Clinical outcome of concomitant chemoradiotherapy followed by adjuvant temozolomide (TMZ) therapy for high-grade gliomas (HGG) in Colombia (RedLANO registry).
“…The standard of care for newly diagnosed GBM patients aged ≤70 years has been established by the EORTC/NCIC 3 trial, and 72.8% of cases considered in the present study underwent this treatment protocol (Table 1). Our survival data are comparable with those obtained in the EORTC/NCIC trial and the more recent RTOG 0525 trial, 9 as well data obtained in retrospective registries in North America (United States and Canada) 10,11 and South America (Columbia), 12 and seem better than data from Austria 13 and Switzerland. 14 In particular, these results are comparable with those reported in the retrospective Surveillance, Epidemiology and End Results (SEER) program, 6 in which 65% of patients received the combined treatment according to EORTC/NCIC, followed by an OS of 15 months; 23% of patients who received no postsurgical treatment had an OS of 2 months.…”
The median OS following standard temozolomide treatment concurrent with and adjuvant to radiotherapy given to (72.8% of) patients aged ≤70 years is consistent with findings reported from randomized phase III trials. The volume and expertise of the treatment center should be further investigated as a prognostic factor.
“…The standard of care for newly diagnosed GBM patients aged ≤70 years has been established by the EORTC/NCIC 3 trial, and 72.8% of cases considered in the present study underwent this treatment protocol (Table 1). Our survival data are comparable with those obtained in the EORTC/NCIC trial and the more recent RTOG 0525 trial, 9 as well data obtained in retrospective registries in North America (United States and Canada) 10,11 and South America (Columbia), 12 and seem better than data from Austria 13 and Switzerland. 14 In particular, these results are comparable with those reported in the retrospective Surveillance, Epidemiology and End Results (SEER) program, 6 in which 65% of patients received the combined treatment according to EORTC/NCIC, followed by an OS of 15 months; 23% of patients who received no postsurgical treatment had an OS of 2 months.…”
The median OS following standard temozolomide treatment concurrent with and adjuvant to radiotherapy given to (72.8% of) patients aged ≤70 years is consistent with findings reported from randomized phase III trials. The volume and expertise of the treatment center should be further investigated as a prognostic factor.
“…Among these, 351 articles were excluded after title screening and the abstract of the 784 remaining papers was assessed. Finally, 461 publications were excluded following the eligibility criteria and thus, 323 articles that had interpretable data and fulfilled the eligibility criteria were used for data extraction…”
Section: Resultsmentioning
confidence: 99%
“…In addition to the oncology databases, there were registries identified in diseases including heart failure (RECODEC 290,291 and ROCI 308 registries), trauma, 180,183,184,208,309 infectious diseases (GREBO 90,311,312 healthcare workers occupational exposure registry 192 ), and glomerulonephritis (Nefrored 174,177,188 ), among others 37,146,185,187,192,220,238,255,264 …”
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Recientemente, el Grupo de Trabajo en Neurooncología RANO (Response assessment in neuro-oncology) introdujo los criterios para la evaluación de la respuesta de los tumores gliales y su implicación clínica. La creación de esta plataforma y de su primer informe representa un importante paso para precisar la evolución del tratamiento en pacientes con gliomas de alto grado, no solo en el escenario de los ensayos clínicos, sino también en la práctica rutinaria. La terapia antiangiogénica y otras nuevas modalidades de tratamiento han aumentado la incidencia de fenómenos imaginológicos como la pseudoprogresión y la pseudorrespuesta. Igualmente, los nuevos criterios de la RANO toman en cuenta parámetros clínicos como el uso de esteroides y la presencia de síntomas neurológicos. Es importante que los neurorradiólogos, oncólogos y neurooncólogos conozcan estos criterios y adquieran experiencia en su aplicación correcta. Por otra parte, es necesaria más investigación que permita incluir nuevas técnicas de imagen, como la perfusión, difusión y espectroscopia, en el futuro próximo.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.