Clinical morphological analysis of Contegra dysfunction in infants

Zhuravleva, I. Yu.; Ничай, Н. Р.; Dokuchaeva, Anna A.; Soynov, Ilya; Ivantsov, S. M.; Keil, I; Omelchenko, A.Yu.; Gorbatykh, Yu. N.; Горбатых, А. В.

doi:10.21688/1681-3472-2016-1-56-61

Cited by 5 publications

(2 citation statements)

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“…33 Another cause is aseptic inflammation of the xenogenic tissue. 20,21,24,32,34 This process is typical for different biomaterials treated with GA. 12,24,[33][34][35] According to previous studies, epoxy compounds have less cytotoxicity and inflammatory reaction in comparison with GA. 9,10 In our study, there were no cases of conduit failure and reintervention due to neointimal proliferation in the DE-PVC group.…”

Section: Commentmentioning

confidence: 96%

Diepoxy- Versus Glutaraldehyde-Treated Xenografts: Outcomes of Right Ventricular Outflow Tract Reconstruction in Children

Nichay

Zhuravleva

Kulyabin

et al. 2019

World J Pediatr Congenit Heart Surg

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Background: Xenografts used for right ventricular outflow tract (RVOT) reconstruction are typically treated with glutaraldehyde. However, potential benefit of epoxy treatment was demonstrated in experimental studies. We aimed to compare diepoxy-treated bovine pericardial valved conduits (DE-PVCs) and glutaraldehyde-treated bovine pericardial valved conduits (GA-PVCs) for RVOT reconstruction in pediatric patients. Methods: Between 2002 and 2017, 117 patients underwent RVOT reconstruction with PVC in single center: DE-PVC group, n = 39; and GA-PVC group, n = 78. After performing propensity score analysis (1:1) for the entire sample, 29 patients from the DE-PVC group were matched with 29 patients from the GA-PVC group. Results: There were no conduit-related deaths. In the DE-PVC group, the freedom from conduit failure was 90.9% at four years and 54.3% at eight years postoperatively. In the GA-PVC group, it was 46.3% and 33.1%, respectively. The difference was significant ( P = .037). Conduit failure was typically caused by stenosis in both groups. In the DE-PVC group, the main cause of stenosis was xenograft calcification (27.6%); while in the GA-PVC group, it was mostly due to neointimal proliferation (25.0%) and, less often, calcification (14.3%). Conduit thrombosis was the cause of replacement in 6.9% of patients from the GA-PVC group. Conclusions: Diepoxy-treated bovine pericardial valved conduit is a suitable alternative to GA-PVC for RVOT reconstruction in pediatric patients. Diepoxy-treated bovine pericardial valved conduits may be less prone to conduit failure and more resistant to neointimal proliferation and conduit thrombosis than GA-PVCs.

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