Clinical Observations of Acute Friedländer Pneumonia

Changing Bacteriology of Adult Community‐Acquired Lung Abscess in Taiwan:Klebsiella pneumoniaeversus Anaerobes

“…Diabetes mellitus (46%) was an important risk factor associated with K. pneumoniae lung abscess in this study, but prevalences of other reported predisposing factors for K. pneumoniae infection, such as alcoholism [14][15][16], did not differ between patients with a lung abscess due to K. pneumoniae and those with a lung abscess due to other pathogens. Approximately 50% of community-acquired K. pneumoniae infections (other than lung abscesses) in Taiwan were found to be associated with diabetes mellitus [19][20][21]27].…”

“…Lung abscesses due to K. pneumoniae were reported in small studies before the 1970s [14][15][16]. In recent study of lung abscess with diagnostic methods that were uncontaminated with bacteria from the upper airway, K. pneumoniae accounted for !5% of these infections [12,17,18].…”

Effect of Alcohol Consumption on Host Release of Interleukin‐17 During Pulmonary Infection With Klebsiella pneumoniae

“…The most frequent infectious complication of alcohol abuse is bacterial pneumonia (Winterbauer et al, 1969), and age-specific death rates due to this infection have been found to be 3-to 7-fold greater in alcoholics compared with the general population (Schmidt and de Lint, 1972;Sundby, 1967). Alcoholics contract pneumonia due to a variety of bacterial species, but the Gramnegative bacterium Klebsiella pneumoniae, studied here, has a particularly strong association with alcohol consumption (Adams and Jordan, 1984;Manfredi et al, 1963).…”

Inhibition of TNF-α processing and TACE-mediated ectodomain shedding by ethanol

“…Alcohol (EtOH) has long been recognized as an immunosuppressive drug and a risk factor for a spectrum of infectious diseases [1][2][3]. Among these infections, bacterial pneumonias are most closely correlated with alcohol abuse [4][5][6][7]. Alcoholics are more likely to be colonized with pathogenic strains of bacteria and are at increased risk for aspiration of these bacteria in oropharyngeal secretions.…”