Clinical Manifestations of Recurrent Parotid Pleomorphic Adenoma

Suh, Myung‐Whan; Hah, J. Hun; Kwon, Seong Keun; Jung, Young Ho; Kwon, Taekyoung; Kim, Kwang Hyun; Sung, Myung‐Whun

doi:10.3342/ceo.2009.2.4.193

Cited by 39 publications

(43 citation statements)

References 21 publications

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“…The treatment of PA is surgical excision. Because of its pseudocapsule and fingerlike projections, failure to resect some normal surrounding parotid tissue with the tumor usually results in a high recurrence rate (20%–45%) (6). Pleomorphic adenoma is classified by the World Health Organization as a benign neoplasm of the salivary glands characterized by cellular and architectural pleomorphism (7).…”

Section: Discussionmentioning

confidence: 99%

Parotid Tail Pleomorphic Adenoma Extending to the Parapharyngeal Space

Polat

Doğan

Yüce

et al. 2013

Journal of Craniofacial Surgery

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Parapharyngeal space tumors are rare, accounting for 0.5% of head and neck neoplasms. Most of them are benign and originate in the salivary glands, especially the pleomorphic adenoma. We presented a 47-year-old male with parotid tail pleomorphic adenoma extending to the parapharyngeal space. The patient applied to our clinic with the complaints of a painless mass on his neck and in his mouth for three months. After fine needle aspiration biopsy the mass was diagnosed as pleomorphic adenoma. The patient hospitalized and operated in our clinic. As we see in literature review parapharyngeal space tumors are rare and most of them are pleomorphic adenomas arising from deep lobe of the parotid gland and extend into the PPS.

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Section: Discussionmentioning

confidence: 99%

Parotid Tail Pleomorphic Adenoma Extending to the Parapharyngeal Space

Polat

Doğan

Yüce

et al. 2013

Journal of Craniofacial Surgery

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“…13 Initially believed to be primarily due to tumor spillage during excision, recurrence may also be due to unique histological and genetic characteristics. 12 Additionally, the presence of microscopic satellite tumors left behind after resection has been reported to contribute to pleomorphic adenoma recurrence. 13 More recently there has been an interest in determining the expression profile of various tumor marker genes to determine if particular expression patterns exist between pleomorphic adenomas and their malignant counterparts.…”

Section: Discussionmentioning

confidence: 99%

“…11 The incidence of recurrent pleomorphic adenoma has been reported as high as 17%, depending on the surgical technique used in the primary excision. 12 Pleomorphic adenomas are not all truly encapsulated; rather some possess "pseudopodia" that vary in thickness and extend from the tumor surface, contributing to postoperative recurrence. 13 Initially believed to be primarily due to tumor spillage during excision, recurrence may also be due to unique histological and genetic characteristics.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2012

J Neurol Surg Rep

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A 53-year-old man presented to the emergency department with a 7-day history of right ear fullness, otalgia, and hearing loss. He had recently been treated with antibiotics for sinusitis at an outside hospital but his symptoms failed to resolve. He denied vertigo, dizziness, otorrhea, or tinnitus. Physical examination demonstrated a mass behind an intact right eardrum, and tuning fork evidence of a conductive hearing loss. The remainder of his cranial nerve examination was normal, with the exception of the long-standing HouseBrackmann Grade VI/VI right facial nerve paralysis. Audiogram demonstrated a right moderate conductive hearing loss with flat (Type B) tympanogram. The left side was normal.The patient had a right parotid pleomorphic adenoma 35 years ago, which was treated by enucleation. He presented with several subcutaneous nodules 7 years after the initial treatment, which were treated by total parotidectomy. During surgery the facial nerve was sacrificed due to tumor encasement. Pathology confirmed recurrent pleomorphic adenoma. Postoperatively the tumor bed was treated with external beam radiotherapy. After this he remained asymptomatic for nearly 30 years.Magnetic resonance imaging of the head confirmed a large, irregular, heterogeneous, and variably enhancing mass in the right mastoid with extension medially along the floor of the posterior fossa measuring $5 Â 5 Â 5 cm (►Fig. 1). The mass eroded through the mastoid laterally and inferiorly into the upper cervical soft tissues. The superior portions of the mastoid were opacified with enhancement, suggesting tumor infiltration. The mass extended inferiorly into the parapharyngeal space and extrinsically compressed the right sigmoid sinus displacing it medially. In addition, a 1 Â 1 cm enhancing nodule in the right cerebellum medial to the cystic lesion was observed. The differential diagnosis at this point included carcinoma ex AbstractPleomorphic adenoma, also known as benign mixed tumor, is the most common tumor affecting the parotid gland and can reach massive size; however, intracranial invasion is rare. Recurrence of pleomorphic adenoma after excision is a well-known phenomenon and can present decades after resection of the primary tumor. Here we present the case of a 53-year-old man who presented to our clinic with ear fullness, otalgia, and hearing loss 30 years after undergoing total parotidectomy and external beam radiotherapy for pleomorphic adenoma. Magnetic resonance imaging revealed a massive transcranial tumor invading the mastoid cavity, the dura of the posterior fossa, the fallopian and semicircular canals, the jugular foramen, the lateral infratemporal fossa skull base, the sigmoid and transverse sinuses, and the superior parapharyngeal region. Gross examination and histopathological studies confirmed that the mass was a recurrent pleomorphic adenoma. Here we discuss the features of recurrent pleomorphic adenoma and review the current literature.

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“…Because these tumors become more aggressive after each procedure with subsequent increased risk of malignant transformation [21], early diagnosis, treatment and routine follow up are essential. The current patient underwent a superficial parotidectomy with wide soft tissue margins and has had an uneventful follow-up period.…”

Section: Discussionmentioning

confidence: 99%

37 Recurrent Pleomorphic Adenoma

Pensak¹

2010

Otolaryngology Cases

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Clinical Manifestations of Recurrent Parotid Pleomorphic Adenoma

Cited by 39 publications

References 21 publications

Parotid Tail Pleomorphic Adenoma Extending to the Parapharyngeal Space

Parotid Tail Pleomorphic Adenoma Extending to the Parapharyngeal Space

Untitled

37 Recurrent Pleomorphic Adenoma

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