Clinical–morphological profiles of esophageal carcinoma’s main types

Cameniță, Dan; Demetrian, Alin; Pleşea, Răzvan Mihail; Tănasie-Vasile, Manuela Ioana; Strâmbu, Victor; Grigorean, Valentin Titus; Ioniță, Elena; Pleşea, Iancu Emil; Marincaş, Augustin Marian

doi:10.47162/rjme.61.2.10

Cited by 3 publications

(7 citation statements)

References 33 publications

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“…We read with major interest the recent article of high quality by Cameniţă et al published in this Journal focusing on the morphological profiles of esophageal carcinomas obtained from 46 surgically treated cases [ 1 ]. Esophageal carcinoma is the seventh most common cancer and the sixth cause of death associated with cancers.…”

Section: Dear Editormentioning

confidence: 99%

“…Besides low socioeconomic status, tobacco smoking, alcohol consumption, and diet are synergic risk factors. Predominantly affect males of older age groups, are often found in the lower segments of organ measuring 5 to 10 cm of major diameter, causing stenosis (50%), and often presenting infiltration, protrusion, and ulcerated macroscopic aspect [ 1 ]. Squamous cell carcinoma (SCC) and adenocarcinoma are the two more common histological patterns of esophageal cancers, which usually evolve aggressively, are late-diagnosed, and with different morphological and behavioral profiles.…”

Section: Dear Editormentioning

confidence: 99%

“…Squamous cell carcinoma (SCC) and adenocarcinoma are the two more common histological patterns of esophageal cancers, which usually evolve aggressively, are late-diagnosed, and with different morphological and behavioral profiles. Worthy of note, most of the esophageal carcinomas are classified as poorly differentiated tumors in stage III, and the main histological type (90%) is SCC, with a more elevated incidence in developing countries [ 1 ]. The authors highlighted their following findings: more frequent invasion of the neighboring structures (T4); predominance of a poorly differentiated pattern; uniform distribution of SCCs along the esophagus; less than 20% of distant metastasis (more often detected in the SCCs; and a more accentuated trend to high stages of the SCCs [ 1 ].…”

Section: Dear Editormentioning

confidence: 99%

“…Worthy of note, most of the esophageal carcinomas are classified as poorly differentiated tumors in stage III, and the main histological type (90%) is SCC, with a more elevated incidence in developing countries [ 1 ]. The authors highlighted their following findings: more frequent invasion of the neighboring structures (T4); predominance of a poorly differentiated pattern; uniform distribution of SCCs along the esophagus; less than 20% of distant metastasis (more often detected in the SCCs; and a more accentuated trend to high stages of the SCCs [ 1 ]. Although more frequently invading the structures surrounding the esophagus, there was no description of fistulae.…”

Section: Dear Editormentioning

confidence: 99%

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Letter to the Editor: Esophageal pulmonary fistula and malignancy

Santos¹,

Santos²

2022

Rom J Morphol Embryol

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Section: Dear Editormentioning

confidence: 99%

Section: Dear Editormentioning

confidence: 99%

Section: Dear Editormentioning

confidence: 99%

Section: Dear Editormentioning

confidence: 99%

See 2 more Smart Citations

Letter to the Editor: Esophageal pulmonary fistula and malignancy

Santos¹,

Santos²

2022

Rom J Morphol Embryol

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“…Esophageal cancer (EC, ICD-10 code C15) is a malignancy with poor prognosis, including squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) types. 1 It is estimated that EC incidence is three times higher in males than in females. 2 ESCC is the most common type, with a higher incidence in less developed nations and a list of important risk factors including tobacco smoking, alcohol consumption, a diet low in fruits and vegetables, drinking beverages at high temperatures and Human papillomavirus (HPV) infection.…”

Section: Introductionmentioning

confidence: 99%

Occupational asbestos exposure and risk of esophageal cancer: A systematic review and meta‐analysis

