Clinical manifestations and diagnosis of invasive aspergillosis in immunocompromised children

Abstract

definite, well-timed early diagnosis and sufficient therapy is elementary for a successful outcome of invasive aspergillosis in immunocompromised children. To date, the diagnosis of invasive aspergillosis remains a combination of clinical presentation, radiology and microbiological tests.

Value of lung biopsy in pulmonary diseases in children

“…bone marrow in treating the infection, particularly when it comes to fungal infection especially Aspergillosis, which carry high morbidity and mortality if not treated properly. [14,15] It was also noted in our patient group that the higher morbidity and mortality of patient with those immunocompromised patients.…”

CNS-manifestation of aspergillosis in an extremely low-birth-weight infant

“…Consequently, it is common that the diagnosis is only made by post mortem examination. Therefore, the typical clinical presentation of invasive aspergillosis is persistent clinical signs of infection and/or an elevated CrP despite antibiotic treatment and a clinical presentation with combined pulmonary and cerebral symptoms [17].…”

“…However, invasive aspergillosis has been reported in term and preterm newborns [17]. During the first weeks of life it may present either as a primary cutaneous manifestation or as systemic aspergillosis [6].…”

“…This is particularly true for patients with prolonged and repeated episodes of neutropenia -i.e. after bone marrow transplantation or chemotherapy or immunodeficiency disease such as chronic granulomatous disease -as these conditions predispose the patient to invasive disease [17].…”

Invasive Aspergillosis in Paediatric Patients

“…Whilst IA has been reported in paediatric patients with solid tumours, advanced human immunodeficiency virus (HIV)-infection, chronic destructive lung disease and in severely ill hospitalized neonates, its occurrence in these populations is more of sporadic nature [1,2]. The general epidemiological features of IA in the paediatric population are well reflected by the results of two more recent studies conducted in the United States of America (USA), that have provided the first multi-institutional data ever on the epidemiology and outcome of the disease in paediatric patients [3,4].…”