Clinical Management of Keratoconus

Lass, Jonathan H.; Lembach, Richard G.; Park, Steve B.; Hom, David L.; Fritz, Mary E.; Svilar, Grace; Nuamah, Isaac; Reinhart, William J.; Stocker, Eric G.; Keates, Richard H.; Moran, Cassandra; Cobo, L. Michael; Foulks, Gary N.

doi:10.1016/s0161-6420(90)32569-1

Cited by 160 publications

(125 citation statements)

References 22 publications

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“…10,11 Comparisons between CLEK and DUSKS is shown in Table 2. The mean age at diagnosis of keratoconus is typically within the second or early third decade of life [11][12][13] (DUSKS and CLEK 2 24 and 27 years old, respectively), although, only a small proportion of keratoconics are newly diagnosed after 40 years of age (DUSKS 7.5%, CLEK 10.1% 2 ).…”

Section: Discussionmentioning

confidence: 99%

The Dundee University Scottish Keratoconus study: demographics, corneal signs, associated diseases, and eye rubbing

Weed

MacEwen

Giles

et al. 2007

Eye

228

164

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Aim To investigate and correlate the corneal, refractive, topographic and familial characteristics of a large cohort with keratoconus. Methods Prospective observational study of 200 consecutive patients presenting with keratoconus during the 4 year-period 1997-2000. Subjects were examined at enrolment and at a final review. Data were collected on demographic characteristics, referral route, symptoms, refractive correction, eye rubbing, family history, medical history, slit-lamp biomicroscopic corneal signs, and computerized corneal topography. Results Mean age at enrolment was 30.9710.4 (range, 12.2-72) years (N ¼ 200, 62.5% male, 93% white Caucasian) with a 5% family history of keratoconus. Atopic diseases included asthma (23%), eczema (14%), and hay fever (30%). Only 9% wore contact lenses before referral. Mean follow-up was 1004 days 7282 (range, 390-1335) and 9.778.9 (range, 1.1-60) years from diagnosis. The mean simulated K1 corneal power at enrolment was 51.7475.36 (range, 42.59-67.32) D and 88.5% exhibited bilateral keratoconus. Fifty-three (15%) topographically confirmed cones exhibited no clinical corneal signs at presentation. At enrollment, 56% had a pachymetry o0.480 mm increasing to 77% at final review. Forty-eight percent of subjects reported significant eye rubbing and there was a highly statistically significant difference (two sample t-test P ¼ 0.018) between keratoconus and control groups. TMS-2 axial corneal power was strongly associated with corneal scarring and age at diagnosis. The size of the scarring effect was 2.2 D (95% confidence interval (CI) 1.34, 3.06). Conclusions This study provides an overview of a large population with keratoconus highlighting presenting features and clinical and topographic progression over a 4 year-period.

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Section: Discussionmentioning

confidence: 99%

The Dundee University Scottish Keratoconus study: demographics, corneal signs, associated diseases, and eye rubbing

Weed

MacEwen

Giles

et al. 2007

Eye

228

164

View full text Add to dashboard Cite

show abstract

“…Vários estudos foram realizados para tentar predizer a progressão ou identificar fatores de risco para transplante. Foram evidenciadas em 1990 que córneas com curvaturas maiores que 50 D e acuidade visual menor que 20/50 são fatores de alto risco para cirurgia, enquanto que sexo, idade e história de atopia são fatores não significativos para a evolução da doença (3) .…”

Section: Ceratocone: Fatores Prognósticosunclassified

“…Alguns autores consideram que o raio da curva base da lente de contato (5) seria o único parâmetro que prediz o transplante, outros consideram (2) que a curvatura da córnea é um fator importante para se determinar os riscos de transplante e alguns caracterizam curvatura (3) maior que 50 D e baixa de visão menor que 20/50.…”

Section: Ii) Cb X Txunclassified

See 1 more Smart Citation

Ceratocone: fatores prognósticos

Elias¹,

Lipener²,

Uras³

et al. 2005

Arq. Bras. Oftalmol.

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“…O tratamento clínico do ceratocone inicia-se pelo uso de óculos, o qual nem sempre é possível, especialmente nos casos em que há astigmatismo irregular e/ou protrusão de grande magnitude (4,5) . Com a progressão da doença, a adaptação de lentes de contato (LC) rígidas pode proporcionar boa visão.…”

Section: Introductionunclassified