Background: Adherence to ethical standards is a vital component of nursing care and is influenced by various circumstances. Identifying such aspects can improve ethical performance. Objective: This study examined critical care nurses' compliance with ethical rules and their impact on spiritual well-being (SWB) and moral sensitivity (MS). Study Design: The research was primarily descriptive and correlational. Setting: The study was conducted at Bahria Town International Hospital Lahore. Duration of Study: This study was conducted from May 1, 2023, to December 10, 2023. Methods: Data were compiled on the individuals' demographics and three essential questionnaires: the adherence to ethical norms questionnaire, the moral sensitivity questionnaire (MSQ), and the spiritual well-being scale (SWBS). The study included 51 nurses, with the bulk of participants being female (76.4%), single (64.7%), without kids (72.54%), possessing a diploma in nursing (84.3%), and graduates of public universities (66.9%). Results: The mean score of adherence to ethical codes was 64.06±7.11, indicating a satisfactory level of commitment to ethical principles. The mean SWB score was 91.67±10.54, with 74.5% (n=38) falling into the moderate category. The mean scores for existential and religious health were 44.85±6.73 and 47.72±5.53, respectively. The mean MS score was 135.63±10.53, with most subjects falling into the moderate category. Multivariate regression analysis revealed a significant correlation between SWB, MS, and ethical code adherence among nurses (P<0.05).Conclusion: Critical care nurses demonstrated a solid commitment to ethical standards. MS and SWB also improved their commitment to ethical rules. Nursing managers may use these findings to promote MS and SWB among nurses, leading to better ethical performance.