The nicotine metabolite ratio (NMR) has been shown to predict response to the transdermal nicotine patch, such that faster nicotine metabolism is associated with a lower abstinence rate. Menthol cigarette use, vs. non-menthol cigarette use, slows nicotine metabolism and therefore may attenuate the effect of NMR on smoking abstinence. In this study, we evaluated whether cigarette type (menthol vs. non-menthol) modified the association between NMR and short-term abstinence. This was a secondary analysis examining treatment in the first 8 weeks of 21 mg/day nicotine patch therapy in a completed clinical trial (n=474). Menthol cigarette use was based on self-report. NMR was defined dichotomously (0=fast, 1=slow) to distinguish between fast (≥0.47) versus slow NMR. Using logistic regression analysis, we tested whether cigarette type moderated the association between NMR and bioverified 7-day point prevalence abstinence at week 8. Covariates include nicotine dependence, age, race, and sex. 302 participants reported smoking menthol cigarettes, of which 234 (77%) were classified as slow NMR. Among the 172 non-menthol smokers, 136 were classified as slow NMR (79%). Contrary to our expectations, the NMR by cigarette type interaction effect on abstinence was not significant (Odds Ratio [OR]=0.91, p=.86). Excluding the interaction variable, fast NMR was associated with decreased likelihood of abstinence (OR=0.55, p=.03), but menthol cigarette use was not (OR=1.15, p=.56). Further exploration of risk factors among menthol cigarette smokers, especially among racially diverse and light smokers, could clarify the association between menthol cigarette use and poorer smoking outcomes.