Clinical manifestations of blood cell parameters and inflammatory factors in 92 patients with COVID-19

Deng, Rongrong; Wang, Changzheng; Ye, Yi; Gou, Liyao; Fu, Zhongxiao; Ye, Bo; Shao, Feng; Zhang, Xiaomei; Fu, Weiyang; Xiao, Jianping; Li, Tao; Qi, Huan; Li, Chengbin

doi:10.21037/atm-20-7765

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…It was found that the CRP concentration is almost positively correlated with the degree of inflammation and tissue injury 37 . Many studies have reported that CRP is helpful in the diagnosis of inflammatory diseases, such as neonatal sepsis 38 , COVID-19 39 , pneumonia 40 , and influenza 41 . However, CRP alone cannot distinguish sepsis from SIRS due to its elevated level in both conditions 42 .…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein-to-albumin ratio as a biomarker in patients with sepsis: a novel LASSO-COX based prognostic nomogram

Zhou,

Fu,

et al. 2023

Sci Rep

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To develop a C-reactive protein-to-albumin ratio (CAR)-based nomogram for predicting the risk of in-hospital death in sepsis patients. Sepsis patients were selected from the MIMIC-IV database. Independent predictors were determined by multiple Cox analysis and then integrated to predict survival. The performance of the model was evaluated using the concordance index (C-index), receiver operating characteristic curve (ROC) analysis, and calibration curve. The risk stratifications analysis and subgroup analysis of the model in overall survival (OS) were assessed by Kaplan–Meier (K–M) curves. A total of 6414 sepsis patients were included. C-index of the CAR-based model was 0.917 [standard error (SE): 0.112] for the training set and 0.935 (SE: 0.010) for the validation set. The ROC curve analysis showed that the area under the curve (AUC) of the nomogram was 0.881 in the training set and 0.801 in the validation set. And the calibration curve showed that the nomogram performs well in both the training and validation sets. K–M curves indicated that patients with high CAR had significantly higher in-hospital mortality than those with low CAR. The CAR-based model has considerably high accuracy for predicting the OS of sepsis patients.

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Section: Discussionmentioning

confidence: 99%

C-reactive protein-to-albumin ratio as a biomarker in patients with sepsis: a novel LASSO-COX based prognostic nomogram

Zhou,

Fu,

et al. 2023

Sci Rep

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“…It can be used as an important marker for the diagnosis of infectious diseases. The current CRP assay is diverse, rapid, and inexpensive, so the CRP concentration is used in a regular manner for the diagnosis, differential diagnosis and prognosis of SARS-CoV-2 infection in the management of COVID-19 [12]. In this study, the CRP concentration in the bacteria-positive group was signi cantly higher than that in the bacteria-negative group, suggesting that CRP was signi cantly increased in in ammation caused by bacterial coinfection, but the increase was not signi cant in SARS-CoV-2-positive patients without bacterial coinfection.…”

Section: Discussionmentioning

confidence: 99%

Blood inflammatory markers and cytokines in patients with COVID-19 and bacterial coinfections

Bi,

Zhu,

Zheng

et al. 2023

Preprint

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Background Bacterial coinfection in patients with SARS-CoV-2 infection is an important risk factor for death. This study investigated and analyzed whether there were differences in the levels of serum PCT and CRP and the expression of 12 cytokines, including IL-6, IL-10, IL-2, TNF, and other markers, in patients with SARS-CoV-2 infection combined with bacterial infection compared with those without bacterial infection, aiming to provide references for early clinical diagnosis and empirical treatment. Methods A total of 121 inpatients with SARS-CoV-2 infection admitted to Qingdao Central Hospital from December 7, 2022, to February 7, 2023, were included. Patients were divided into a bacteria-positive group (61 cases) and a bacteria-negative group (60 cases) according to whether they had bacterial infections. PCT, CRP, and 12 cytokines were compared between groups, and the composition of bacterial species in the positive group was statistically analyzed. Results There was no significant difference in the sex ratio or age between the two groups (P > 0.05). The serum levels of CRP (Z = 3.95, P < 0.001), PCT (Z = 3.20, P = 0.001), IL-1β (t = 2.90, P = 0.008), IL-2 (t = 3.83, P = 0.001), IL-12p70 (t = 3.28, P = 0.004), IL-17 (t = 2.22, P = 0.039) and TNF-α (t = 3.02, P = 0.007) between the two groups were significantly different. IL-17 increased more significantly than other markers, while IL-6, IL-8, IL-10, interferon-α, interferon-γ, IL-4 and IL-5 were not statistically significant (P > 0.05). Among the 61 bacteria-positive patients, 27 patients were positive for one species, mainly Staphylococcus aureus, Haemophilus influenzae, and Acinetobacter baumannii. Eleven patients were two species positive, and Acinetobacter baumannii combined with Pseudomonas aeruginosa was common. Fourteen patients were three species positive, and 6 patients were four species positive. Conclusions Serum PCT and CRP levels in SARS-CoV-2-infected patients with bacterial coinfection are higher than those in patients without bacterial infection. Cytokines such as IL-1β, IL-2, IL-12 p70, IL-17, and TNF-α may be involved in the progression of COVID-19 combined with bacterial infection. They can be used as potential markers to evaluate the disease condition and prognosis.

