Clinical outcome in children with Henoch-Schönlein nephritis

Mır, Sevgı; Yavaşcan, Önder; Mutlubaş, Fatma; Sozeri, Betul; Sönmez, Ferah

doi:10.1007/s00467-006-0278-0

Cited by 83 publications

(89 citation statements)

References 22 publications

(34 reference statements)

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“…[14][15][16] Children in >6 years age group had more chance of developing renal involvement similar to study by Nickavar et al and Trnka et al 17,18 According to Nickaver the mean age at presentation of nephritis was 87.4±30.9 months, which was significantly higher than the age of those without nephritis. 17 Age at presentation was the only predictor of renal involvement in their series.…”

supporting

confidence: 81%

Clinical profile and outcome of Henoch Schonlein purpura in a tertiary care hospital in South India

Abbas

Geetha

Deepthi

et al. 2017

Int J Contemp Pediatr

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Background: Henoch Schonlein purpura (HSP) is the most common systemic vasculitis in children. It is an immunoglobulin A (IgA) mediated systemic small-vessel vasculitis, with IgA deposition in vessel walls leading to symptoms involving the skin, joints, intestines, and kidneys. The objective of present study was to identify and describe the clinical profile, pattern of joint involvement, histopathological features, treatment modalities and complications of Henoch Schonlein purpura.Methods: 52 children less than 12 years diagnosed to have Henoch Schonlein Purpura according to the European League against Rheumatism criteria were included in the study. All patients were subjected to detailed history taking and thorough examination. The clinical features, investigations, management and complications of the disease were studied. Descriptive statistics was used to analyse the results.Results: The common clinical features were palpable purpura (100%) followed by arthritis (66%) and abdominal pain (50%). Renal manifestations were in the form of hematuria in 12% of the patients. Skin biopsy was done in 25 patients of which 19 had findings suggestive of Henoch Schonlein purpura. Steroids were used in 42% of patients. The severity of illness was associated with lower mean age, arthritis, leg edema and stool occult blood.Conclusions: The clinical features of Henoch Schonlein purpura in the population were different from the previously published studies. Renal involvement was less common. The short-term outcome of the patients were satisfactory.

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supporting

confidence: 81%

Clinical profile and outcome of Henoch Schonlein purpura in a tertiary care hospital in South India

Abbas

Geetha

Deepthi

et al. 2017

Int J Contemp Pediatr

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“…In future, a more detailed set of activity and chronicity markers may be able to increase the predictive value of renal biopsies in HSPN. Howevever, as renal biopsies suffer from sampling bias and only reflect the pathological process at the time of the biopsy, the prognostic significance of renal histology at the level of the individual patient is limited and is regarded by some authors as being less important than the clinical severity of HSPN [10,25].…”

Section: Renal Biopsy Findingsmentioning

confidence: 99%

Henoch–Schönlein purpura nephritis

Pöhl

2014

Pediatr Nephrol

124

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Henoch-Schönlein purpura (HSP) is the one of most common types of systemic vasculitis in childhood. Glomerulonephritis (HSPN) occurs in 30-50 % of HSP patients, mostly in a mild form but a small percentage of patients present with nephrotic syndrome or renal failure. HSPN is caused by the glomerular deposition of immunoglobulin A1 (IgA1)-containing immune complexes in the mesangium, the subepithelial and the subendothelial space. Formation of the IgA1 immune complex is thought to be the consequence of aberrantly glycosylated IgA1 molecules secreted into the circulation and their subsequent recognition by IgG specific for galactose-deficient IgA1. Mesangial proliferation and renal damage are triggered by the deposited immune complexes, which likely require activation of the complement system. Whereas other organ manifestations of HSP are mostly benign and self-limiting, HSPN might lead to chronic renal disease and end stage renal failure, thereby justifying immunosuppressive treatment. Long-term renal outcome correlates to the severity of the initial clinical presentation and the extent of renal biopsy changes, both of which are used to decide upon a possible treatment. As there are no evidence-based treatment options for severe HSPN, a large variety of therapeutic regimens are used. Prospective randomized controlled treatment studies are needed, but the low incidence of severe HSPN renders such studies difficult.

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“…Mevcut muayene bulguları ve öyküsü ile HSP tanısı alan hasta tek doz benzatin penisilin (600.000 İU, İM) uygulaması sonrası kliniğimize yatırılarak, takibe alındı. Klinik izlemin on üçüncü gününde herhangi GİRİŞ Henoch-Schönlein Purpurası (HSP) etiyolojisi tam olarak bilinmeyen ve başta cilt olmak üzere gastrointestinal sistem, eklemler, böbrekler ve daha seyrek olarak diğer organların etkilendiği çocukluk çağının en sık görülen vaskülitidir (1)(2)(3)(4)(5)(6)(7)(8). İnsidansı çeşitli ülkelerde değişmekle beraber 10-22/100000 olup, en sık 4 ile 6 yaş arası çocuklarda görülmektedir (9).…”

Section: Olguunclassified

Penile Involvement and Henoch-Schönlein Purpura: A Case Report

Yavaşcan¹,

Çelik²,

Anıl³

et al. 2012

Turk Neph Dial Transpl

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ÖzHenoch-Schönlein purpurası (HSP), artrit/artralji, gastrointestinal ve genitoüriner sistem tutulumunun eşlik ettiği non-trombositopenik purpura ile karakterize, çocukluk çağının en sık görülen vaskülitidir. Genitoüriner sistem tutulumu olan olgularda penis etkilenmesi oldukça nadirdir. Bu yazıda, HSP tanısı alarak, kısa süreli iyileşme sonrasında penis tutulumu ve artrit bulgularıyla tekrar başvuran dört buçuk yaşındaki bir erkek hasta sunulmak istenmiştir. Prednizolon (ağızdan, 1mg/kg/gün) tedavisi yanında lokal koruma tedavisi ile beş günde tamamen iyileşme sağlanmıştır. Sonuç olarak, penis tutulumu gösteren HSP olgularında, tartışmalı olmakla birlikte, steroid tedavisi uygulanabilir.anaHtaR sÖzcÜKLeR: Henoch-Schönlein purpurası, Penis tutulumu, Çocukluk çağı abstRact Henoch-Schönlein purpura (HSP), characterized by non-thrombocytopenic purpura accompanied by arthritis/arthralgia, gastrointestinal and genitourinary system involvement is the most common vasculitis in childhood. Associated penile involvement is very rare in patients with genitourinary system involvement. We report a 4.5 year-old boy with penile involvement and arthritis after a shortduration remission of HSP. Prednisolone (1mg/kg/day, orally) and conservative measures resulted in complete recovery within five days. In conclusion, steroid treatment could be administered in HSP children with penile involvement although controversial.

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Clinical outcome in children with Henoch-Schönlein nephritis

Cited by 83 publications

References 22 publications

Clinical profile and outcome of Henoch Schonlein purpura in a tertiary care hospital in South India

Clinical profile and outcome of Henoch Schonlein purpura in a tertiary care hospital in South India

Henoch–Schönlein purpura nephritis

Penile Involvement and Henoch-Schönlein Purpura: A Case Report

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