Clinical Outcome of Adjuvant Treatment of Endometrial Cancer Using Aperture-Based Intensity-Modulated Radiotherapy

Bouchard, M.; Nadeau, Sylvain; Gingras, L.; Raymond, Paul-Émile; Beaulieu, F.; Beaulieu, Luc; Fortin, A.; Germain, Isabelle

doi:10.1016/j.ijrobp.2007.12.004

Cited by 21 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are similar to the preliminary results that are available in the literature. 17,[29][30][31]33,34 The in-field vaginalnodal recurrence rate (11.8%) observed here did not differ from those of historical series [3][4][5][6] or those of recent IMRT publications; 17,31,[33][34][35] ; only Shih et al 29 showed a lower rate on in-field vaginal recurrence. Eleven patients (14.4%) developed only metastatic disease at the 29-month follow-up.…”

Section: Discussioncontrasting

confidence: 45%

See 1 more Smart Citation

Safety of adjuvant intensity-modulated postoperative radiation therapy in endometrial cancer: Clinical data and dosimetric parameters according to the International Commission on Radiation Units (ICRU) 83 report

Cordoba¹,

Nickers²,

Tresch³

et al. 2015

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 45%

“…Similarly, Beriwal et al 31 reported 3-year OSs and DFSs of 90% and 84%, respectively, in 47 patients. Bouchard et al 33 reported a 27-month DFS of 100% among 15 patients. Chen-Hsi Hsieh et al 34 observed 3-year DFS and OS rates of 94% and 88%, respectively, and a 6.5% rate of local failure in 31 patients.…”

Section: Discussionmentioning

confidence: 99%

Safety of adjuvant intensity-modulated postoperative radiation therapy in endometrial cancer: Clinical data and dosimetric parameters according to the International Commission on Radiation Units (ICRU) 83 report

Cordoba¹,

Nickers²,

Tresch³

et al. 2015

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

show abstract

“…Beriwal et al14 reported encouraging results for 3-year overall survival and disease-free survival in women with endometrial cancer treated postoperatively by IMRT, with rates of 90% and 84%, respectively. Bouchard et al15 also reported encouraging results for postoperative aperture-based IMRT in patients with endometrial cancer (Table 3). In the current study, the 3-year overall survival and locoregional control rates were 94% and 88%, respectively.…”

Section: Discussionmentioning

confidence: 89%

Helical tomotherapy provides efficacy similar to that of intensity-modulated radiation therapy with dosimetric benefits for endometrial carcinoma

Hsieh¹,

Shueng²,

Hsiao³

et al. 2012

OTT

View full text Add to dashboard Cite

BackgroundThe purpose of this study was to compare the efficacy of intensity-modulated radiotherapy (IMRT) and helical tomotherapy for endometrial cancer.MethodsBetween November 1, 2006 and November 31, 2010, 31 patients with histologically confirmed endometrial cancer were enrolled. All enrolled patients received total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant whole pelvic IMRT or helical tomotherapy.ResultsThe actuarial 3-year overall survival, disease-free survival, locoregional control, and distant metastasis-free rates for the IMRT and helical tomotherapy groups were 87.5% versus 100%, 91.7% versus 51.7%, 91.7% versus 83.3%, and 91.7% versus 51.7%, respectively. The conformal index and uniformity index for IMRT versus helical tomotherapy was 1.25 versus 1.17 (P = 0.04) and 1.08 versus 1.05 (P < 0.01), respectively. Two of 31 patients with cervical stump failure were noted, one in the IMRT group and the other in the helical tomotherapy group. No acute or late grade 3 or 4 toxicities were noted, including proctitis, or genitourinary or gastrointestinal disturbances.ConclusionHelical tomotherapy is as effective as IMRT and has better uniformity and conformal indices, and critical organ-sparing properties. Prospective clinical trials are needed to evaluate the comparative efficacy of IMRT versus helical tomotherapy.

show abstract

“…In the prone position, decreased dose to the small bowel was achieved by using bowel displacement devices [18-23]. The use of IMRT in clinical routine might decrease the risk for acute and late toxicity in patients after pelvic or paraaortic irradiation with comparable outcome [28,29,33,34,44-47]. Although IMRT and treatment in prone position on a belly board holds potential for decreased therapy related gastrointestinal toxicity, the implication of the patient's position when using IMRT has not been systematically investigated.…”

Section: Discussionmentioning

confidence: 99%

Intensity-Modulated Radiotherapy in Patients with Cervical Cancer. An intra-individual Comparison of Prone and Supine Positioning

et al. 2010

View full text Add to dashboard Cite

BackgroundChemoradiation for cervical cancer patients is associated with considerable gastrointestinal toxicity. Intensity-modulated radiotherapy (IMRT) has demonstrated superiority in terms of target coverage and normal tissue sparing in comparison to conventional 3D planning in gynaecological malignancies. Whether IMRT in prone (PP) or supine position (SP) might be beneficial for cervical cancer patients remains partially unanswered.Methods10 patients on FIGO stage IB-III cervical cancer, 6 patients for definitive and 4 patients for adjuvant external beam pelvic RT, were planned in PP and SP using a 7-field IMRT technique. IMRT plans for PP and SP (mean dose, Dmean 50.4 Gy) were optimized in terms of PTV coverage (1st priority) and small bowel sparing (2nd priority). A comparison of DVH parameters for PTV, small bowel, bladder, and rectum was performed.ResultsThe comparison showed a similar PTV coverage of 95% of the prescribed dose and for target conformity in IMRT plans (PP, SP). PTV, rectum and bladder volumes were comparable for PP and SP. Significantly larger volumes of small bowel were found in PP (436 cc, + 35%, p = 0.01). PP decreased the volume of small bowel at 20-50.4 Gy (p < 0.05) and increased the rectum volumes covered by doses from 10-40 Gy (p < 0.01), the V50.4 was < 5% in both treatment positions. Bladder sparing was significant better at 50.4 Gy (p = 0.03) for PP.ConclusionIn this dosimetric study, we demonstrated that pelvic IMRT in prone position for patients with cervical cancer seems to be beneficial in reducing small bowel volume at doses ≥20 Gy while providing similar target coverage and target conformity. The use of frequent image guidance with KV (kilovolt) or MV (megavolt) computertomography can reduce set-up deviations, and treatment in prone position can be done with a higher set-up accuracy. Clinical outcome studies are needed to affirm lower toxicity.

show abstract

Clinical Outcome of Adjuvant Treatment of Endometrial Cancer Using Aperture-Based Intensity-Modulated Radiotherapy

Cited by 21 publications

References 34 publications

Safety of adjuvant intensity-modulated postoperative radiation therapy in endometrial cancer: Clinical data and dosimetric parameters according to the International Commission on Radiation Units (ICRU) 83 report

Safety of adjuvant intensity-modulated postoperative radiation therapy in endometrial cancer: Clinical data and dosimetric parameters according to the International Commission on Radiation Units (ICRU) 83 report

Helical tomotherapy provides efficacy similar to that of intensity-modulated radiation therapy with dosimetric benefits for endometrial carcinoma

Intensity-Modulated Radiotherapy in Patients with Cervical Cancer. An intra-individual Comparison of Prone and Supine Positioning

Contact Info

Product

Resources

About