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“…However, analysis at only a single time point may conceal alterations in the parameters of an individual patient when the patient's condition changes, and it may not demonstrate diversification with disease aggravation. Recent studies analyzed a series of large sample cohorts, which included complete data on patients with COVID-19 in different disease states ( 1 , 20 , 22 ); however, there is limited research on dynamic changes in blood cell parameters and inflammatory factors to characterize disease progression and their profiling in the long-term perspective. The immune cells from the peripheral blood of a patient may be used as markers for COVID-19 and can be analyzed using fast and easily accessible blood tests ( 21 , 23 , 24 ).…”

Section: Introductionmentioning

confidence: 99%

Dynamic changes in radiological parameters, immune cells, selected miRNAs, and cytokine levels in peripheral blood of patients with severe COVID‑19

et al. 2023

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The present study aimed to investigate the dynamic changes in peripheral blood leucocyte subpopulations, cytokine and miRNA levels, and changes in computed tomography (CT) scores in patients with severe coronavirus disease 2019 (COVID-19) (n=14) and age-matched non-COVID-19 volunteers (n=17), which were included as a reference control group. All data were collected on the day of patient admission (day 0) and on the 7th, 14th and 28th days of follow-up while CT of the lungs was performed on weeks 2, 8, 24 and 48. On day 0, lymphopenia and leucopenia were detected in most patients with COVID-19, as well as an increase in the percentage of banded neutrophils, B cells, and CD4 + Treg cells, and a decrease in the content of PD-1 low T cells, classical, plasmacytoid, and regulatory dendritic cells. On day 7, the percentage of T and natural killer cells decreased with a concurrent increase in B cells, but returned to the initial level after treatment discharge. The content of different T and dendritic cell subsets among CD45 + cells increased during two weeks and remained elevated, suggesting the activation of an adaptive immune response. The increase of PD-1-positive subpopulations of T and non-T cells and regulatory CD4 T cells in patients with COVID-19 during the observation period suggests the development of an inflammation control mechanism. The levels of interferon γ-induced protein 10 (IP-10), tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 decreased on day 7, but increased again on days 14 and 28. C-reactive protein and granulocyte colony-stimulating factor (G-CSF) levels decreased gradually throughout the observation period. The relative expression levels of microRNA (miR)-21-5p, miR-221-3p, miR-27a-3p, miR-146a-5p, miR-133a-3p, and miR-126-3p were significantly higher at the beginning of hospitalization compared to non-COVID-19 volunteers. The plasma levels of all miRs, except for miR-126-3p, normalized within one week of treatment. At week 48, CT scores were most prominently correlated with the content of lymphocytes, senescent memory T cells, CD127 + T cells and CD57 + T cells, and increased concentrations of G-CSF, IP-10, and macrophage inflammatory protein-1α.

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Clinical manifestations of blood cell parameters and inflammatory factors in 92 patients with COVID-19

Cited by 3 publications

References 13 publications

C-reactive protein-to-albumin ratio as a biomarker in patients with sepsis: a novel LASSO-COX based prognostic nomogram

C-reactive protein-to-albumin ratio as a biomarker in patients with sepsis: a novel LASSO-COX based prognostic nomogram

Blood inflammatory markers and cytokines in patients with COVID-19 and bacterial coinfections

Dynamic changes in radiological parameters, immune cells, selected miRNAs, and cytokine levels in peripheral blood of patients with severe COVID‑19

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