Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial

Gai, Ming-ying; Wu, Longfei; Su, Qi-feng; Tatsumoto, Karin

doi:10.1016/s0301-2115(03)00287-2

Cited by 189 publications

(236 citation statements)

References 4 publications

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“…Other haematological and biochemical parameters did not have any significant difference in the two groups. These results were comparable with the study by Movafegh et al [6] and Gai et al [7].…”

Section: Discussionsupporting

confidence: 92%

“…A similar study was carried out by Ming-ying Gai et al [7] in China by administering tranexamic acid 10 min before skin incision. The intervention led to less bleeding 2 h post-operatively, 42.75 ± 40.45 ml in the study group versus 73.98 ± 77.09 ml in the control group (p = 0.001) but did not show any decrease in post-placental delivery blood loss.…”

Section: Discussionmentioning

confidence: 82%

“…Other parameters such as systolic blood pressure, diastolic blood pressure and respiratory rate did not have any significant difference in the two groups. In the study by Movafegh et al [6] and Gai et al [7], there was no significant increase in pulse as also the other post-operative vitals.…”

Section: Discussionmentioning

confidence: 85%

“…Tranexamic acid also inhibits conversion of plasminogen to plasmin [8]. After delivery of baby, there is transient activation of fibrinolytic cascade for 6-10 h [7]. So the efficacy of an anti-fibrinolytic agent such as tranexamic acid is being evaluated for the prevention of PPH.…”

Section: Discussionmentioning

confidence: 99%

“…Mean blood loss from mops and sheets was calculated using the formula used by Gai et al [7]: blood from mops and sheets = (weight of soaked material-weight of dry material)/1.05, where 1.05 is the specific gravity of blood at 37°C. To this, the blood drained in the suction container after delivery of placenta was added to get the total intraoperative blood loss.…”

Section: Methodsmentioning

confidence: 99%

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Role of Intravenous Tranexamic Acid on Caesarean Blood Loss: A Prospective Randomised Study

Ray

Bhattacharya

Chakraborty

et al. 2016

J Obstet Gynecol India

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Background Post-partum haemorrhage (PPH) is a major cause of maternal mortality globally. Tranexamic acid, an anti-fibrinolytic agent, is a novel approach in an attempt to prevent this dreadful complication. This study aims to document the efficacy of intravenous (IV) tranexamic acid in reducing blood loss during and after caesarean section (CS). Methods In this prospective randomised placebo-controlled open-label study, 100 mothers scheduled for elective CS were randomly selected and divided into two groups (study and control) of 50 each. The study group received 1 g IV tranexamic acid and the control group received IV placebo. Following delivery, all mothers received ten units of oxytocin in 500 ml of normal saline.Results The mean intra-operative and post-partum blood loss were significantly lower in the study group than the control group: 499.11 ± 111.2 and 59.93 ± 12.5 ml versus 690.85 ± 198.41 and 110.06 ± 13.47 ml, respectively, (p \ 0.001). Total blood loss was 30 % less in the study group (p \ 0.001). Six mothers had PPH in the control group, while none in the study group. The difference between the pre-operative and post-operative haemoglobin levels was significantly less in the study group than the control group, 0.26 ± 0.22 versus 0.99 ± 0.48 g% (p \ 0.001).There was no significant difference with respect to other haematological parameters. There was no added adverse effect or need for NICU admission in the study group. Conclusion Pre-operative IV tranexamic acid significantly reduced blood loss during elective CS without any significant adverse effects.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 82%