Clinical Manifestations of IgE Hypogammaglobulinemia

Selective IgE deficiency and cardiovascular diseases

“…30 As mentioned previously, IgED is characterized by chronic inflammation, immune dysregulation, and autoimmunity. 4,5 It is accepted that systemic autoimmune diseases are similarly characterized by chronic inflammation and immune dysregulation. Therefore, some investigators postulate an autoimmune nature for atherosclerosis.…”

“…3 Patients with IgE hypogammaglobulinemia were found to have an increased prevalence of multiple immunoglobulin deficits, autoimmune disease, and nonallergic reactive airway disease when compared with a population of patients with normal to elevated IgE levels. 4 Recently, we described a relatively large group of patients with undetectable serum total IgE and found that IgE less than or equal to 2 kIU/L may serve as a marker of immune dysregulation and autoimmunity. 5 IgE is thought to be potentially atherogenic through its proinflammatory influence on mast cells and platelets.…”

Chronic Sinopulmonary Inflammatory Diseases in Adults with Undetectable Serum IgE in Inner-City Chicago: A Preliminary Observation

“…While several studies have reported an increased prevalence of chronic sinopulmonary inflammatory diseases in patients with selective IgE deficiency, including rhinosinusitis, chronic bronchitis, and asthma, other investigators were unable to reproduce this observation [5][6][7][8][9]. For example, Smith et al [5] reported that 32 of 44 adult patients (73%) with a serum total IgE level B2.5 IU/mL in rural eastern Tennessee had physician-diagnosed asthma compared to 20% in those with a normal or an elevated serum total IgE level.…”

“…For example, Smith et al [5] reported that 32 of 44 adult patients (73%) with a serum total IgE level B2.5 IU/mL in rural eastern Tennessee had physician-diagnosed asthma compared to 20% in those with a normal or an elevated serum total IgE level. The prevalence of chronic rhinosinusitis was not reported.…”

Low immunoglobulin E flags two distinct types of immune dysregulation

“…Surprisingly little is known about clinical entities that present with a low IgE result. Low serum IgE has been associated clinically with chronic fatigue and polyarthralgias [8] and a higher prevalence of autoimmune and oncological diseases and asthma, as well as chronic sinusitis and otitis media [9]. Recent studies found an association between low serum IgE levels and the levels of one or more classes of immunoglobulins (i.e.…”