Clinical Nodal Stage Is an Independently Significant Predictor of Distant Failure in Patients With Squamous Cell Carcinoma of the Larynx

Matsuo, Jeannette Marie S.; Patel, Snehal G.; Singh, Bhuvanesh; Wong, Richard J.; Boyle, Jay O.; Kraus, Dennis H.; Shaha, Ashok R.; Zeléfsky, Michael J.; Pfister, David G.; Shah, Jatin P.

doi:10.1097/01.sla.0000086660.35809.8a

Cited by 54 publications

(48 citation statements)

References 27 publications

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“…However, the results are worse for local and regional control of advanced tumors (T3 and T4), especially if there are large lymph node metastases. 6 Goepfert et al 7 showed that the results of radiotherapy are similar to those of surgery for supraglottic lesions that can be removed with partial laryngectomy; ranging from 88.5% for T1 lesions to 60% for T4 lesions. The M.D.…”

Section: Discussionmentioning

confidence: 99%

Avaliação da sobrevida livre de doença em pacientes com carcinoma epidermoide de laringe submetidos à tratamento radioterápico exclusivo ou associado à quimioterapia

Chedid¹,

Lehn²,

Rapoport³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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In early stage (I and II) laryngeal squamous cell carcinoma, both surgery and radiotherapy results in significant local and regional control. In advanced tumors (III and IV), radiotherapy alone has local-regional control rates of 32-43%. Aim: To assess disease-free survival in SCC laryngeal carcinoma patients submitted to radiotherapy alone and/or associated with chemotherapy. Materials and Methods: Retrospective study involving 84 cases of laryngeal SCC treated with radiotherapy or chemotherapy together with radiotherapy. Fifty-three cases were treated with intension to cure and 31 because of impossibility to resect the disease. As to clinical stage (CS), 12 were CS I, 15 II, 21 III and 5 IV. In the second group, 11 cases were EC III and 20 IV. Results: Mean age was 60 years, 84.5% were men. Fifty-eight (69.1%) cases had complete response and 26 (30.9%) had persistent or residual disease. Five-year disease-free survival was of 42.5%; 62.5% of the patients with organ preservation indication and 9.75 in the group of irressecable disease. Conclusion: disease-free survival of those patients submitted to radiotherapy because of laryngeal SCC was of 62.5%

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Section: Discussionmentioning

confidence: 99%

Avaliação da sobrevida livre de doença em pacientes com carcinoma epidermoide de laringe submetidos à tratamento radioterápico exclusivo ou associado à quimioterapia

Chedid¹,

Lehn²,

Rapoport³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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“…9 (13.84%) patients belonged to stage II and 7 24 Approximately 95% of all laryngeal and hypo pharyngeal malignant tumors are Squamous cell carcinoma. In this present series FNAC study show 89% positive finding (i.e., metastatic carcinoma).…”

Section: Discussionmentioning

confidence: 99%

Laryngeal cancer: a clinicopathological study of 65 cases

Chauhan

Bharti

Bhadouriya

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: The larynx serves protective, respiratory and phonatory functions in humans. Cancer of the larynx is common cancer of head and neck region. This study was done to determine the predisposing factors, clinical aspects and histopathological pattern of the laryngeal malignancies. Patients were studied with particular significance given to the mode of presentation, risk factors, topography and histopathology of the tumour.Methods: This prospective study was conducted at Department of Otorhinolaryngology Head and Neck Surgery, Uttar Pradesh University of Medical Sciences, Saifai, Etawah. All 65 cases of laryngeal cancer presented from July 2016 to July 2017were included in this study. Results: Most of cases belonged to age group 51-60 years. Tobacco intake in the form of smoking was the major risk factor and present in 80% of cases. Commonest presenting symptom was the dysphagia followed by hoarseness of voice. Supraglottic area was the commonest site (69.23%) for laryngeal cancer in this study. Squamous cell carcinoma was found in 98.46% of patients. Moderately differentiated category seen in 49.23% of patients. Most of the patients presented in the stage III and IV (30.77% and 44.62%). 37 (56.92%) cases out of 65 cases had cervical lymph node metastasis at the time of presentation.Conclusions:Diagnosis is based on proper history, clinical examination, direct visualization of the larynx, CT scan and established by histopathological examination. This study has been done to improve comprehension and care of patients with laryngeal carcinoma.

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“…Therefore, we expect that induction chemotherapy with TPF (induction TPF) could reduce the risk of distant metastases and consequently lead to improved OS. Locally advanced HNSCC patients harboring diseases classified as nodal stage N2c, N3, or N2b with supraclavicular lymph node (LN) metastases are considered to have the greatest risk of distant metastases [11][12][13][14][15][16]. Thus, our institution has applied induction TPF followed by CRT for patients with a high risk of distant metastases since 2011.…”

mentioning

confidence: 98%

Efficacy and feasibility of docetaxel, cisplatin, and 5-fluorouracil induction chemotherapy for locally advanced head and neck squamous cell carcinoma classified as clinical nodal stage N2c, N3, or N2b with supraclavicular lymph node metastases

et al. 2014

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Clinical Nodal Stage Is an Independently Significant Predictor of Distant Failure in Patients With Squamous Cell Carcinoma of the Larynx

Abstract: Regardless of the index treatment modality, primary tumor site, or T stage, a higher clinical N stage at the time of presentation independently and significantly increases the risk of DM in patients with SCCL.

Cited by 54 publications

References 27 publications

Avaliação da sobrevida livre de doença em pacientes com carcinoma epidermoide de laringe submetidos à tratamento radioterápico exclusivo ou associado à quimioterapia

Avaliação da sobrevida livre de doença em pacientes com carcinoma epidermoide de laringe submetidos à tratamento radioterápico exclusivo ou associado à quimioterapia

Laryngeal cancer: a clinicopathological study of 65 cases

Efficacy and feasibility of docetaxel, cisplatin, and 5-fluorouracil induction chemotherapy for locally advanced head and neck squamous cell carcinoma classified as clinical nodal stage N2c, N3, or N2b with supraclavicular lymph node metastases

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