Clinical optical coherence tomography of early articular cartilage degeneration in patients with degenerative meniscal tears

Structural and functional changes of the articular surface in a post-traumatic model of early osteoarthritis measured by atomic force microscopy

“…In addition, a variety of techniques have been used to assess the structural degeneration of joint cartilage, including MRI (Burgkart et al, 2001;Burstein and Gray, 2003;Eckstein et al, 2006), micro-computed tomography-arthrography, (e.g., Piscaer et al, 2008), and optical coherence tomography (OCT) (Chu et al, 2010). With improvements in spatial resolution, these methods are becoming increasingly sensitive to changes in cartilage composition and structure, yet the relationship between these early changes and mechanical function in OA remains obscure.…”

Biological Augmentation and Tissue Engineering Approaches in Meniscus Surgery

“…The need to identify appropriate translational models in regenerative repair is therefore of critical importance and worthy of particular consideration here. Arnoczky et al, 72 Chu et al, 73 and Sah and Ratcliffe 74 have previously addressed this issue separately regarding articular cartilage, the meniscus, and regenerative medicine in general, and readers are referred to these texts for comprehensive coverage of this important issue. Ultimately, there are many animal models that are used in meniscus and articular cartilage defect research.…”

Novel Quantitative Imaging for Early Detection of Joint Tissue Injury to Support Early Treatment Strategies

“…1b). Correlation between OCT image features and MRI T2 values support the continued exploration of OCT as a clinical research tool [1,2,6].…”

“…MRI ultra-short TE-enhanced T2* (UTE-T2*) mapping reflects the cartilage collagen matrix integrity as determined by polarized light microscopy and is sensitive to signal from the deepest layers of cartilage adjacent to bone [2,3]. UTE-T2* mapping of articular cartilage and meniscus has the potential to visualize deep tissue characteristics better than standard T2 mapping due to its sensitivity to signal from short T2 tissues.…”