Clinical Observation of the Correlation Between Overactive Bladder and Atopic Constitution in Children

Zheng, Yue; Zhang, Zhou; Hou, Ling; Wang, Xiuli; Jiang, Kailei; Zhang, Shucheng; Du, Ye

doi:10.3389/fped.2021.646118

Cited by 4 publications

(4 citation statements)

References 18 publications

(16 reference statements)

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“…There was a statistically significant increase (5.227 times) in the occurrence of OAB in asthmatic children. Zheng et al found that OAB in children was associated with atopic symptoms including eczema, skin irritation, allergic rhinitis, allergic cough, and elevated total serum IgE level [ 35 ]. Histamine activates phospholipase C via the G protein when it binds to the H1 receptor.…”

Section: Discussionmentioning

confidence: 99%

“…Histamine is released when mast cells are activated, resulting in inflammation and sensitivity of the bladder. Through H1 receptors, histamine can also raise the afferent nerve’s bladder sensitivity, resulting in excessive bladder contractions [ 35 – 37 ]. Given that atopic asthma is the most prevalent form of asthma in children, the aforementioned mechanisms can cause OAB in children with asthma.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the association between asthma and non-neurogenic urinary incontinence in children; a case-control study

et al. 2023

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Background Asthma is the most common chronic disease in children. Asthma can lead to sleep disorders and psychiatric issues, which are often accompanied by urinary incontinence in children. Furthermore, several studies have shown a relationship between allergic diseases and urinary incontinence. This study aims to examine the association between asthma and non-neurogenic urinary incontinence. Materials and methods This case-control study included 314 children over three years old referred to Amir Kabir Hospital; 157 with asthma and 157 without asthma. After explaining each urinary disorder in accordace with the International Children’s Continence Society’s definitions, parents and children were asked about their presence. The disorders included monosymptomatic nocturnal enuresis(MNE), nonmonosymptomatic nocturnal enuresis (NMNE), vaginal reflux (VR), pollakiuria, infrequent voiding, giggle incontinence (GI), and overactive bladder (OAB). The analysis was performed using Stata 16. Results The average age of the children was 8.19 ± 3.15 years. Patients with asthma (p = 0.0001) and GI (p = 0.027) had a considerably lower average age than patients without these disorders. Asthma and urinary incontinence, including NMNE, Infrequent voiding, and OAB, were significantly correlated (p = 0.017, 0.013, and 0.0001, respectively). Moreover, the association between MNE and asthma was significant in males (p = 0.047). Conclusion Due to the relationship between asthma and urinary incontinence, children with asthma must be evaluated for the presence of urinary disorders and, if present, receive the proper treatment in order to improve their quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of the association between asthma and non-neurogenic urinary incontinence in children; a case-control study

et al. 2023

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“…One of our previous studies revealed that children with OAB had other common allergic symptoms, and the effective rate of treatment for OAB by avoiding allergens combined with antihistamine treatment was 96.1%, suggesting that allergic factors are involved in the pathogenesis of OAB (5). Therefore, we expanded the sample size and retrospectively analyzed the risk factors for children with OAB, evaluated the effectiveness of antihistamines in the treatment of OAB and the risk factors for ineffective treatment in patients with allergies and urodynamics in children with OAB in order to improve the understanding of the pathogenesis of OAB in children and provide new treatment ideas for children with OAB complicated with allergies.…”

Section: Introductionmentioning

confidence: 95%

Clinical Correlation Between Overactive Bladder and Allergy in Children

et al. 2022

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Background:The International Children's Continence Society defines overactive bladder (OAB) as a clinical syndrome characterized by urgency of urination usually accompanied by frequent urination and nocturia symptoms. This study aims to explore the correlation between overactive bladder (OAB) and allergy in children.Method:The clinical characteristics of 918 patients diagnosed with OAB from January 2020 to March 2021 were retrospectively analyzed. Risk factors for OAB were analyzed using logistic regression analysis, and the effect of desloratadine in the treatment of OAB was evaluated.Results:The incidence of allergic cough or allergic rhinitis in the mild OAB group was higher than the moderate–severe group. Urodynamics demonstrated that the proportion of patients with a sensitive bladder in the overactive detrusor group was significantly higher than the non-overactive detrusor group. The effective rate of treatment of OAB in patients complicated with allergies and taking desloratadine was 90.14%, which was significantly higher than in patients who were not taking desloratadine, and blood IgE level was a risk factor of ineffective treatment with desloratadine.Conclusion:OAB is correlated with allergies in children, and desloratadine can effectively improve OAB symptoms.

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“…Other symptoms involve holding manoeuvres, feeling of incomplete emptying, postmicturition dribble, and genital and lower urinary tract pain [7]. Studies were concerned with the possible association between presence of voiding dysfunction and allergic disorders [3,8].…”

Section: Introductionmentioning

confidence: 99%

Urological Manifestations in Pediatric Patients with Allergic Disorders: Associations or Manifestations.

Hassan,

Elhakim,

Elsoudy

et al. 2023

GEGET

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Introduction:The association between urinary abnormalities and allergic diseases was studied, but coincidence of allergy flare-ups with urological manifestations was seldomly discussed. Aim of study: assess presence of urological manifestations in pediatric patients with various types of allergies and determine change in urological manifestations with allergic activity. Methods: cross sectional pilot study with nested follow up, conducted in Allergy, Immunology and Rheumatology Clinic, Children's Hospital, our university over 6 months, March 2022 to September 2022. Patients diagnosed as allergy recruited consecutively during routine follow up. All patients screened at time of allergy flare-up for urological symptoms, 50 patients associated with urological symptoms were investigated at time of enrolment and at remission. Investigations included urine analysis, urinary eosinophils, and urinary eosinophilic cationic protein. Results: Among 193 allergic children, 50 patients, aged 8.04 ± 2.97 years old, 28 (56%) boys and 22 (44%) girls, developed urological symptoms at time of allergy exacerbation (31.6%), 38% had combined forms of allergy. Statistically significant decline of urological manifestations found by time of allergy remission, on allergy controller therapies. Eosinophils were microscopically detectable in the urine of 18 (36%) of the studied patients during allergy flare-up, and not detected by remission. Urinary ECP median level was significantly higher at exacerbation than allergy convalescence. Conclusion: Urological manifestations commonly associated with allergy flare-up, regardless type of allergy. Presence of urinary eosinophils and elevated levels of urinary ECP at allergy flare ups suggest that urinary system could be targeted by allergens, which needs more elucidation in further studies.

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Clinical Observation of the Correlation Between Overactive Bladder and Atopic Constitution in Children

Cited by 4 publications

References 18 publications

Evaluation of the association between asthma and non-neurogenic urinary incontinence in children; a case-control study

Evaluation of the association between asthma and non-neurogenic urinary incontinence in children; a case-control study

Clinical Correlation Between Overactive Bladder and Allergy in Children

Urological Manifestations in Pediatric Patients with Allergic Disorders: Associations or Manifestations.

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