Clinical outcome and hemodynamic behavior of the Labcor Dokimos Plus aortic valve

Abstract

BackgroundThe Labcor Dokimos Plus (LDP) is a stented externally mounted pericardial aortic bioprosthesis, which was recently introduced in Europe. Aims of the study are evaluation of operative and postoperative results as well as hemodynamic performance.MethodsOne hundred consecutive patients with a mean age of 65.9 ± 10.7 years (range 35–87) and a mean EuroSCORE II of 3.1 ± 3.9 (range 0.67–24.5) underwent aortic valve replacement with the LDP. Mean valve-size was 25.2 ± 1.7 mm. Concomitant procedures were performed in 34% of the cases. Postoperative clinical data were analyzed and hemodynamic performance of the prostheses was evaluated by transthoracic echocardiography. Clinical follow-up was 100%, echocardiographic follow-up was 93% complete.ResultsIntraoperatively no peculiarities occurred. Mean cross clamp times for isolated and complex procedures were 74.5 ± 20.0 min and 103.7 ± 37.1 min, respectively. Patients were extubated after a mean of 9.4 ± 15.8 h. There were no perioperative strokes. Bleeding events occurred in 4 patients. 30-day-mortality was 2%. One case of early endocarditis occurred. Echocardiography showed maximum and mean pressure gradients of 18.1 ± 6.4 and 9.6 ± 3.7 mmHg, respectively. Correspondingly to valve sizes 21, 23, 25 and 27 mm, mean pressure gradients were 17.3, 9.5, 8.5 and 10.2 mmHg, effective orifice areas were 1.92, 1.79, 2.0, 2.16 cm2 and indexed effective orifice areas were 1.08, 0.95, 0.99 and 1.01 cm2/m2, respectively. No relevant regurgitations occurred.ConclusionsThe LDP showed operatively no peculiarities and a satisfactory clinical outcome with low perioperative morbidity and mortality. The hemodynamic performance of the implanted valve sizes was satisfactory.

Structural valve deterioration of the Labcor Dokimos aortic prosthesis: a single-centre experience

“…Out of 137 patients, 4 had moderate to severe paravalvular leakage that required reintervention. Another study that included 100 patients showed similar results in which no relevant central or paravalvular regurgitation was evident, and no structural or non-structural valve dysfunctions and no valve thrombosis were observed before discharge [ 10 ].…”

“…Prior studies assessed the performance of the Labcor Dokimos aortic valve postoperatively without short- or long-term follow-up [ 9 , 10 ]. In a single-centre study assessing the performance of the bioprosthesis, the haemodynamic results were satisfactory, i.e.…”

Conventional vs. Sutureless Aortic Valve Bioprosthesis: Is Faster Better?

“…This minimizes leaflet and commissural stress, improving its effective orifice area (EOA) and leaflet movement, while reducing the risk of leaflet abrasion, stent deformation, and calcification. It allows for both intraanular and supraannular implantation and has achieved satisfactory performance and clinical outcomes comparable to other stented pericardial substitutes [20].…”

Hemodynamics of Pericardial Aortic Valves: Contemporary Stented versus Stentless Valves in a Matched Comparison

“…Previously, the stented bioprosthesis LDP showed excellent hemodynamic results, which are comparable to other contemporary stented pericardial valves like the Edwards Perimount Magna (Edwards Lifesciences, Irvine, CA, USA) and the St. Jude Trifecta (Medtronic Inc., Minneapolis, MN, USA). [4][5][6] Similarly, the stentless SFS showed …”

“…2,3) However, conventional stented bioprostheses have been constantly improved and the latest generation of these valves also impressed with their hemodynamic profile. [4][5][6] The Labcor Dokimos Plus (LDP) valve is one of these stented pericardial bioprosthesis with a low profile stent and externally mounted leaflets for the supraannular position. 7) Table 1 shows the geometric dimensions of both prostheses.…”