Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation

Ramirez‐Zamora, Adolfo; Kaszuba, Brian C.; Gee, Lucy; Prusik, Julia; Danisi, Fabio; Shin, Damian S.; Pilitsis, Julie G.

doi:10.7916/d8s182jj

Cited by 4 publications

(2 citation statements)

References 36 publications

(46 reference statements)

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“…To date, several reports highlighted the ventral intermediate nucleus of the thalamus (VIM) as the preferred target for Deep brain stimulation [ Table 1 ]. [ 9 ] Globus Pallidus internus (GPi) DBS should be considered in cases where VIM nucleus anatomy is grossly disrupted by intracranial pathology or when intraoperative tremor control is unsatisfactory despite VIM high-intensity stimulation. GPi DBS showed greater control of the resting tremor component and overall tremor reduction.…”

Section: Discussionmentioning

confidence: 99%

“…Among them dual thalamic stimulation VIM with Voa/Vop or with PSA showed significant improvement as it was proposed to override hypothesized dysfunction in both Cerebello-thalamic and Pallido-thalamic circuits. [ 9 10 ] HT usually requires higher voltage and frequency to control the tremors. Other programming options like double monopolar and interleaving stimulation are often utilized to control the tremors.…”

Section: Discussionmentioning

confidence: 99%

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Deep Brain Stimulation for Holmes Tremors and Literature Review

Lavanya,

Shankar,

Visvanathan

et al. 2023

Annals of Indian Academy of Neurology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Deep Brain Stimulation for Holmes Tremors and Literature Review

Lavanya,

Shankar,

Visvanathan

et al. 2023

Annals of Indian Academy of Neurology

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Deep Brain Stimulation for Cockayne Syndrome-Associated Movement Disorder

Domino¹,

Gelineau‐Morel²,

Kaufman³

2022

JMD

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Cockayne syndrome (CS) is a rare progeroid disorder characterized by multisystem degeneration, including neurological dysfunction, for which deep brain stimulation (DBS) is a proposed treatment. This study represents only the third case of DBS for CS-associated movement disorder and the first in which both proposed targets had devices implanted, allowing for direct comparison. A case of DBS for CS-associated movement disorder is presented. Previous literature documents two cases with one targeting the ventral intermediate nucleus of the thalamus (VIM) and the other targeting the globus pallidus interna (GPi). Our patient underwent stimulation of GPi nuclei followed by repositioning to VIM nuclei with improved symptom control using VIM stimulation. In all cases, there was a significant clinical benefit without off-target effects. CS-associated movement disorder exhibits phenotypic variability for which DBS is a viable treatment. Target selection should be driven by clinical phenotype.

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Deep brain stimulation in posterior subthalamic area for Holmes tremor: Case reports with review of the literature

et al. 2023

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BackgroundHolmes tremor (HT) is a refractory tremor associated with cortico-basal ganglia loops and cerebellothalamic tract abnormalities. Various drug treatments have been attempted; however, no treatment method has yet been established. Historically, thalamic deep brain stimulation (DBS) has been performed in medically refractory cases. Recently, the posterior subthalamic area (PSA) has been used for HT. Here, we report cases of HT and review the effectiveness and safety of PSA-DBS for HT.CasesWe conducted a retrospective chart review of two patients with HT who underwent PSA-DBS. Improvement in tremors was observed 1 year after surgery without apparent complications.Literature reviewWe identified 12 patients who underwent PSA-DBS for HT, including our cases. In six patients, PSA was targeted alone; for the rest, the ventralis intermediate nucleus (Vim) of the thalamus and PSA were simultaneously targeted. The Fahn–Tolosa–Marin Tremor Rating Scale improvement rates were 56.8% (range, 33.9–82.1%; n = 6) and 77.8% (range, 42.6–100%; n = 5) for the PSA-DBS and PSA+Vim-DBS, respectively.ConclusionReasonable improvements in HT were observed after PSA-DBS. PSA might be an appropriate target for improving the symptoms of HT. Long-term observations, accumulation of cases, and randomized studies are required in future.

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Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation

Cited by 4 publications

References 36 publications

Deep Brain Stimulation for Holmes Tremors and Literature Review

Deep Brain Stimulation for Holmes Tremors and Literature Review

Deep Brain Stimulation for Cockayne Syndrome-Associated Movement Disorder

Deep brain stimulation in posterior subthalamic area for Holmes tremor: Case reports with review of the literature

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