Clinical Manifestations of Overactive Bladder With Migraine as a Comorbidity: A Prospective Cross-Sectional Study

Abstract

Purpose: The aim of this study was to investigate the clinical manifestations of overactive bladder (OAB) with migraine as a comorbidity and to shed light on possible new treatment strategies.Methods: This study included patients aged 18 years and older who were admitted to urology and neurology outpatient clinics between March 1, 2019 and March 1, 2020 for OAB and migraine. The study questionnaire contained 3 sections: (1) questions on demographic characteristics, (2) a migraine ID test, and (3) the Overactive Bladder Inquiry Form - V8 (OAB-V8) form.Results: A total of 265 patients participated in the study. The average age of the participants was 39.75±11.93 years. The patients were divided into 3 groups according to the coexistence of OAB with migraine: group 1, OAB(+)/migraine(+); group 2, OAB(+)/migraine(-); and group 3, OAB(-)/migraine(+). The mean OAB-V8 score was 22.82 ±8.15 in group 1 and 25.64±7.49 in group 2. The mean OAB-V8 score of OAB patients with migraine as a comorbidity was statistically significantly lower than that of OAB patients without migraine (P=0.015). The median visual analogue scale (VAS) score was 7.11 (range, 2–10) in group 1 and 5.95 (range, 2–10) in group 3. This finding indicates that in patients with migraine, having OAB was associated with significantly higher VAS scores (P<0.001).Conclusions: OAB and migraine may be comorbid conditions coexisting in a single patient. This comorbidity may lead to a lower perception of OAB symptoms in OAB patients or, conversely, to a higher perception of migraine pain. Further studies are needed to elucidate how treatments for each of these diseases can affect the other disease.

Black box in overactive bladder: Central sensitization and its relationship with urinary symptom severity and quality of life

“…Many conditions, including temporomandibular joint disorders, fibromyalgia, chronic fatigue syndrome, headache, complex regional pain syndrome, and IBS, are defined as syndromes associated with CS. 5 It is known that nonurological symptoms are more common in OAB patients than in the general population. Previous studies have found that OAB frequently occurs together with different types of headaches.…”

“…Clinically, CS is explained to contribute to the pathophysiology of functional somatic syndromes, somatoform disorders, medically unexplained conditions, and chronic pain. 4,5 It has also been reported that patients with CS experience altered pain perception, decreased pain threshold, referred pain, and allodynia, and that there is psychosocial impact and QoL is affected. 4 Multiple possible mechanisms have been reported in the pathophysiology of OAB, including myogenic, neurogenic, and idiopathic factors.…”

Applications of artificial intelligence in urological setting: a hopeful path to improved care

“…Various methods and learning algorithms for motion recognition have been proposed. Most studies have used static algorithms such as ANNs ( Karmonik et al, 2019 ; Kim et al, 2020 ; Nikkola et al, 2020 ; Prabhakar et al, 2019 ) and K-means clustering ( Baser et al, 2020 ; Fraley and Raftery, 2002 ; Moon and Cho, 2021 ), or dynamic time warping ( Powar and Chemmangat, 2019 ) in combination with algorithms. However, a time series algorithm should be used to predict or classify dynamically changing time series data.…”

How effectively do we apply first-line treatment in overactive bladder?

“…Although many methods are used in the treatment of OAB, fluid intake modification, restriction of caffeine and tea, weight reduction, bladder training, which constitute behavioral therapy, are recommended in the first-line treatment. Furthermore, in addition to behavioral therapy, pelvic floor muscle training (PFMT) and antimuscarinic and/or beta3-agonist therapy may be implemented in the first-line treatment [5,6]. Patients who were nonrespondent to the first-line treatment may undergo therapeutic methods such as intravesical botulinum toxin administration, posterior tibial nerve stimulation, and sacral neuromodulation [7].…”