Clinical Manifestation of Stressful Cardiomyopathy (Takotsubo Syndrome) and the Problem of Differential Diagnosis with Acute Myocardial Infarction

Прокудина, Е С; Kurbatov, Boris K.; Маслов, Л Н

doi:10.18087/cardio.2020.11.n777

Cited by 3 publications

(3 citation statements)

References 141 publications

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“…At present, the gold standard for the diagnosis of AMI is CAG or IVUS (13). However, due to its associated trauma, radioactivity, and high costs, it cannot be used as a routine screening method (14).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of myocardial stress detection based on feature tracking MRI in patients with acute myocardial infarction

Li¹,

Zhao²,

Chen³

et al. 2022

J Thorac Dis

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Background: Evaluate the predictive value of myocardial stress measured by magnetic resonance imaging (MRI) on the severity of coronary artery stenosis and acute myocardial infarction (AMI). In the early stage of acute myocardial infarction, many imaging findings are negative, and MRI myocardial stress detection is controversial in the diagnosis of this aspect. Therefore, it is necessary to determine whether MRI myocardial stress can diagnose acute myocardial infarction.Methods: A total of 120 patients were divided into an AMI group and non-AMI group. The AMI group was further divided into a mild group, moderate group, and severe group. The myocardial stress was measured by MRI, compared in each group, the correlation between myocardial stress and coronary artery stenosis rate was analyzed, and coronary artery disease (CAD) compared between patients with AMI, and the relationship between myocardial stress and AMI was observed.Results: Among the 120 patients, there were 77 cases in the AMI group, including 21 cases in the mild group, 40 cases in the moderate group, and 16 cases in the severe group. There were a total of 43 cases in the non-AMI group. Myocardial stress in the AMI group was significantly higher than that in the non-AMI group (P<0.05). The myocardial stress increased gradually in the mild, moderate, and severe AMI groups (P<0.001). Myocardial stress was positively correlated with coronary artery stenosis rate (P<0.001) and CAD (P<0.05). Logistic regression analysis showed that myocardial stress was an independent risk factor for AMI (P<0.05). The sensitivity and specificity of myocardial stress >5.15 mm in the diagnosis of AMI were 83.5%, 68.6% (AUC =0.834), respectively. Acute myocardial infarction is often caused by risk factors such as hyperlipidemia, hypertension and hyperglycemia, as well as vascular stenosis caused by arterial wall malformation, vascular wall inflammation or vasospasm. Conclusions:The MRI measurement of myocardial stress is simple, reliable, and practical to evaluate the degree of coronary artery lesions. Myocardial stress is closely related to AMI and can assist in the diagnosis of AMI.

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of myocardial stress detection based on feature tracking MRI in patients with acute myocardial infarction

Li¹,

Zhao²,

Chen³

et al. 2022

J Thorac Dis

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“…Acute chest pain, dyspnea, electrocardiographic changes like ST-segment elevation, T-wave inversion, slightly elevated cardiac enzyme levels, and transient ventricular wall motion abnormalities are typical symptoms of acute coronary syndrome. 1 Early imaging is frequently used to distinguish between TTS and acute coronary syndrome, 2 although accuracy needs to be improved.…”

Section: Introductionmentioning

confidence: 99%

Creation of a Rat Takotsubo Syndrome Model and Utilization of Machine Learning Algorithms for Screening Diagnostic Biomarkers

Huai,

Li,

Zhang

et al. 2023

JIR

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Introduction Ferroptosis, a crucial type of programmed cell death, is directly linked to various cardiac disorders. However, the contribution of ferroptosis-related genes (FRGs) to Takotsubo syndrome (TTS) has not been completely understood. Purpose The objective of this study was to investigate the relationship between the FRGs and TTS. Methods TTS rat models were established by isoprenaline injection. Heart tissues were subsequently harvested for total RNA extraction and library construction. Transcriptome data wereobtained transcriptome data for TTS and FRGs from our laboratory, and sources such as the Ferroptosis Database (FerrDb) and the Gene Expression Omnibus Database (GEO). 57 differentially expressed FRGs (DE-FRGs) were discovered. The LASSO and SVM-RFE algorithms were employed to identify Enpp2, Pla2g6, Etv4, and Il1b as marker genes, and logistic regression was applied to construct a diagnostic model. The important genes were validated by real time PCR and the external dataset. Finally, the extent of immune infiltration was explored. Results Among the 57 genes, there were 36 up-regulated and 21 down-regulated genes that exhibited distinct expression patterns in the TTS and healthy control samples. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that the enriched pathways were primarily associated with pathways of neurodegeneration-multiple disease, while Gene Ontology (GO) analysis revealed that these genes were primarily linked to cellular response to external stimuli, outer membrane functions, and ubiquitin protein ligase binding. After the identification of four marker genes as potentially effective biomarkers for TTS diagnosis, subsequent logistic regression modeling revealed a receiver operating characteristic curve (ROC) with an AUC of 1.0. The examination of immune cell infiltration showed significantly higher prevalence of activated CD4 + T cells, mast cells, etc., in TTS. Conclusion Our findings support the theoretical importance of ferroptosis in TTS, highlighting Enpp2, Pla2g6, Etv4, and Il1b as potential diagnostic and therapeutic biomarkers for TTS.

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“…Синдром такоцубо (СТЦ) считается сравнительно редким заболеванием, характеризующийся в первом приближении клиническими проявлениями острого коронарного синдрома [1]. Эхокардиография (ЭхоКГ) -наиболее часто используемый метод выявления СТЦ [2].…”

Section: Introductionunclassified

Myocardial strain changes over a 1-month follow-up in Takotsubo syndrome: a case report

Shirokov,

Kukovskaya,

Malshakov

et al. 2023

Russ J Cardiol

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Among various diagnostic methods, echocardiography (EchoCG) is most often used to identify Takotsubo syndrome. Left ventricular apical ballooning and the absence of permanent local contractility disturbances makes it possible to confirm the diagnosis. Currently, the available literature provides insufficient data on longitudinal strain (LS) of various cardiac chambers in this condition. The current case report demonstrates complete restoration of left heart LS within 1 month with its initial significant decrease.

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Clinical Manifestation of Stressful Cardiomyopathy (Takotsubo Syndrome) and the Problem of Differential Diagnosis with Acute Myocardial Infarction

Cited by 3 publications

References 141 publications

Diagnostic value of myocardial stress detection based on feature tracking MRI in patients with acute myocardial infarction

Diagnostic value of myocardial stress detection based on feature tracking MRI in patients with acute myocardial infarction

Creation of a Rat Takotsubo Syndrome Model and Utilization of Machine Learning Algorithms for Screening Diagnostic Biomarkers

Myocardial strain changes over a 1-month follow-up in Takotsubo syndrome: a case report

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