Clinical Notes on the Possible Anticholinergic Reversal of Depressive Syndromes

Ungvari, Gabor S.; Karczag, I; Gerevich, József; Pethö, B

doi:10.1055/s-2007-1019569

Cited by 7 publications

(2 citation statements)

References 6 publications

(9 reference statements)

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“…Several studies have shown the antidepressant efficacy of acetylcholinergic drugs [ 153 , 154 , 155 , 156 ] or dosage-dependent antidepressant effects mostly of scopolamine [ 157 , 158 , 159 ]. While studies suggest that some selective serotonin reuptake inhibitors (SSRI) like fluorexine or citalopram can improve depression in PD patients, others report that fluorexine has a lot of side effects and worsened the tremor and motor symptoms in PD patients [ 52 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 ].…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Antipova

Holzmann

Hawlitschka

et al. 2021

Toxins

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Parkinson’s patients often suffer from depression and anxiety, for which there are no optimal treatments. Hemiparkinsonian (hemi-PD) rats were used to test whether intrastriatal Botulinum neurotoxin-A (BoNT-A) application could also have antidepressant-like properties in addition to the known improvement of motor performance. To quantify depression- and anxiety-like behavior, the forced swim test, tail suspension test, open field test, and elevated plus maze test were applied to hemi-PD rats injected with BoNT-A or vehicle. Furthermore, we correlated the results in the forced swim test, open field test, and elevated plus maze test with the rotational behavior induced by apomorphine and amphetamine. Hemi-PD rats did not show significant anxiety-like behavior as compared with Sham 6-OHDA- + Sham BoNT-A-injected as well as with non-injected rats. However, hemi-PD rats demonstrated increased depression-like behaviors compared with Sham- or non-injected rats; this was seen by increased struggling frequency and increased immobility frequency. Hemi-PD rats intrastriatally injected with BoNT-A exhibited reduced depression-like behavior compared with the respective vehicle-receiving hemi-PD animals. The significant effects of intrastriatally applied BoNT-A seen in the forced swim test are reminiscent of those found after various antidepressant drug therapies. Our data correspond with the efficacy of BoNT-A treatment of glabellar frown lines in treating patients with major depression and suggest that also intrastriatal injected BoNT-A may have some antidepressant-like effect on hemi-PD.

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Section: Introductionmentioning

confidence: 99%

Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Antipova

Holzmann

Hawlitschka

et al. 2021

Toxins

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“…Case reports describe depressed patients who developed pharmacological confusional syndromes in the course of combination therapy with neuroleptics and tricyclic antidepressants, and emerged from the confusional state recovered from depression (Ungvari et al, 1981). Gisselmann et al (1975) induced confusional states with orphenadrine in 10 depressed patients (4 melancholic, 2 with involutional melancholia, 2 chronically psychotic depressed, and 2 neurotic depressives).…”

Section: Depressionmentioning

confidence: 97%

Acetylcholine and affective disorder

Leong

Brown

1987

J. Neural Transmission

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We reviewed the evidence for involvement of central cholinergic neurons in affective disorder. Cholinomimetics inhibit speech, thought, and activity in most subjects, decrease manic symptoms and, in some affective disorder patients, produce depressive symptoms. Cholinomimetics also cause ACTH and cortisol secretion and decrease latency to REM sleep. It is unclear whether cholinomimetics are specifically "antimanic" or "depressogenic" or whether their fundamental effect is nonspecific behavioral inhibition; whether the observed effects of cholinomimetics are mediated largely through cholinergic pathways, are secondary to changes in other neurotransmitters or are part of a nonspecific stress response. The suggestion that anticholinergic agents have mood elevating properties has not yet been subjected to controlled investigation. Although the proposal that affective disorders involve cholinergic neurons has received some support from clinical investigation further research is required to substantiate the intriguing observations to date and to clarify the physiologic and psychologic processes mediating them.

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The cholinolytic biperiden in depression

Beckmann

Moises

1982

Arch Psychiatr Nervenkr

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Clinical and experimental work indicates that cholinergic functions might play a role in modulating affectivity in man. In this acute double-blind study either the cholinolytic agent biperiden or placebo infusions were administered to six depressed females. The Janke and Debus self-rating questionnaire (EWL-K), the modified Hamilton depression scale (HAM-D), and the Montgomery and Asberg depression scale (MADRS) were used for documentation of psychopathological change. There was an acute antidepressant effect during infusion of the active drug in comparison to placebo as measured on the global MADRS and EWL-K, but not on the modified HAM-D. Single items such as depressed mood, work and interests (HAM-D), sadness, concentration difficulties, inability to feel (MADR-S), and depressiveness (EWL-K) responded selectively and significantly to the biperiden infusion. It is concluded that cholinergic activity might be involved in the regulation of affectivity in man.

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Clinical Notes on the Possible Anticholinergic Reversal of Depressive Syndromes

Cited by 7 publications

References 6 publications

Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Acetylcholine and affective disorder

The cholinolytic biperiden in depression

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