Clinical Manifestations of Celiac Disease

Green, Peter H R; Krishnareddy, Suneeta; Lebwohl, Benjamin

doi:10.1159/000370204

Cited by 33 publications

(26 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This suggests that there is greater inflammatory response than expected or that the removal of microbial products from the blood is less effective than is the case with normal subjects (21,22). …”

Section: Discussionmentioning

confidence: 97%

Celiac disease prevalence in patients with hydatid cyst

Poyrazoglu¹,

Dönder²,

Dülger³

et al. 2017

J Turgut Ozal Med Cent

View full text Add to dashboard Cite

Aim: Hydatid cyst (HC), which is localized in the liver and lungs in most cases, has been associated with a variety of hematologic and biochemical manifestations. Celiac disease (CD) is a small-intestinal malabsorption syndrome caused by hypersensitivity to gluten in subjects who carry the HLA haplotypes HLA DQ2 and DQ8. This study has attempted to show the connection between CD and HC. Material and Methods: We prospectively analyzed data from 211 HC patients, 62 of whom had extrahepatic involvement of HC; in addition, we also classified the patients' hydatid cysts by their radiologic features. All patients tested positive for HC by ELISA. Sera from the study population were also analyzed for IgA and IgG with ELISA using human recombinant tTG (AESKU. Diagnostics, Germany); the data were then analyzed statistically. Results: Twelve cases of seropositivity of TTG IgA were found among patients with HC. In the control group, the rate of TTG IgG seropositivity was only 2 out of 211 patients (~2%), which was lower than those with HC. In patients with HC, the mean WBC level was higher in patients with TTG IgA seropositivity compared with those without TTG IgA seropositivity. Younger ages were independently associated with TTG IgA seropositivity in the HC group. Conclusion: This study furthers the understanding of CD risk in HC. If confirmed by future studies, the study's data will assist in developing optimal strategies for the detection of CD in patients with HC. Understanding the infectious factors involved in CD is important for identifying new approaches to the early detection of CD.

show abstract

Section: Discussionmentioning

confidence: 97%

Celiac disease prevalence in patients with hydatid cyst

Poyrazoglu¹,

Dönder²,

Dülger³

et al. 2017

J Turgut Ozal Med Cent

View full text Add to dashboard Cite

show abstract

“…One or two decades ago, recurrent abdominal pain was rarely associated with celiac disease and for this presentation, serology screening was not considered to be justified (17). Later, this became one of the frequently seen clinical presentation in Western European countries, North America (6,(18)(19)(20) and other geographical areas (21,22) as a single clinical manifestation or in association with other symptoms. In the study of Khatib that looked at a group of celiac children recently diagnosed (2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013) in United States, abdominal pain was reported in higher percentages than diarrhea, being the most frequent digestive symptom (23).…”

Section: Discussionmentioning

confidence: 99%

“…The first issue remains the identification of cases that require serological screening. Whom to test is yet intensely debated because CD has a heterogenous clinical spectrum and even more, the clinical presentation changed significantly in the last decades: the prevalence of the classical form decreased, while cases with extraintestinal symptoms or less suggestive gastrointestinal symptoms are increasingly more frequent (4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Celiac Disease Case Finding Strategy in Romanian Symptomatic Children

Lešanu¹,

Vlad²,

Becheanu³

et al. 2017

Ro J Pediatr.

View full text Add to dashboard Cite

Objectives. Pediatricians face various challenges in different stages of celiac disease (CD) diagnosis. Whom to test is intensely debated because of CD's heterogenous clinical spectrum. The main purpose of the study was to identify symptoms or symptom associations that should initiate an active strategy of CD early diagnosis in Romanian children. Material and method. We conducted a prospective study in "Grigore Alexandrescu" Emergency Children's Hospital. From March 2013 until February 2014, 249 children with symptoms/signs at risk of CD were included. Results. CD was diagnosed in 11 (1/21 patients evaluated). One in 12.6; 16; 18; 18.5 and 18.5 children respectively with chronic diarrhea, low stature, growth failure, recurrent abdominal pain and constipation had CD. Certain symptom associations increased the risk: classical symptom associations (chronic diarrhea and weight loss), as well as other associations: recurrent abdominal pain and weight loss, constipation and weight loss, constipation and refractory iron deficiency anemia. Conclusion. Active screening among patients with symptoms and especially symptom associations at risk of CD would improve diagnosis rates in pediatric CD.

show abstract

“…In the list provided by NIAMS, 19 of 24 of the autoimmune diseases listed (∼79%) had research linking the disease to pain (Table ). In addition, other autoimmune diseases not listed by the NIAMS, such as Crohn's and celiac diseases, have been linked to pain in the peripheral nervous system (Morrison et al, ; Green et al, ). Multiple studies have also linked increased bodily pain scores in autoimmune diseases with reduced quality of life for patients.…”

Section: Pain In Autoimmune Disordersmentioning

confidence: 99%

Pain in autoimmune disorders

Mifflin

Kerr

2016

J of Neuroscience Research

View full text Add to dashboard Cite

Most autoimmune diseases are associated with pathological pain development. Autoimmune diseases with pathological pain include complex regional pain syndrome, rheumatoid arthritis, and Guillian-Barré syndrome to name a few. The present Review explores research linking the immune system to the development of pathological pain in autoimmune diseases. Pathological pain has been linked to T-cell activation and the release of cytokines from activated microglia in the dorsal horn of the spinal cord. New research on the role of autoantibodies in autoimmunity has generated insights into potential mechanisms of pain associated with autoimmune disease. Autoantibodies may act through various mechanisms in autoimmune disorders. These include the alteration of neuronal excitability via specific antigens such as the voltage-gated potassium channel complexes or by mediating bone destruction in rheumatoid arthritis. Although more research must be done to understand better the role of autoantibodies in autoimmune disease related pain, this may be a promising area of research for new analgesic therapeutic targets. © 2016 Wiley Periodicals, Inc.

show abstract

Clinical Manifestations of Celiac Disease

Cited by 33 publications

References 33 publications

Celiac disease prevalence in patients with hydatid cyst

Celiac disease prevalence in patients with hydatid cyst

Celiac Disease Case Finding Strategy in Romanian Symptomatic Children

Pain in autoimmune disorders

Contact Info

Product

Resources

About