Clinical Observation of Retinal Vessel Density In Type 2 Diabetic Patients With High Mopyopia

Abstract

Purpose: To quantitatively analyze the difference of superficial and deep retinal vessel density between diabetic patients with high myopia , diabetic patients without high myopia and normal subjects.Methods: This cross-sectional study recruited type 2 diabetic patients with no history of ocular treatment in Shijiazhuang, China.Thirty type 2 diabetic patients with high myopia (30 eyes) were included in group A, 30 type 2 diabetic patients (30 eyes) without myopia were included in group B. Another 30 sex-,age-matched healthy volunteers (30 eyes)were included in group C. The superficial and deep retinal vessel density were measured and compared among the three groups to determine the effects of high myopia on diabetes.Results: No statistically significant differences in central superficial retinal vessel density(CSVD) was found in three groups（P＞0. 05).There were significant differences in the temporal superficial retinal vessel density（TSVD）,superior superficial retinal vessel density(SSVD), nasal superficial retinal vessel density(NSVD),inferior superficial retinal vessel density(ISVD) between the three groups, respectively (P＜0.05).TSVD,SSVD,NSVD,ISVD in group A were all lower than those in group B and group C(P ＜0.05).ISVD in group B was lower than that in group C and no statistically significant differences in TSVD,SSVD,NSVD were found between groups B and C(P＞0.05). There were significant differences in central deep retinal vessel density(CDVD),temporal deep retinal vessel density(TDVD),superior deep retinal vessel density(SDVD), nasal deep retinal vessel density(NDVD),inferior deep retinal vessel density(IDVD) between the three groups, respectively (P＜0.05).CDVD in group A was higher than that in group B , but there was no significant difference between group A and group C.TDVD,SDVD,NDVD,IDVD in group A were all lower than those in group B and C(P ＜0.05),and those in group B were lower than those in group C(P ＜0.05).Conclusion: Myopia and diabetes are important factors affecting vessel density. The parafoveal superficial and deep vessel density of type 2 diabetic patients with high myopia were lower than those of diabetics and normal persons. However,there was no difference in macular fovea superficial and deep retinal vessel density between diabetic patients with high myopia and normal persons.Myopia did not show a protective effect on retinal vessel density reduction in diabetic patients.

Clinical Observation of Macular Vessel Density in Type 2 Diabetics with High Myopia

“…This manuscript does not include any nonauthor contributions to acknowledge. This manuscript has been reported as a preprint [29].…”