Clinical manifestations and laboratory results of 61 children with infectious mononucleosis

Abstract

Objective To investigate the clinical manifestations of infectious mononucleosis in children of different ages. Methods Clinical data from pediatric patients with infectious mononucleosis admitted from May 2015 to April 2019 were retrospectively analyzed. Patients were stratified into three groups (age 1–3 years, 4–6 years, and 7–14 years) for analysis of clinical and laboratory results. Results Data from 61 patients (male:female ratio 1.18:1) aged 5.15 ± 2.93 years (mean ± standard deviation; range: 1–14 years) were analyzed. Infectious mononucleosis occurred throughout the year and the main clinical manifestations were fever (98.3%), tonsillitis (100%), tonsillar white exudate (83.6%), cervical lymphadenopathy (98.3%), hepatomegaly (37.7%), splenomegaly (42.6%), eyelid edema (41.0%), and nasal obstruction (49.2%). Disease onset was most common during early childhood (37.7%) and at preschool age (37.7%). Younger children had more obvious symptoms of nasal obstruction and older children had more significant elevations of alanine aminotransferase and higher percentages of atypical lymphocytes. Conclusion The clinical manifestations of infectious mononucleosis in children differed by age. These associations required attention for clinical decision making.

Clinical Characteristics and Empirical Research Model of Infectious Mononucleosis Complicated with Mycoplasma pneumoniae or/and Cytomegalovirus Infection

“…In IM children with simple EBV infection, the damage of liver function becomes more and more serious with the increase of age. At present, there are few reports about IM combined with other pathogen infections and grouped by age at home and abroad, and only literatures about IM grouped by age caused by EBV infection also found that ALT significantly increased in older children [20][21][22].…”

Difference between Acyclovir and Ganciclovir in the Treatment of Children with Epstein–Barr Virus-Associated Infectious Mononucleosis

“…Infectious mononucleosis (IM) has a high incidence rate in children, which is often caused by the infection by the herpes family virus Epstein–Barr virus (EBV). The main clinical symptoms include angina, fever, hepatosplenomegaly, and so on [ 1 ]. If not treated in time, the disease easily develops into a malignant disease related to chronic active EBV infection and causes multisystem damage [ 2 ].…”

Tonsil microbiocenosis and salivary lactate dehydrogenase activity in children with infectious mononucleosis

“…За даними Всесвітньої організації охорони здоров'я, захворюваність на герпетичну інфекцію у світі невпинно зростає й охоплює близько 96 % населення планети [1,5,7,10]. Найвищий рівень інфікованості виявлений серед дитячого населення, проте через субклінічний перебіг захворювання не завжди вдається його діагностувати на ранній стадії [2,3].…”

“…У групі 1 рівень загального білірубіну становив 20,1 [16,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]8] мкмоль/л і був вірогідно вищим від аналогічного показника дітей групи 2. Підвищення вмісту загального білірубіну відбувалося за рахунок прямого білірубіну, а рівень непрямого білірубіну в досліджуваних групах відрізнявся незначно і становив 11,9 [10,8-13,2] мкмоль/л у дітей групи 1 і 11,0 [10,[3][4][5][6][7][8][9][10][11]8] мкмоль/л -групи 2. Активність аланінамінотрансферази в дітей групи 1 становила 55,4 [37,2-3,7] Од/л і була вірогідно вищою порівняно з показниками в дітей групи 2 -33,3 [14,2-52,4] Од/л.…”