieved clinical pregnancy, which was significantly better than that in prior ET cycles without PRP infusion (27.2% and 9.6%, respectively). The EMT was not increased at ET date on the PRP cycle compared with that in the prior ET cycle in both patient groups. Moreover, EMT was not different between the hCG‐positive and hCG‐negative groups. Conclusion Although intrauterine PRP infusion had no superior effect on increasing the EMT than conventional therapeutic agents, it resulted in high pregnancy rates in patients experiencing RIF with or without thin endometrium.

Intrauterine Infusion of Leukocyte-Poor Platelet-Rich Plasma Is an Effective Therapeutic Protocol for Patients with Recurrent Implantation Failure: A Retrospective Cohort Study

“…According to the results of the blastocyst-stage embryos (BSE)/cleavage-stage embryos (CSEs) transfer, further analysis of the data revealed that statistical differences in the β-hCGpositive rate, CPR, and LBR were only found between the BSE, PRP, and BSE control groups, which is similar to observations in other studies [29,30], whereas the three variables were similar in the CSE, PRP, and CSE control groups. This is a different result from that obtained for women with a history of RIF, whereby the PRP treatment appeared to improve the FET outcomes, with an increase in CPR and LBR [22].…”

“…To our knowledge, research on the efficacy of PRP intrauterine infusion for patients with RIF is ongoing. Positive results have been reported in several studies [29][30][31]. However, a few studies did not show a significant improvement with the PRP treatment [18], which could be related to differences in PRP preparation and administration techniques.…”

A study on the preoperative risk factors for primary healing failure in the reconstruction of deep sternal wound infection with platelet‐rich plasma and negative pressure trauma therapy

“…In addition to its release of all the growth factors in PLTs, PRP can also induce the overexpression of endogenous growth factors. Moreover, the high‐density granules in PLTs contain a large quantity of cytokines, chemokines, and active proteins, which participate in the regulation of inflammatory response and are an important stage of tissue repair 37 . This study also confirms that the patient's PLT level before PRP collection is one of the independent risk factors affecting the primary healing results, and the non‐primary healing rate decreases by 0.8% for every unit of increase in PLT.…”

The value of platelet-rich plasma in women with previous implantation failure: a systematic review and meta-analysis

“…All the studies were single centers except Kusumi [ 35 ], which was conducted in 7 fertility clinics. Eleven studies were conducted in Iran, 3 in Russia [ 22 , 29 , 34 ], 3 in China [ 17 , 36 , 39 ], 2 in India [ 38 , 45 ], 2 in Japan [ 35 , 41 ], and 1 study was conducted in each of the following countries: Bahrain [ 28 ], Canada [ 40 ], Egypt [ 20 ], South Korea [ 37 ], Turkey [ 42 ], and UK [ 32 ]. In 12 studies, the participants had recurrent implantation failure, in 5 studies had implantation failure, and in 10 studies, had thin endometrium.…”