Clinical manifestations of lyme disease

Steere, Allen C.; Bartenhagen, Nicholas H.; Craft, Joseph; Hutchinson, Gordon J.; Newman, James H.; Pachner, Andrew R.; Rahn, Daniel W.; Sigal, Leonard H.; Taylor, Elise; Malawista, Stephen E.

doi:10.1016/s0176-6724(86)80123-7

Cited by 48 publications

(43 citation statements)

References 9 publications

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“…In humans, Lyme borreliosis is a disease caused by infection with Borrelia burgdorferi [1]. B. burgdorferi is transmitted by infected ticks belonging primarily to the Ixodes ricinus complex [2].…”

Section: Introductionmentioning

confidence: 99%

Comparison in the immunological properties ofBorrelia burgdorferiisolates fromIxodes ricinusderived from three endemic areas in Switzerland

Leuba-Garcia

Kramer

et al. 1994

Epidemiol. Infect.

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SUMAIMARYBorrelia burgdorferi isolates were obtained from Ixodes ricinus from three sites in Switzerland. They were examined by SDS-PAGE and immunoblotting. The phenotypes, in respect of three outer surface proteins (Osp), differed between the sites of collection. In site 1, most isolates had an OspA of 31 kDa and an OspB of 34 kDa; in site 2, isolates presenting an OspA of 33 kDa dominated and in site 3, the isolates with an OspA of 32 kDa and an OspB of 35 kDa were most frequent. This distribution differed significantly. About half of the isolates from sites 1 and 3 reacted with anti-OspA monoclonal antibody H5332 compared to 29 % from site 2. Site 1 isolates reacted significantly more frequently (81 %) with another antiOspA monoclonal antibody LA-31 than isolates from site 3 (P < 0 0001). These findings have implications for the epidemiology of Lyme borreliosis, for the further development of serodiagnostic reagents and for the development of a vaccine.

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Section: Introductionmentioning

confidence: 99%

Comparison in the immunological properties ofBorrelia burgdorferiisolates fromIxodes ricinusderived from three endemic areas in Switzerland

Leuba-Garcia

Kramer

et al. 1994

Epidemiol. Infect.

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“…In humans, B. burgdorferi infection commonly results in a pathognomonic skin rash named erythema migrans, and persistent infection can lead to the development of Lyme arthritis (36,66,67). Human Lyme arthritis is associated with CD4…”

mentioning

confidence: 99%

Coinfection withBorrelia burgdorferiand the Agent of Human Granulocytic Ehrlichiosis Alters Murine Immune Responses, Pathogen Burden, and Severity of Lyme Arthritis

et al. 2001

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Lyme disease and human granulocytic ehrlichiosis (HGE) are tick-borne illnesses caused by Borrelia burgdorferi and the agent of HGE, respectively. We investigated the influence of dual infection with B. burgdorferi and the HGE agent on the course of murine Lyme arthritis and granulocytic ehrlichiosis. Coinfection resulted in increased levels of both pathogens and more severe Lyme arthritis compared with those in mice infected with B. burgdorferi alone. The increase in bacterial burden during dual infection was associated with enhanced acquisition of both organisms by larval ticks that were allowed to engorge upon infected mice. Coinfection also resulted in diminished interleukin-12 (IL-12), gamma interferon (IFN-␥), and tumor necrosis factor alpha levels and elevated IL-6 levels in murine sera. During dual infection, IFN-␥ receptor expression on macrophages was also reduced, implying a decrease in phagocyte activation. These results suggest that coinfection of mice with B. burgdorferi and the HGE agent modulates host immune responses, resulting in increased bacterial burden, Lyme arthritis, and pathogen transmission to the vector.

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“…Our patient, just like many other presented patients in other cases, is young, with no health problems, with the history of rash and acquired AV block of all types, so we decided to do electrophysiology study, based on suspected Lyme borreliosis. The clinical expression of Lyme disease is highly variable, but the most common cardiac manifestation is AV block [10][11][12][13] . Van der Linde, in a review of the clinical characteristics of 66 cases of Lyme carditis in Europe and 39 cases from the US, found that complete heart block was the most common form of AV block in the both groups.…”

Section: Discussionmentioning

confidence: 99%

“…Kao i bolesnici prezentirani u drugim sluËajevima, naπ bolesnik nije imao ranije zdravstvene tegobe, ali je navodio osip te se prezentirao sa steËenim AV blokovima svih stupnjeva zbog Ëega smo se odluËili uËiniti elektrofizioloπko ispitivanje uslijed postavljene sumnje na Lyme boreliozu. KliniËka manifestacija lymske bolesti je izrazito varijabilna, pri Ëemu se najËeπÊe kod zahvaÊenosti srca javljaju AV blokovi [10][11][12][13] . Naime, Van der Linde je u preglednom Ëlanku o kliniËkim karakteristikama lyme karditisa kod 66 sluËajeva u Europi i 39 sluËajeva u SAD-u zakljuËio da je totalni AV blok bio najËeπ-Êi oblik AV bloka u obje skupine.…”

Section: Raspravaunclassified

Approach to a patient with conduction disturbance caused by Lyme borreliosis.

Kurtić¹,

Meštrović²,

Zeljko³

et al. 2014

Cardiol Croat.

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2014;9(1-2):40. Cardiologia CROATICA Uvod U Europi se Lyme borelioza kardioloπki manifestira u oko 0,5% do 4,0% sluËajeva, meutim neke studije navode razvoj kardijalnih komplikacija i do 10% nelijeËenih bolesnika s infekcijom koju uzrokuje Borrelia burgdorferi 1,2 . Lajmska bolest se javlja sa sliËnom prevalencijom u oba spola te zahvaÊa ljude sve dobi, meutim, neki autori navode drugaËi-ju prevalenciju lyme karditisa ovisno o spolu 3,4 . Lyme karditis se prezentira najËeπÊe kao poremeÊaj atrioventrikulskog (AV) provoenja, pri Ëemu se najËeπÊe javlja prolongacija PR intervala, koji progredira u oko 50% tih bolesnika u totalni AV blok 5 . Napominje se da se u istog bolsnika mogu intermitentno javiti razliËiti stupnjevi AV provoenja 6 . Totalni AV blok tipiËno spontano prolazi (u viπe od 90% bolesnika) unutar tjedan dana, a manje teπki poremeÊaji provoenja unutar πest tjedana 7 . Postavljanje dijagnoze lyme karditisa moaee biti veoma zahtjevno, a kada se naglo razvije AV blok nepoznate etiologije potrebni je uzeti u obzir lyme karditis, posebice u mladih ljudi 6 . Eritema migrans, kao izrazito specifiËan simptom akutne faze bolesti Ëesto nije prisutan u svim sluËajevima 8 , zbog Ëega postoji potreba za jasnim testom potvrde kliniËke sumnje -seroloπka pretraga kao πto je imunoapsorpcijski

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Clinical manifestations of lyme disease

Cited by 48 publications

References 9 publications

Comparison in the immunological properties ofBorrelia burgdorferiisolates fromIxodes ricinusderived from three endemic areas in Switzerland

Comparison in the immunological properties ofBorrelia burgdorferiisolates fromIxodes ricinusderived from three endemic areas in Switzerland

Coinfection withBorrelia burgdorferiand the Agent of Human Granulocytic Ehrlichiosis Alters Murine Immune Responses, Pathogen Burden, and Severity of Lyme Arthritis

Approach to a patient with conduction disturbance caused by Lyme borreliosis.

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