Clinical Outcome in Prostate Cancer Patients Undergoing High-Dose-Rate Brachytherapy With External Beam Radiotherapy in Our Institute

Sakamoto, Naotaka; Akitake, Masakazu; Ikoma, Saya; Ri, Ken; Masuda, Katsuaki; Yoshikawa, Masahide; Iguchi, Atsushi; Atsumi, Kazuhiko; Matsumura, Taisei; Uehara, Shuichiro

doi:10.5980/jpnjurol.102.621

Cited by 1 publication

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“…In contrary to permanent LDR implants, HDR BRT after loading catheters can be implanted accordingly, in order to cover areas of extracapsular or the seminal vesicles' infiltration or even the bladder pouch, extending its indication to coverage of even T4 tumors, as part of individualized curative treatment concepts. 14 , 66 , 67 Previous pelvic EBRT, prior pelvic surgery, and inflammatory bowel disease are not considered absolute contraindications for HDR prostate BRT but always a very thorough evaluation of the potential risks and benefits should take place, based on anatomy‐based dosimetry including carefully defined OARs dose constraints. 25 …”

Section: Introductionmentioning

confidence: 99%

High‐dose‐rate brachytherapy for prostate cancer: Rationale, current applications, and clinical outcome

et al. 2021

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Background: High-dose-rate brachytherapy (HDR BRT) has been enjoying rapid acceptance as a treatment modality offered to selected prostate cancer patients devoid of risk group, employed either in monotherapy setting or combined with external beam radiation therapy (EBRT) and is currently one of the most active clinical research areas.Recent findings: This review encompasses all the current evidence to support the use of HDR BRT in various clinical scenario and shines light to the HDR BRT rationale, as an ultimately conformal dose delivery method enabling safe dose escalation to the prostate. Conclusion:Valid long-term data, both in regard to the oncologic outcomes and toxicity profile, support the current clinical indication spectrum of HDR BRT. At the same time, this serves as solid, rigid ground for emerging therapeutic applications, allowing the technique to remain in the spotlight alongside stereotactic radiosurgery.

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