Clinical mycobacterial diseases of companion animals: part I

O’Halloran, Conor; Dobromylskyj, Melanie

doi:10.12968/coan.2017.22.6.325

Cited by 4 publications

(12 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In light of these findings, it can be concluded that lipocyst and the associated pyogranulomatous panniculitis are not pathognomonic for RGM and cannot be used to distinguish RGM and SGM. Hence, & Dobromylskyj, 2017a) and are increasingly becoming more prevalent worldwide (To et al, 2020). The scarcity of M. avium infection in dogs stems from the natural resistance of this species to the organism.…”

Section: Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous mycobacteriosis caused by Mycobacterium avium subspecies avium in a dog: Clinical findings, histopathological and molecular diagnosis and treatment

Golchin,

Sasani,

Asadian

et al. 2024

Veterinary Medicine & Sci

View full text Add to dashboard Cite

A 3‐year‐old castrated male Jack Russell Terrier with a history of cholestatic hepatitis was presented with a non‐painful and non‐pruritic, subcutaneous nodule following vaccine injection. The dog was otherwise healthy. The nodule was surgically removed. Upon gross inspection, a firm, glistening and loculated tissue was seen within the panniculus. Histopathologically, extensive pyogranulomatous panniculitis was diagnosed, composed of variably sized lipocyst surrounded by neutrophils and an outer zone of foamy epithelioid macrophages, neutrophils and occasional Langhans form giant cells. Although histopathologic findings were most compatible with mycobacteriosis, other infectious and sterile conditions were considered differential diagnoses. Gram, acid‐fast and periodic acid Schiff staining were negative. However, PCR analyses for mycobacterial rpoB gene and sequencing revealed infection with Mycobacterium avium subsp. avium. Empirical treatment was avoided through the 3‐week course of histopathological and molecular investigations. Considering that there were no newly formed cutaneous masses, marbofloxacin (2 mg/kg, PO q24h) was administered for 2 weeks, and clarithromycin was avoided due to its potential cholestatic hepatitis adverse effects. Eight months following surgery, there are no new or relapsing cutaneous lesions or disease‐specific complications. This suggests that marbofloxacin monotherapy may be sufficient in immunocompetent dogs with early detection of localized cutaneous mycobacteriosis lacking lymph node or organ involvement.

show abstract

Section: Case Reportmentioning

confidence: 99%

“…Varying pulmonary and non-pulmonary diseases, including localized, widespread or disseminated cutaneous and gastrointestinal complications with/without generalized or localized lymphadenopathy, have been attributed to NTM (Ghielmetti & Giger, 2020;Mauldin et al, 2016;O'Halloran & Dobromylskyj, 2017a).…”

Section: Introductionmentioning

confidence: 99%

Cutaneous mycobacteriosis caused by Mycobacterium avium subspecies avium in a dog: Clinical findings, histopathological and molecular diagnosis and treatment

Golchin,

Sasani,

Asadian

et al. 2024

Veterinary Medicine & Sci

View full text Add to dashboard Cite

show abstract

“…Mycobacterial infections are a significant cause of morbidity and mortality in human beings and farm animals, and are of increasing clinical significance in companion animal medicine 1–4 . Disease‐causing species are grouped into those that cause tuberculous disease (ie, members of the Mycobacterium tuberculosis complex) and those that cause a non‐tuberculous mycobacteriosis (NTM) 5 …”

Section: Figurementioning

confidence: 99%

“…[1][2][3][4] Disease-causing species are grouped into those that cause tuberculous disease (ie, members of the Mycobacterium tuberculosis complex) and those that cause a non-tuberculous mycobacteriosis (NTM). 5 In human beings, the prevalence of NTM is increasing, with Mycobacterium avium-intracellulare complex (MAC) organisms being isolated in a signiicant proportion of cases. 6 7 Similarly, MAC was identiied as the most common cause of feline NTM in the UK.…”

mentioning

confidence: 99%

Unusual presentation of canine Mycobacterium avium infection

2019

Self Cite

View full text Add to dashboard Cite

This short communication describes the clinical and morphological findings, diagnosis and treatment of a case of Mycobacterium avium infection in a golden retriever that presented with a progressive nasal swelling and lymphadenopathy. Although well documented in cats, where cutaneous lesions are frequently recognised, canine M avium infection is less commonly reported, and cutaneous lesions are rare. To the authors’ knowledge this is the first documented case of canine M avium infection that presented with a cutaneous lesion but no systemic clinical signs. It occurred in a dog with no previously reported breed predisposition and highlights that in cases of cutaneous histiocytic infiltrate in dogs mycobacterial infection should remain a differential diagnosis, even in the absence of suggestive organisms on histopathological examination.

show abstract

“…The former comprises the Mycobacterium tuberculosis ‐complex (MTBC) which is the cause of tuberculosis, while the latter group includes a wide range of mycobacteria with broad environmental and host animal niches. The M. avium ‐complex (MAC) is a distinct taxonomic group of non‐tuberculosis mycobacteria capable of causing opportunistic disease in humans and companion animals (O'Halloran & Dobromylskyj 2017).…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium avium infection associated with sterile polyarthritis in a dog

Gelendi

Taylor

D'Aout

et al. 2021

J of Small Animal Practice

View full text Add to dashboard Cite

A 1‐year‐old male neutered Portuguese Podengo dog was presented for lameness, inappetence, pyrexia, diarrhoea and abdominal moderate to severe lymphadenomegaly. Cytology of synovial fluid revealed neutrophilic inflammation in multiple joints suggestive of immune‐mediated polyarthritis. Cytology of fine‐needle‐aspiration material obtained from lymph nodes revealed macrophages with intracytoplasmic, rod‐like Ziehl‐Neelsen positive staining structures, indicative of mycobacteria. Four‐month treatment with enrofloxacin, rifampicin and clarithromycin resulted in clinical improvement and resolution of polyarthritis as evidenced on repeat synoviocentesis, but diarrhoea recurred, Ziehl‐Neelsen positive organisms were again found on lymph node cytology and analysis of the 16S rRNA‐gene using the Basic Local Alignment Search Tool facility resulted in a match to Mycobacterium avium with 100% sequence identity. Treatment was adjusted to include pradofloxacin, doxycycline, rifampicin and ethambutol and 3 months later the dog is clinically normal. Based on the literature search, this is the first time canine Mycobacterium avium infection associated with immune‐mediated polyarthritis is reported. Based on scoping searches, this is the first report of canine Mycobacterium avium infection associated with immune‐mediated polyarthritis.

show abstract

Clinical mycobacterial diseases of companion animals: part I

Cited by 4 publications

References 51 publications

Cutaneous mycobacteriosis caused by Mycobacterium avium subspecies avium in a dog: Clinical findings, histopathological and molecular diagnosis and treatment

Cutaneous mycobacteriosis caused by Mycobacterium avium subspecies avium in a dog: Clinical findings, histopathological and molecular diagnosis and treatment

Unusual presentation of canine Mycobacterium avium infection

Mycobacterium avium infection associated with sterile polyarthritis in a dog

Contact Info

Product

Resources

About