Clinical Observations on the Effect of Benzedrine Sulfate

Wilbur, Dwight L.; MacLean, Alexander R.; Allen, Edgar V.

doi:10.1001/jama.1937.02780340005003

Cited by 42 publications

(9 citation statements)

References 22 publications

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“…administration of adrenaline and noradrenaline even in high dosage did not produce sweating in the small areas of skin studied by local techniques by Chalmers & Keele (1951) and by Foster et al (1970). Earlier reports suggested that given systemically, ephedrine, benzedrine and neo-synephrine may induce sweating in man (Chen & Schmidt, 1930; Wilbur, Maclean & Allen, 1937;Haimovici, 1948), but only the third of these is based on objective measurements.…”

Section: Introductionmentioning

confidence: 99%

The role of circulating catecholamines in sweat production in man

Allen¹,

Roddie²

1972

The Journal of Physiology

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SUMMARY1. The effects of intravenous infusions of adrenaline, isoprenaline and noradrenaline on human sweating were assessed by continuous measurement of total body weight loss in normal subjects.2. All three catecholamines increased the rate of weight loss but isoprenaline was effective in a much smaller dosage than either adrenaline or noradrenaline.3. fl-adrenoceptor blockade with propranolol reduced the response.4. The response was not abolished by collecting expired air in a Douglas bag suggesting that it was not due to an increase in respiratory water loss.5. The response was not abolished by atropine infusions suggesting that it was not mediated through cholinergic sudomotor nerves.6. It is concluded that intravenous infusions of catecholamines may elicit a small, non-cholinergically mediated sweat response in man.

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Section: Introductionmentioning

confidence: 99%

The role of circulating catecholamines in sweat production in man

Allen¹,

Roddie²

1972

The Journal of Physiology

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“…They have also proved useful in medically ill depressed patients as well as in the more classic syndromes of attention deficit disorder, narcolepsy, and refractory depression (Chiarello, 1987). Chronic, pathological fatigue, and neurasthenia have also responded to this class of medication (Chiarello, 1987;Wilbur, 1937), without specific mention of fatigue associated with hypothyroidism. The mechanism action of psychostimulants, such as d-amphetamine, is to increase catecholamines by indirect release from storage granules in synaptic terminals, as well as inhibition of re-uptake (Chiarello, 1987).…”

Section: Discussionmentioning

confidence: 99%

Treatment of anergic depression in hashimoto's thyroiditis with fluoxetine and d‐amphetamine

Cohen

1993

Depression

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s thyroiditis has been known to produce symptoms of severe anergia, f a t i p e , and depression. The hypothyroidism impairs cerebralfinction causing marked motor slowing which complicates the treatment of concomitant depression. In this open trial, three patients with documented Hashimoto ' s thyroiditis and Major Depression responded to a combination of jluoxetine and d-amphetamine. Despite improvement in mood with jluoxetine alone, all three patients had persistent anergia which resolved after the addition of damphetamine to their regimen. A discussion of the unique aspects of anergia and depression associated with hypothyroidism follows, with a focus on the cerebral impairment and delayed reaction time that complicates this illness. The neurotransmitter enhancing properties of serotonin re-uptake inhibitors and direct-acting psychostimulantsmay, in combination, providea unique treatment approach to anergic depression associated with hypothyroidism. Depression 1:llO-114 (1993).0 1993 Wiley-Lks, Inc.

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“…Bromide or luminal may be of occasional value. Benzedrine on rising has been used with success to produce temporary improvement as an aid to psychotherapy (Myerson, 1936;Wilbur, MacLean, and Allen, 1937), and I have sometimes found it useful. Prognosis In considering the results of treatment recorded by different authors it is wise to compare only the percentage returned to full duty, for whether a soldier is put on light duty or whether he is discharged may depend upon the importance of his civil occupation.…”

Section: Discussionmentioning

confidence: 99%

Da Costa's Syndrome: Aetiology. Lecture III

Wood¹

1941

BMJ

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Clinical Observations on the Effect of Benzedrine Sulfate

Cited by 42 publications

References 22 publications

The role of circulating catecholamines in sweat production in man

The role of circulating catecholamines in sweat production in man

Treatment of anergic depression in hashimoto's thyroiditis with fluoxetine and d‐amphetamine

Da Costa's Syndrome: Aetiology. Lecture III

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