Clinical Outcome of Exclusively Radiographer-led Delivery of Postoperative Vaginal Vault Brachytherapy for Endometrial Cancer – The Addenbrooke's Experience

Buckley, Hannah; Bradshaw, Karen D.; Gregory, D.; Prewett, S.; Tan, Li Tee

doi:10.1016/j.clon.2019.06.018

Cited by 4 publications

(10 citation statements)

References 16 publications

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“…With the increase of aging populations, obesity, and other metabolic diseases, as well as the delay of marriage and the increasing number of infertile patients, the incidence of EC is increasing and shows a younger trend [1]. Early diagnosis and treatment can improve the prognosis of patients with EC and reduce their clinical mortality [2]. However, for some early asymptomatic people, the diagnosis is in the late stage of EC and the etiology of EC has not been fully clarified.…”

Section: Introductionmentioning

confidence: 99%

RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA

Wang

Zhong

et al. 2020

Med Sci Monit

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Departmental sources Background: RNA binding protein RNPC1 has a tumor-suppressive role in various tumors, nevertheless, the role of RNPC1 in human endometrial cancer (EC) are never been reported. Material/Methods: Western blot, quantitative polymerase chain reaction and sphere forming analysis were performed to evaluate the stem-like traits of cells and RNPC1-induced effects on EC cell stemness. RNA immunoprecipitation (RIP) was constructed to investigate the underlying mechanisms. Results: The spheres formed by EC cells, named EC spheres, exhibited a remarkably higher stemness than the parental cells, which is characterized as the increase of sphere forming ability, ALDH1 activity, stemness marker expression and migration ability. Notably, RNPC1 expression was decreased in poorly differentiated EC cells than that in EC cells with moderately differentiated. Additionally, RNPC1 expression was significantly decreased in EC spheres and RNPC1 overexpression attenuated the stemness of EC spheres. Moreover, RNPC1 overexpression decreased the migration ability of EC spheres. Mechanistic studies showed that RNPC1 overexpression activated the Hippo pathway through directly binding to MST1/2. Inhibition of MST1/2 rescued RNPC1-mediated effects on EC sphere stemness. Conclusions: Therefore, our results indicate a novel RNPC1/MST1/2 signaling responsible for EC cell stemness.

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Section: Introductionmentioning

confidence: 99%

RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA

Wang

Zhong

et al. 2020

Med Sci Monit

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“…12,44,45 A total of eight of the included studies were UK-based and outlined the steps to implementation of an APRT role in the UK. 21,23,24,32,35,36,42,43 These papers discussed the four step APRT framework established by the UK called the 'four domains of practice'. These four domains are set out by national guidance and comprise the following domains: Eleven of the studies reported on the establishment of an APRT role in Canada, 8,14,17,19,22,26,[29][30][31]33,35 many of them referring to the four-step model previously created in the UK.…”

Section: Resultsmentioning

confidence: 99%

“…The APRT scope of practice varied between countries and departments as it was based on service needs. The roles and responsibilities expected of the APRT were discussed in 29 of the included studies, 6,[8][9][10]16,19,[21][22][23][25][26][27][30][31][32][33][34][35][37][38][39][40][41][42][43]46 though some papers provided much greater detail than others. The two main approaches in defining the APRT scope of practice were either site specific or service based.…”

Section: Scope Of Practice Of the Aprtmentioning

confidence: 99%

“…6,9,13,16,18,19,22,34,43 Examples of individual tasks included monitoring and management of toxicities, contouring and target volume delineation, and breast seroma delineation. Three studies discussed roles specific to gynaecological cancers 9,32,34 which mainly involved brachytherapy applicator insertion. Just one study discussed an APRT role in bladder cancer, 21 with the sole responsibility being 'plan of the day' selection.…”

Section: Scope Of Practice Of the Aprtmentioning

confidence: 99%

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Established advanced practice roles in radiation therapy: A scoping review

Lawlor,

Leech

2024

J Med Imag Rad Onc

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Advanced practitioners are healthcare professionals that are highly skilled with a particular area of expertise. These roles have been successfully implemented in many healthcare settings, improving efficiency of the service, as well as enhancing the standard of care received by patients. Although advanced practice roles have been implemented in some radiation therapy departments, their implementation have yet to be facilitated in the majority of countries. The purpose of this review is to scope the literature available regarding established advanced practice roles in radiation therapy. The PRISMA strategy for the identification of relevant literature was adhered to. Two data bases, EMBASE and PubMed, were searched using combinations of the key words ‘Advanced’, ‘Practice’, ‘APRT’, ‘Radiation’, ‘Therapy’ and ‘Radiotherapy’. Exclusion criteria were applied, and citation lists were also screened for additional relevant sources, including grey literature sources. A total of 35 relevant sources were identified that discussed advanced practice radiation therapy roles in the United Kingdom, Singapore, Canada, Australia and the USA. Means of role establishment and scope of practice were defined, and a number of advantages and challenges for advanced practice radiation therapist roles were identified. There are many benefits of implementing advanced practice roles in radiation therapy departments. Though the implementation of these roles can be challenging, the existing evidence indicates that it would be beneficial for the patient, the radiation therapist and the department as a whole. A more systematic approach, including reporting of quantitative outcomes may assist in the more widespread implementation of these roles.

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“…There is evidence that TR/RTT practice is improved or maintained compared to the gold-standard, with two exceptions in this One of the omissions of the research was the clinical evidence regarding the impact on treatment outcomes, with only one study 58 reporting local control rates and treatment toxicity. This finding agrees with other authors 12,148 who identified a lack of robust data on patient outcomes.…”

Section: Evidence Related To the Impact Of Ap Rolesmentioning

confidence: 99%

Advanced practice roles of therapeutic radiographers/radiation therapists: A systematic literature review

et al. 2022

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Clinical Outcome of Exclusively Radiographer-led Delivery of Postoperative Vaginal Vault Brachytherapy for Endometrial Cancer – The Addenbrooke's Experience

Cited by 4 publications

References 16 publications

RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA

RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA

Established advanced practice roles in radiation therapy: A scoping review

Advanced practice roles of therapeutic radiographers/radiation therapists: A systematic literature review

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