Clinical manifestation, management and prognosis of clear cell meningioma: an evidence-based review

Rahman, Masum; Dutta, Priyata; Agarwala, Preeti; Ikram, Salma; Ahsan, Eram; Shourav, Manjurul Islam; Riviere-Cazaux, Cecile; Abuleil, Amro; Bhorkar, Aprajita Milind; Reza, Rezaur Rahman; Siddik, Abu Bakar

doi:10.1080/00207454.2021.1956919

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…Spinal CCMs most often occur in the lumbar region, with about one-third of patients having two or more segments involved [ 20 ]. The proportion of patients with involvement of long segments spanning three or more levels has been reported up to 36.9%, in comparison to 2–11% for conventional spinal meningiomas [ 16 ]. Patients with these extended segmental involvements demonstrate a notably elevated recurrence rate [ 22 ].…”

Section: Managementmentioning

confidence: 99%

Clear cell meningiomas—case presentation, review of radiographic identifiers, and treatment approaches

Keymakh,

Benton,

Fluss

et al. 2024

Childs Nerv Syst

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Spinal clear cell meningiomas (CCMs) are a rare histological subtype of meningiomas that post preoperative diagnostic challenges due to their radiographic similarities with other lesions. They are also more aggressive, exhibiting higher rates of recurrence, particularly in pediatric patients. Overcoming diagnostic challenges of these tumors can improve patient outcomes. In this report, we describe a case of a pediatric patient presenting with a lumbar CCM in whom we were able to obtain gross total resection. Our report reviews previously identified predictors of CCM recurrence, including the Ki-67 proliferation index, number of spinal segments involved, and hormonal influences related to age and sex. We describe the characteristic radiographic features that differentiate spinal CCMs from other tumors to improve pre-operative diagnosis. Furthermore, we provide our rationale for adjuvant therapy for pediatric patients to refine treatment protocols for these rare tumors.

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Section: Managementmentioning

confidence: 99%

Clear cell meningiomas—case presentation, review of radiographic identifiers, and treatment approaches

Keymakh,

Benton,

Fluss

et al. 2024

Childs Nerv Syst

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“…Have vacuolated cytoplasm, intercellular microcysts, and low mitotic activity in histological appearance 23,24 Diffusely positive areas for CAIX 25 Clear cell meningioma Oval cells with clear cytoplasm, transparent vacuoles, hyalinized vascular stroma, and rare mitosis related to SMARCE1 mutations 26,27 Positive for EMA vimentin and negative for GFAP, CK7, and S-100 26,28 Papillary meningioma Is more common in younger people 21 Fibroblastic/fibrous meningioma Spindle cell neoplasms that generally lack meningothelial nests and show thick collagen bundles The nuclei of this group retain meningothelial cell characteristics, while whorls and psammoma bodies help exclude schwannoma 29…”

Section: Microcystic Meningiomamentioning

confidence: 99%

“…Oval cells with clear cytoplasm, transparent vacuoles, hyalinized vascular stroma, and rare mitosis related to SMARCE1 mutations 26,27 …”

Section: Introductionmentioning

confidence: 99%

Related mechanisms, current treatments, and new perspectives in meningioma

Inetas‐Yengin,

Bayrak

2024

Genes Chromosomes & Cancer

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Meningiomas are non‐glial tumors that are the most common primary brain tumors in adults. Although meningioma can possibly be cured with surgical excision, variations in atypical/anaplastic meningioma have a high recurrence rate and a poor prognosis. As a result, it is critical to develop novel therapeutic options for high‐grade meningiomas. This review highlights the current histology of meningiomas, prevalent genetic and molecular changes, and the most extensively researched signaling pathways and therapies in meningiomas. It also reviews current clinical studies and novel meningioma treatments, including immunotherapy, microRNAs, cancer stem cell methods, and targeted interventions within the glycolysis pathway. Through the examination of the complex landscape of meningioma biology and the highlighting of promising therapeutic pathways, this review opens the way for future research efforts aimed at improving patient outcomes in this prevalent intracranial tumor entity.

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