Seyyedsalehi,

Boffetta

2024

Intl Journal of Cancer

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Esophageal cancer (EC), which includes squamous cell carcinoma (ESCC) and adenocarcinoma (EAC), is an important cancer with poor prognosis and high mortality rate. Several occupational exposures have been associated with EC. We aim to investigate the association between occupational asbestos exposure and EC risk, considering types of asbestos and histology of the disease. We included studies mentioned in the list of references in previous reviews and pooled analyses, and we conducted an independent search in PubMed and Scopus. Forest plots of relative risks (RR) were constructed based on the association between occupational asbestos and EC risk. Random‐effects models were used to address heterogeneity between 48 independent cohort and case‐control studies. We found an association between occupational asbestos exposure and EC (meta‐relative risk [RR] = 1.20, 95% confidence interval [CI] = 1.09‐1.32; I2 = 58.8%, p‐heterogeneity [het] <.001). The results of stratification by job (p‐het = .20) indicate an increased RR among asbestos product workers (RR = 1.39, 95% CI = 1.07‐1.81), asbestos applicators (RR = 1.41, 95% CI = 1.20‐1.67), and construction workers (RR = 1.12, 95% CI = 1.02‐1.24). There was no heterogeneity in meta‐RR according to outcome (p = .29), geographic region (p = .69), year of publication (p = .59), quality score (p = .73), asbestos type (p = .93), study design (p = .87), and gender (p = .88), control for potential confounders (p = .20), year of first employment (p = .94) and exposure level (p = .43). The stratification analysis by histology type found an increased RR for both ESCC 1.33(1.03‐1.71) and EAC 1.45(1.03‐2.04) (p‐het = .68). We didn't find evidence of publication bias (p = .07). The results of our study suggest that occupational asbestos exposure is associated with an increased risk of EC in both histology types.

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Esophageal Pleural Fistula in Esophageal Squamous Cell Carcinoma: A Diagnostic Challenge

Salarieh,

Gholami,

Soltani

et al. 2023

Asian Pac J Cancer Biol

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Esophageal pleural fistula (EPF) is a rare but serious complication of esophageal squamous cell carcinoma (ESCC), characterized by an abnormal communication between the esophagus and the pleural space. This abstract provides an overview of EPF in the context of ESCC, focusing on its etiology, clinical presentation, diagnosis, and treatment options. ESCC is a prevalent malignancy worldwide, particularly in regions with a high incidence of tobacco and alcohol consumption. As the tumor progresses, it can invade adjacent structures, including the pleura. The infiltration of the tumor into the pleural space may lead to the formation of an EPF. Patients with EPF often present with symptoms such as cough, dyspnea, chest pain, recurrent pneumonia, or subcutaneous emphysema. However, the clinical manifestations can vary widely, making the diagnosis challenging. Radiological imaging, including contrast-enhanced computed tomography (CT) scans and barium studies, plays a crucial role in detecting the presence and extent of the fistula. The management of EPF in ESCC involves a multidisciplinary approach. Treatment options depend on various factors, including the patient’s overall health status, tumor stage, and extent of the fistula. Conservative measures, such as nutritional support, antibiotics, and drainage of pleural effusion, may be employed in patients who are not surgical candidates. However, the definitive treatment for EPF is usually surgical intervention, which aims to resect the involved segment of the esophagus and repair the fistula. In some cases, palliative strategies, such as stenting or endoscopic interventions, may be considered to alleviate symptoms and improve quality of life. Through this article, we debate on a 47-year-old man presenting with esophageal fistula as the complication of esophageal squamous cell carcinoma. He has always been concerning about dysphagia, however endoscopic biopsies have been unsatisfying till now.

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Clinical–morphological profiles of esophageal carcinoma’s main types

Cited by 3 publications

References 33 publications

Letter to the Editor: Esophageal pulmonary fistula and malignancy

Letter to the Editor: Esophageal pulmonary fistula and malignancy

Occupational asbestos exposure and risk of esophageal cancer: A systematic review and meta‐analysis

Esophageal Pleural Fistula in Esophageal Squamous Cell Carcinoma: A Diagnostic Challenge

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