Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx

Surgical management and oncological outcome of non-squamous cell carcinoma of the larynx: a bicentric study

“…In agreement with other authors [9,10], we applied the staging system for conventional laryngeal SCC since a histology-driven staging system is lacking. Moreover, this classification is the standard format for stratifying patients with laryngeal malignancies and is designed to establish treatment and prognosis.…”

“…According to the recent literature, the majority of publications are case reports or small case series [3,4,[11][12][13][14][15][16][17], including both malignant and benign neoplasms [12] and even non-neoplastic lesions [3]. Nevertheless, cohort studies and cross-sectional population analysis [9,18] considered only OS as survival end point. The population-based studies from National cancer Database are based on data that are over a decade old and lack detailed information on the pathological features and treatment modalities.…”

“…To the best of our knowledge, our study is the first to compare several oncological outcomes (OS, DSS, and DFS) and a functional one, such as the TLFS, between SCC and non-SCC. Unlike past studies [3,9,10,12,13], we did not include laryngeal lymphoma or metastatic location to the Fig. 3 A Forest plot of multivariable disease-specific survival analysis (DSS); survival curves derived from the multivariable DSS model showing the marginal effect of the stage (B) and of the histological type (C), adjusted for the effects of other covariates.…”

“…The population-based studies from National cancer Database are based on data that are over a decade old and lack detailed information on the pathological features and treatment modalities. Furthermore, only two studies compared non-SCC outcomes with SCC [ 9 , 10 ]. To the best of our knowledge, our study is the first to compare several oncological outcomes (OS, DSS, and DFS) and a functional one, such as the TLFS, between SCC and non-SCC.…”

Caracterização imunoistoquímica das diferenciações neuroendócrina e escamosa em carcinomas espinocelulares da região de cabeça e pescoço

“…glândula submandibular (Ferlito, Strojan et al 2014). Ainda na localização da laringe, o CNE é responsável por menos de 1% do total das neoplasias que surgem nesta área (Chen, Deng et al 2020). Acredita-se que essas neoplasias sejam oriundas de uma única célula-tronco tumoral, e sob os estímulos favoráveis do microambiente tumoral podem ter o potencial de desenvolver adquirindo o fenótipo neuroendócrino.…”