Clinical, metabolic and neurological disorders in full-term newborns from mothers with gestational diabetes mellitus

Ремнева, О. В.; Рожкова, Ольга Владимировна; Черкасова, Т.М.; Кореновский, Ю. В.; Трухачева, Н. В.; Гуревич, Н.Л.

doi:10.21508/1027-4065-2021-66-3-46-51

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…GDM results in a high-risk pregnancy, which can induce complications, such as abortion, premature delivery, amniotic fluid and infection[ 1 , 2 ]. The incidence of fetal distress, polyhydramnios, puerperal infection, premature delivery, and macrosomia in pregnant women with GDM are higher than in those without GDM[ 3 , 4 ]. Pregnancy at the right age is the key to reduce the risk of adverse outcomes.…”

Section: Introductionmentioning

confidence: 99%

Relationship between age of pregnant women with gestational diabetes mellitus and mode of delivery and neonatal Apgar score

Dunstan¹,

Chen²,

Wang³

et al. 2022

WJD

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BACKGROUND Gestational diabetes mellitus (GDM) refers to abnormal glucose tolerance during pregnancy, and it is often accompanied by obvious changes in glucose and lipid metabolism, and associated with adverse pregnancy outcomes. The incidence of fetal distress, polyhydramnios, puerperal infection, premature delivery, and macrosomia in pregnant women with GDM are higher than in those without GDM. AIM To analyze the relationship between age of pregnant women with GDM and mode of delivery and neonatal Apgar score. METHODS A total of 583 pregnant women with GDM who delivered in the Department of Obstetrics at our hospital between March 2019 and March 2022 were selected. Among them, 377 aged < 35 years were selected as the right age group and 206 aged > 35 years were selected as the older group. The clinical data of the two groups were collected, and the relationship between age of the pregnant women with GDM and mode of delivery, maternal and neonatal outcomes, and neonatal Apgar score were compared. In the older group, 159 women were classed as the adverse outcome group and 47 as the good outcome group according to whether they had adverse maternal and infant outcomes. The related factors of adverse maternal and infant outcomes were analyzed through logistic regression. RESULTS The number of women with assisted pregnancy, ≤ 37 wk gestation, ≥ 2 pregnancies, one or more deliveries, and no pre-pregnancy blood glucose screening in the older group were all higher than those in the right age group ( P < 0.05). The natural delivery rate in the right age group was 40.85%, which was higher than 22.33% in the older group ( P < 0.05). The cesarean section rate in the older group was 77.67%, which was higher than 59.15% in the right age group ( P < 0.05). The older group had a higher incidence of polyhydramnios and postpartum hemorrhage, and lower incidence of fetal distress than the right age group had ( P < 0.05). There was no significant difference in neonatal weight between the two groups ( P > 0.05). The right age group had higher Apgar scores at 1 and 5 min than the older group had ( P < 0.05). Significant differences existed between the poor and good outcome groups in age, education level, pregnancy mode, ≤ 37 wk gestation, number of pregnancies, and premature rupture of membranes ( P < 0.05). Logistic regression showed that age, education level and premature rupture of membranes were all risk factors affecting the adverse outcomes of mothers and infants ( P < 0.05). CONCLUSION Delivery mode and Apgar score of pregnant women with GDM are related to age. Older age increases the adverse outcome of mothers and infants.

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Section: Introductionmentioning

confidence: 99%

Relationship between age of pregnant women with gestational diabetes mellitus and mode of delivery and neonatal Apgar score

Dunstan¹,

Chen²,

Wang³

et al. 2022

WJD

View full text Add to dashboard Cite

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Neonatal outcomes in women with diabetes mellitus — analysis of DAPSY data

Kapustin,

Kopteeva,

Alekseenkova

et al. 2024

Journal of obstetrics and women's diseases

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BACKGROUND: Hyperglycemia in pregnancy is associated with short- and long-term implications for children. Nevertheless, the effects of different types of diabetes mellitus and treatment methods on the neonatal outcomes are to be investigated. AIM: The aim of this study was to evaluate the contribution of different types of maternal diabetes mellitus to the risk of adverse neonatal outcomes. MATERIALS AND METHODS: This retrospective cohort study included women (n = 3261) who delivered at the Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia in 2008–2017. The following comparison groups were used: type 1 diabetes mellitus (n = 506; 1a, continuous subcutaneous insulin injections; 1b, multiple daily insulin injections), type 2 diabetes mellitus (n = 229; 2a, diet; 2b, insulin therapy), gestational diabetes mellitus (n = 2387; 3a, diet; 3b, insulin therapy), and control (n = 139). The main birth outcomes assessed included weight and length of newborns, Apgar score at birth and at 5 minutes after birth, and pathological conditions such as fetal macrosomia, syndrome of infant of mother with gestational diabetes mellitus or diabetic mother (P70.0–P70.1), light (P05.0) or small for gestational age (P05.1), intrauterine growth restriction, prematurity (P07), neonatal hypoglycemia (P70.4), and neonatal respiratory distress syndrome (P22). The secondary birth outcomes assessed included birth trauma (P10–P15), stillbirth (P95), disturbances of cerebral status of newborn (P91), and congenital malformations, deformations and chromosomal abnormalities (Q00–Q99). RESULTS: Pregestational diabetes mellitus is strongly associated with adverse neonatal outcomes. Type 1 diabetes mellitus women had the highest risks for fetal macrosomia and diabetic fetopathy, neonatal hypoglycemia, prematurity, and congenital malformations (odds ratio 3.54, 20.2, 5.59, 4.24 and 3.92 respectively). In type 2 diabetes mellitus patients, the risks of low birth weight, intrauterine growth restriction and birth trauma (odds 9.14, 5.42 and 6.3 respectively) were higher. For women with gestational diabetes mellitus, these risks were lower. CONCLUSIONS: This study provides a comprehensive analysis of the major neonatal pathology in patients with different types of diabetes mellitus, taking into account the treatment method. Preconception care and optimal glycemic control are necessary to reduce the risk of obstetric and perinatal complications in women with pregestational types of diabetes mellitus. Further research into the health status of this cohort of children at a later age is required.

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Clinical, metabolic and neurological disorders in full-term newborns from mothers with gestational diabetes mellitus

Cited by 2 publications

References 8 publications

Relationship between age of pregnant women with gestational diabetes mellitus and mode of delivery and neonatal Apgar score

Relationship between age of pregnant women with gestational diabetes mellitus and mode of delivery and neonatal Apgar score

Neonatal outcomes in women with diabetes mellitus — analysis of DAPSY data

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