Clinical manifestations of respiratory adenoviral infection among hospitalized children in <scp>K</scp>orea

Kwon, Hyo Jin; Rhie, Young Jun; Jang, Gi Young; Choi, Byung Min; Lee, Jung Hwa; Lee, Chang Kyu; Kim, Yun Kyung

doi:10.1111/ped.12108

Cited by 14 publications

(17 citation statements)

References 24 publications

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“…ADV infection in the present study occurred at a median age of 29 months, and in agreement with previous reports, occurred more frequently in males than in females [39192223]. All children except one complained of fever on admission, with fever lasting for a median of 6 days, as is consistent with published reports [34192223].…”

Section: Discussionsupporting

confidence: 93%

“…All children except one complained of fever on admission, with fever lasting for a median of 6 days, as is consistent with published reports [34192223]. Respiratory symptoms were most frequent, followed by gastrointestinal symptoms, and this was comparable with previous data [222324].…”

Section: Discussionsupporting

confidence: 91%

“…Adenovirus (ADV) is one of the most common respiratory pathogens in childhood, and 13-17% of children hospitalized with a viral respiratory tract infection are diagnosed with an ADV infection [123]. Although most cases are self-limiting [34], ADV infection can lead to more severe complications and death.…”

Section: Introductionmentioning

confidence: 99%

“…Although most cases are self-limiting [34], ADV infection can lead to more severe complications and death. Specific serotypes of the ADV (serotypes 1, 3, 5, 7, 8, 21, and 55), a younger age (less than one year), and immunocompromised hosts have been reported as risk factors for severe ADV infection [567891011].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

et al. 2016

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BackgroundAlthough adenovirus (ADV) infection occurs steadily all year round in Korea and the identification of respiratory viral coinfections has been increasing following the introduction of multiplex real-time polymerase chain reaction tests, the clinical impact of viral coinfection in children with ADV infection has rarely been reported.Materials and MethodsMedical records of children diagnosed with ADV infection were retrospectively reviewed. The enrolled children were divided into two groups based on the identified respiratory viruses: ADV group and coinfection group. Clinical and laboratory parameters were compared between the two groups.ResultsIn total, 105 children (60 males and 45 females) with a median age of 29 months (range: 0-131 months) diagnosed with an ADV infection were enrolled. Fever (99.0%) was by far the most frequent symptom, followed by respiratory (82.9%), and gastrointestinal (22.9%) symptoms. Upper and lower respiratory tract infections were diagnosed in 56 (53.3%), and 32 (30.5%) children, respectively. Five (4.8%) children received oxygen therapy, and no child died due to ADV infection. Coinfection was diagnosed in 32 (30.5%) children, with rhinovirus (46.9%), and respiratory syncytial virus (21.9%) being the most frequent. The proportions of children younger than 24 months (P <0.001), with underlying medical conditions (P = 0.020), and diagnosed with lower respiratory tract infection (P = 0.011) were significantly higher in the coinfection group than in the ADV group. In a multivariate analysis, only the younger age was significantly associated with coinfection (P <0.001). Although more children in the coinfection group received oxygen therapy (P = 0.029), the duration of fever and hospitalization was not significantly different between the two groups.ConclusionRespiratory viral coinfection with ADV occurred more frequently in children younger than 24 months of age compared with children aged 24 months or older. Respiratory viral coinfection may increase the severity of ADV infection, however, appropriate therapy prevented prolonged hospitalization and poor prognosis due to coinfection.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

et al. 2016

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“…For example, in the transplant unit of St. Anna Children's Hospital, Vienna, Austria, HAdV species C accounts for about 80% of all adenoviral infections observed, and similar numbers were also reported from other transplant centers in different geographic regions (43,69,(71)(72)(73). Sequential or concomitant coinfections with different adenoviruses from the same or different species are quite commonly observed in both the immunocompetent and immunocompromised patient settings (74)(75)(76) and may thus play a role in the generation of recombinant HAdV types.…”

Section: Prevalence Of Hadv Species and Typesmentioning

confidence: 78%

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

2014

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SUMMARY Human adenoviruses (HAdVs) are an important cause of infections in both immunocompetent and immunocompromised individuals, and they continue to provide clinical challenges pertaining to diagnostics and treatment. The growing number of HAdV types identified by genomic analysis, as well as the improved understanding of the sites of viral persistence and reactivation, requires continuous adaptions of diagnostic approaches to facilitate timely detection and monitoring of HAdV infections. In view of the clinical relevance of life-threatening HAdV diseases in the immunocompromised setting, there is an urgent need for highly effective treatment modalities lacking major side effects. The present review summarizes the recent progress in the understanding and management of HAdV infections.

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Epidemiology of human adenovirus infection in children hospitalized with lower respiratory tract infections in Hunan, China

Xie

Zhang

Xiao

et al. 2018

Journal of Medical Virology

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To investigate the current genotypes of circulating human adenovirus (HAdV) strains, we molecularly genotyped HAdV in the nasopharyngeal aspirates (NPAs) of patients with acute lower respiratory tract infections (ALRTIs) and attempted to determine their associations with clinical symptoms. A total of 4751 NPA samples were collected from 4751 patients admitted to Hunan Provincial People's Hospital from September 2007 to March 2014, of which 447 (9.4%) samples were HAdV positive. Fourteen different HAdV types were identified; HAdV types 1 to 7 (HAdV 1‐7) were identified in 95.7% of the 447 NPA samples with HAdV‐7 and HAdV‐3 being the most prevalent. In addition, 93.3% (417 of 447) of patients were younger than 5 years. The incidence of HAdV infection peaked in summer. Different HAdV types showed a predilection for different age groups and different seasonal distribution patterns. Coinfection of HAdVs and other respiratory viruses was detected in 63.3% (283 of 447) of the HAdV‐positive samples. The most common clinical diagnosis was pneumonia and the most common symptoms were fever and cough. In comparison with children infected with HAdV‐3 alone, those infected with HAdV‐7 alone had an increased frequency of severe pneumonia involvement (11.6% vs 32.4%; P = 0.031), higher intensive care unit admission rates (7.0% vs 26.5%; P = 0.019), and a longer length of hospital stay (P = 0.03). Mixed infections in younger children were associated with a longer hospital stay (P = 0.023). Our results demonstrate the recent changes in the trends of circulating HAdV genotypes associated with ALRTIs in Hunan China.

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Clinical manifestations of respiratory adenoviral infection among hospitalized children in Korea

Abstract: Our study demonstrates that respiratory adenovirus infections are an important cause of hospitalization in young children, and contribute to a significant morbidity.

Cited by 14 publications

References 24 publications

Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

Epidemiology of human adenovirus infection in children hospitalized with lower respiratory tract infections in Hunan, China

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