Clinical-microbiological parallels of purulent-septic diseases in children

Razin, Maxim; Akselrov, M.A.; Minaev, Sergey; Дьяконов, Д. А.

doi:10.21145/2499-9954-2019-5-62-65

Cited by 3 publications

(3 citation statements)

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“…In bacteriological cultures of biological media of patients with severe purulent-septic diseases, opportunistic microflora and fungi of the genus Candida, which are recognised as pathological agents and are not symbionts of the human body, are increasingly detected [9]. In children with purulent-septic pathology developed against the background of chronic somatic pathology, an unfavourable course of the disease with a high level of chronicity, disability and lethality is noted.…”

Section: Pathogenesis Of Sepsismentioning

confidence: 99%

Ethio-Pathogenesis of Pound Destroyment in Children

K.Z.,

R.I.

2024

tajmspr

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Infectious diseases are one of the most serious problems because they are the most widespread and the leading cause of death. Although significant advances have been made over the past decades in addressing this problem, this statement is still true today. Sepsis is the leading cause of death in critical care patients. It develops in 750000 people each year and more than 210000 of them die. Progress in the study of the pathophysiology and genetic basis of the individual response to sepsis has changed the common understanding of this syndrome, and some therapeutic interventions used in recent years have demonstrated efficacy; however, the problem of intensive care is still quite acute and requires further research.

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Section: Pathogenesis Of Sepsismentioning

confidence: 99%

Ethio-Pathogenesis of Pound Destroyment in Children

K.Z.,

R.I.

2024

tajmspr

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“…В последние десятилетия наблюдается снижение заболеваемости гнойно-во спа ли тельными заболеваниями с количественным изменением нозологического спектра патологии. Это связано с изменениями патоморфоза возбудителей, широким использованием современных методов диагностики, позволяющих добиться полного выздоровления до развития À Архив педиатрии и детской хирургии № 1, июнь 2023 года септических осложнений, а также с использованием новых, эффективных методов хирургического лечения и лекарственных средств [3,4]. При этом, несмотря на почти повсеместное внедрение в практическую хирургию новых информативных методов диагностики, число детей с различными формами аппендикулярного перитонита составляет по данным разных авторов от 6 до 20% случаев.…”

Section: вступлениеunclassified

Evaluation of the effectiveness of ozone therapy in the early postoperative period in children with appendicular peritonitis

Nalyotov,

Strionova,

Rogovoy

et al. 2023

APPS

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The article examines the effectiveness of the use of ozone therapy in the complex treatment of children with appendicular peritonitis at the stage of the early postoperative period in relation to the correction of laboratory indicators of endotoxin aggression and relief of the main clinical symptoms. 60 children operated on for widespread appendicular peritonitis were examined. The main group consisted of 30 children who received a course of ozone therapy in addition to standard complex therapy at the stage of the early postoperative period. Only standard therapy was performed in patients of the comparison group. The control group consisted of 30 healthy children of the same age. Among the patients of the control group, in most cases, its physiological level was established - in 93.3%. The average value of lipopolysaccharides in the group was 0.6±0.1 EU/ml. In turn, among the patients of the main group and the comparison group, all children (100%) showed the development of endotoxin aggression. So, in the main group, the initial average value of lipolysaccharides was 2.6 ± 0.2 EU/ml, and in the comparison group - 2.50.2 EU/ml. 2 weeks after the surgical intervention in patients of the main group, the increased level of lipolysaccharides remained only in 20.0% of children. At the same time, the average value of the indicator was 0.8±0.1 EU/ml. Among the patients of the comparison group, on the 14th day of the postoperative period, 50.0% of children retained an elevated level of lipopolysaccharides, and the average value of the indicator was 1.50.1 EU/ml. It is proved that the use of ozone therapy according to the proposed method at the stage of the early postoperative period in the complex treatment of children with widespread appendicular peritonitis makes it possible to reduce laboratory indicators of endotoxin aggression in a shorter time and accelerate the regression of clinical symptoms.

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“…Так, в результате широкого применения полу синтетических пенициллинов произошло снижение частоты чувстви тельных к ним стафилококковых заболеваний, которые постепенно замещались грамотрицательной флорой. В последние годы вновь наме тилась тенденция к возрастанию роли грамположительных кокковых бактерий, особенно метициллин-резистентного золотистого стафилококка [1-4, 6, 7, 11, 15, 17, 26, 38, 39], штаммы которого характеризуются множественной антибиотикорезистентностью, однако попрежнему на достаточно высоком уровне остается роль грамотрицательной инфекции как основной составляющей условно-патогенной микрофлоры в возникновении этого заболевания [2,8,11,40,41]. Есть данные о роли анаэробной инфекции (Kingella kingae), являющейся облигатным представителем нормальной микрофлоры слизистых оболочек, в возникновении МЭО [2,4,17,41,42], активация которой возникает на фоне иммунодефицитных состояний [37], а также чаще стали встречаться ассоциации микробных возбудителей [10].…”

Section: обзорыunclassified

Modern ideas about metaepiphyseal osteomyelitis. Review

Grishaev,

Shamsiev

2023

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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This paper presents a review of domestic and foreign literature on the issues of diagnosis and treatment of young children with metaepiphyseal osteomyelitis, the changes in the immune system and cytokine levels, and the targeted correction of the disorders that have arisen. This work aims to highlight modern approaches to the diagnosis and treatment of metaepiphyseal osteomyelitis in young children with emphasis on the changes in the immune status of the patient. Literary search was performed in the databases in Russian eLibrary.ru, English Medline, Web of Science, and PubMed using the following keywords: metaepiphyseal osteomyelitis, infants, immune system, cytokines, interleukins, and roncoleukin. A total of 405 papers were found, of which 66 were fully consistent with the purpose of our study and thus selected for the analysis. Results showed that the search for effective methods for the early diagnosis of the osteomyelitic process in young children continues to be relevant; no study has provided a complete picture of the severity of the pathological process. Although numerous studies have been performed, no consensus has been achieved in assessing the significance of changes in the parameters of the immune system and its cytokine link during the development of metaepiphyseal osteomyelitis. The data indicated a positive effect of the use of recombinant interleukin-2 in the complex treatment of a number of diseases, especially in young children with various pathological conditions. Metaepiphyseal osteomyelitis in young children is an urgent problem in pediatric surgery largely due to the increase in the number of children with reduced immuno-biological reactivity, which requires the use of effective immunocorrection agents as part of the complex etiotropic and pathogenetic treatment. This approach applies to such powerful means of immunocorrection as recombinant cytokine preparations.

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Clinical-microbiological parallels of purulent-septic diseases in children

Cited by 3 publications

References 0 publications

Ethio-Pathogenesis of Pound Destroyment in Children

Ethio-Pathogenesis of Pound Destroyment in Children

Evaluation of the effectiveness of ozone therapy in the early postoperative period in children with appendicular peritonitis

Modern ideas about metaepiphyseal osteomyelitis. Review

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