Clinical outcome in patients with venous thromboembolism and hidden cancer: findings from the RIETE Registry

Trujillo‐Santos, Javier; Prandoni, Paolo; Rivron-Guillot, Karine; Román, P.; Sánchez, Rosario; Tiberio, G; Monreal, Manuel

doi:10.1111/j.1538-7836.2008.02837.x

Cited by 62 publications

(34 citation statements)

References 22 publications

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“…Except for rising age, which is a predictor for cancer diagnosis both after a first and recurrent VTE, we found anaemia to be a risk factor for a new cancer diagnosis after a first primary VTE in accordance to results by Trujillo-Santo et al [15]. Anaemia has also been shown to increase the risk of VTE after cancer diagnosis [16] further supporting this connection.…”

Section: Discussionsupporting

confidence: 91%

“…This has not previously been shown. Ihaddadene et al [17] found no association between sex and occult malignancy, Sørenssen et al [10] found no particular gender difference and Trujillo-Santos et al [15] found an odds ratio of 1.3 for male sex but did not reach significance. The explanation for the increased risk of a cancer diagnosis associated with male sex found here is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

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Venous thromboembolism and cancer risk

Sandén

Svensson²,

Själander

2016

J Thromb Thrombolysis

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Cancer increases the risk of venous thromboembolism (VTE) and about 20 % of all VTE are associated with cancer. VTE can also be used as a marker for occult cancer. The objective was to examine the correlation between VTE and cancer regarding predictors for a subsequent cancer diagnosis. Patients treated for VTE between January 1st 2006 and December 31th 2011 were extracted from the Swedish national quality register AuriculA and crossmatched with the Swedish National Patient Register. In total 7854 patients corresponding to 14284 treatments years were examined. Primary VTE was found in 6451 patients, with 3936 first and 2515 recurrent VTE. There were 1403 patients with secondary VTE. After a first or recurrent primary VTE the incidence of cancer diagnose was high being 9.4–10.0 % the first year compared to 2.7–2.5 % during the second year. Cancer in the digestive organs was the most common type of cancer among those with first primary VTE with 19.2 % of diagnoses. In multivariable analysis age was found to increase the risk of cancer diagnosis after both first and recurrent primary VTE HR 1.02 (CI 1.02–1.03) and HR 1.02 (CI 1.01–1.03). For a first primary VTE anemia HR 2.13 (CI 1.48–3.08) and male sex HR 1.38 (CI 1.09–1.76) increased the risk while hypertension HR 0.74 (0.57–0.96), dementia HR 0.30 (CI 0.10–0.95) and history of major bleeding HR 0.52 (CI 0.28–0.97) reduced the risk of a subsequent cancer diagnosis. There is a substantial proportion of patients being diagnosed with cancer the first year after a primary VTE, anaemia and male sex confers an increased risk.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Venous thromboembolism and cancer risk

Sandén

Svensson²,

Själander

2016

J Thromb Thrombolysis

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“…41,42 With respect to cancer, in adult patients who presented with VTE, malignancy was diagnosed in 1.2% to 4%. [43][44][45] This rate is not clearly reported in children, but most likely should be lower than in adults. This suggests other risks factors, such as mechanical obstruction, chemotherapy, and CVL, are significantly involved in the development of VTE in this population.…”

Section: Resultsmentioning

confidence: 72%

Pediatric venous thromboembolism in relation to adults

Spentzouris

Scriven

Lee

et al. 2012

Journal of Vascular Surgery

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“…The spectrum of thrombotic episodes vary in severity, and these can present during or even prior to the diagnosis of cancer [2,3]. In a study of 17,475 patients with acute venous thromboembolism, 16% had a history of cancer, while hidden cancers were detected in 1.2% of patients [4].…”

Section: Introductionmentioning

confidence: 99%