Clinical manifestation and prognostic factors of 32 Japanese patients with autoimmune disease-associated diffuse large B-cell lymphoma

Burkitt Lymphoma Preceded by Autoimmune Hemolytic Anemia due to Anti-D Antibody

“…Another possibility is that BL developed due to immune dysregulation and immunosuppressive therapy, however, there has been no previous report of BL associated with an autoimmune condition. The major types of NHL associated with autoimmune conditions include diffuse large B-cell lymphoma, follicular lymphoma, chronic lymphocytic leukemia, small lymphocytic leukemia, marginal zone lymphoma and peripheral T cell lymphoma (8,9). It is therefore difficult to draw the conclusion that immune dysregulation in association with AIHA and immunosuppressive therapy led to BL in our patient.…”

Clinical manifestations of autoimmune disease-related non-Hodgkin lymphoma: a Korean single-center, retrospective clinical study

“…Ten of the 11 patients (91%) had normal karyotypes and the other one patient (9%), diagnosed with plasmablastic lymphoma (patient no. 10), had an abnormal karyotype (45,X,-Y[4]/46,XY[26]). The presence of EBV infection was investigated with the in situ hybridization method on biopsy specimens.…”

“…Over the last several decades, the incidence of lymphoproliferative malignancies has rapidly increased in Caucasian cohorts in many advanced countries [1,2], and these malignancies consist mostly of non-Hodgkin lymphoma (NHL) [1-4]. Although the epidemiology based on immunologic aspects of NHL is not clearly understood, immune dysregulation is speculated to play an important role in lymphomatogenesis on the basis of data showing an increased risk of certain lymphomas in patients following organ transplants or viral infections, in those with primary or acquired immunodeficiencies, and particularly in patients with autoimmune diseases [5].…”

“…Like the immunologic pathophysiology of NHL, autoimmune diseases also comprise a variety of situations based on deregulation of many components of the immune response [6]. Based on those aspects, it has been considered that autoimmune diseases and lymphoproliferative malignancies have a certain relationship, and some studies have reported that autoimmune diseases are implicated in the increased incidence of NHL [4,6-9]. Indeed, a few nation-wide population-based retrospective studies have shown that certain specific autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjogren syndrome have strong relationships with an increased risk of NHL [4,6].…”

“…Several possible explanations for the connection include the role of long-lasting chronic hyper-immune stimulation, treatment with immunosuppressive agents such as methotrexate (MTX), and other shared genetic signals [7,10]. Although large cohort studies regarding the association between autoimmune disease and lymphomas have been reported in Western countries [6,11-13], studies in Asian cohorts have been limited and only a few cases have been reported [4,8,11,12]. Autoimmune disease-related NHL tends to be disregarded because of its minimal incidence and because of the heterogeneous background of lymphoproliferative disease itself in Asian countries.…”