Clinical Manifestations of Leprous Rhinitis

Barton, R. P. E.

doi:10.1177/000348947608500113

Cited by 26 publications

(37 citation statements)

References 5 publications

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“…These facial deformities findings are based on the assertion that each subdivision by variation of the host resistance is flexibly shifted [3]. …”

Section: Discussionmentioning

confidence: 99%

“…Findings in the nasal cavity have been useful in the diagnosis of leprosy [2]. And among them, nasal deformities proceed, in sequence, from nasal mucosal atrophy to invasive nodules, septal perforations, columellar retraction, and the saddle nose [3]. The invading bacillus has three main targets: peripheral neural tissues (Schwann cells), small vessels, and monocytes [4].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Facial Deformities in Korean Leprosy

Kim

Lee

et al. 2013

Clin Exp Otorhinolaryngol

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ObjectivesThe clinical features of various facial deformities in Korean leprosy patients were evaluated according to the type of leprosy.MethodsOne hundred ninety six patients with leprosy were examined for various facial deformities using a nasal speculum, endoscope, and digital camera. The frequency and severity of external nasal deformities and septal perforations were evaluated according to the type of leprosy. Eye deformities, ear deformities, and facial palsy were also assessed.ResultsSeventy-one patients (36.2%) displayed external nasal deformities: 28 minimal contractures, three cartilage contractures, two bony-cartilage contractures, and 38 skin defects. The external nasal deformity and severe form deformity in lepromatous types were more frequent compared to other types (P<0.05 for each variable). Twenty-three patients (9%) displayed septal perforations, among whom 11 had cartilaginous perforations and 12 had bony-cartilaginous perforations. The frequency of septal and bony-cartilaginous perforations did not differ significantly between the types of leprosy (P>0.05 for each variable). Sixty-one patients (31.1%) had eye deformities and 19 patients (9.7%) had facial nerve palsy, common in the borderline type. No cases of ear deformities were observed.ConclusionKorean patients had characteristic deformities according to the type of leprosy. They were different from those seen in the prior analyses of Caucasian populations.

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“…These facial deformities findings are based on the assertion that each subdivision by variation of the host resistance is flexibly shifted [3]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of Facial Deformities in Korean Leprosy

Kim

Lee

et al. 2013

Clin Exp Otorhinolaryngol

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“…Their mean age was 68.6 years (range 53-82) and the mean disease duration was 48.4 years (range 30-65; Table 1). The Ridley-Jopling classification system [15] was used to confirm the diagnosis of lepromatous leprosy. Septal perforation was observed in 11 (73%) patients during the examination.…”

Section: Methodsmentioning

confidence: 99%

“…Few studies of olfactory dysfunction in leprosy have been published in the English medical literature [1,[14][15][16]. Furthermore, the number of patients who lose the function of smell is not known.…”

Section: Introductionmentioning

confidence: 99%

Olfactory Dysfunction and Olfactory Bulb Volume Reduction in Patients with Leprosy

Veyseller

Aksoy

Yıldırım

et al. 2011

Indian J Otolaryngol Head Neck Surg

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To ascertain the level and rate of olfactory dysfunction in patients with leprosy and to determine whether olfactory bulb volume is affected by the pathophysiology. Olfactory bulb (OB) volume, measured using magnetic resonance imaging (MRI), was compared in 15 patients with leprosy and 15 healthy controls. All of the participants were evaluated using a detailed history to identify the probable causes of the smell dysfunction. Those who had a disease other than leprosy that may have caused the smell dysfunction were excluded from the study. OB volumes were calculated by manually tracing the OB on coronal sections. Orthonasal olfaction testing was used to assess smell function. The orthonasal olfaction testing indicated that all patients with leprosy were anosmic or severely hyposmic. The smell function test indicated that the OB volume of the patient group was significantly lower than that of the control group. No within-group difference was detected between right and left OB volume in either group. The patients in the leprosy group were severely hyposmic or anosmic and their olfactory bulb volume was significantly lower than that of the control group. To our knowledge, this study is the first to show a reduction in olfactory bulb volume among leprosy patients.

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“…The nasal mucosa has been shown to be affected by M. leprae 35 and probably serves as a portal of entry for infection. The nasal mucosa is involved in 95% of patients with lepromatous leprosy 36 and has been found to be affected in all patients with advanced lepromatous disease.…”

Section: A Infections Causing Nasal Septal Ulceration Tuberculosismentioning

confidence: 99%