Clinical Neurophysiology in Disorders of Consciousness

Rossetti, Andrea O.; Laureys, Steven

doi:10.1007/978-3-7091-1634-0

Cited by 7 publications

(1 citation statement)

References 212 publications

(313 reference statements)

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“…Many psychiatric disorders are thought to feature an overgeneralization of fear responses, and this appears to be measurable for some conditions such as generalized anxiety disorders in differential conditioning paradigms (Lissek et al, 2010, 2014). However, as has been noted by others, auditory conditioning may sometimes be necessary as visual stimuli are not applicable for all participants such as children or those with disorders of consciousness (Kotchoubey, 2014; Rossetti & Laureys, 2015). Auditory conditioning paradigms could also provide unique insights into auditory specific symptoms.…”

Section: Discussionmentioning

confidence: 99%

Auditory Aversive Generalization Learning Prompts Threat-Specific Changes in Alpha-Band Activity

Farkas,

Ward,

Gilbert

et al. 2023

Preprint

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Pairing a neutral stimulus with aversive outcomes prompts neurophysiological and autonomic changes in response to the conditioned stimulus (CS+), compared to cues that signal safety (CS-). One of these changes—selective amplitude reduction of parietal alpha-band oscillations— has been reliably linked to processing of visual CS+. It is however unclear to what extent auditory conditioned cues prompt similar changes, how these changes evolve as learning progresses, and how alpha reduction in the auditory domain generalizes to similar stimuli. To address these questions, fifty-five participants listened to three sine wave tones, with either the highest or lowest pitch (CS+) being associated with a noxious white noise burst. A threat specific (CS+) reduction in occipital-parietal alpha-band power was observed similar to changes expected for visual stimuli. No evidence for aversive generalization to the tone most similar to the CS+ was observed in terms of alpha-band power changes, aversiveness ratings, or pupil dilation. By-trial analyses found that selective alpha-band changes continued to increase as aversive conditioning continued, beyond when participants reported awareness of the contingencies. The results support a theoretical model in which selective alpha power represents a cross-modal index of continuous aversive learning, accompanied by sustained sensory discrimination of conditioned threat from safety cues.

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Section: Discussionmentioning

confidence: 99%

Auditory Aversive Generalization Learning Prompts Threat-Specific Changes in Alpha-Band Activity

Farkas,

Ward,

Gilbert

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Electrophysiology in Disorders of Consciousness: From Conventional EEG Visual Analysis to Brain-Computer Interfaces

Chatelle

Lesenfants

Noirhomme

2017

Coma and Disorders of Consciousness

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Auditory aversive generalization learning prompts threat-specific changes in alpha-band activity

Farkas,

Ward,

Gilbert

et al. 2024

Cerebral Cortex

View full text Add to dashboard Cite

Pairing a neutral stimulus with aversive outcomes prompts neurophysiological and autonomic changes in response to the conditioned stimulus (CS+), compared to cues that signal safety (CS−). One of these changes—selective amplitude reduction of parietal alpha-band oscillations—has been reliably linked to processing of visual CS+. It is, however, unclear to what extent auditory conditioned cues prompt similar changes, how these changes evolve as learning progresses, and how alpha reduction in the auditory domain generalizes to similar stimuli. To address these questions, 55 participants listened to three sine wave tones, with either the highest or lowest pitch (CS+) being associated with a noxious white noise burst. A threat-specific (CS+) reduction in occipital–parietal alpha-band power was observed similar to changes expected for visual stimuli. No evidence for aversive generalization to the tone most similar to the CS+ was observed in terms of alpha-band power changes, aversiveness ratings, or pupil dilation. By-trial analyses found that selective alpha-band changes continued to increase as aversive conditioning continued, beyond when participants reported awareness of the contingencies. The results support a theoretical model in which selective alpha power represents a cross-modal index of continuous aversive learning, accompanied by sustained sensory discrimination of conditioned threat from safety cues.

show abstract

Clinical Neurophysiology in Disorders of Consciousness

Cited by 7 publications

References 212 publications

Auditory Aversive Generalization Learning Prompts Threat-Specific Changes in Alpha-Band Activity

Auditory Aversive Generalization Learning Prompts Threat-Specific Changes in Alpha-Band Activity

Electrophysiology in Disorders of Consciousness: From Conventional EEG Visual Analysis to Brain-Computer Interfaces

Auditory aversive generalization learning prompts threat-specific changes in alpha-band activity

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