Clinical management and infection control of SARS: Lessons learned

Cheng, Vincent Chi-Chung; Chan, Jasper Fuk‐Woo; To, Kelvin Kai-Wang; Yuen, Kwok‐Yung

doi:10.1016/j.antiviral.2013.08.016

Cited by 131 publications

(132 citation statements)

References 147 publications

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“…In a previous review, it was already mentioned that childhood vaccination will become one of the most important applications for disposable inhalers [9]. Also, protection or treatment programmes against threatening infections as, for instance, with H7N9 (bird flu) [87], Severe Acute Respiratory Syndrome (SARS) [88] or Middle East Respiratory Syndrome (MERS) viruses [89], immunisation against bioterrorism agents (e.g., anthrax, plague, tularaemia, botulism and smallpox) [90] or therapies against difficult to cure diseases like MDR and XDR TB [91] may in future be served best with disposable devices. Such applications often start or take place in developing countries with a warm climate where stable dry powders are preferred over wet formulations for reasons discussed in the introduction [92][93][94].…”

Section: Expert Opinionmentioning

confidence: 99%

The role of disposable inhalers in pulmonary drug delivery

Boer¹,

Hagedoorn²

2014

Expert Opinion on Drug Delivery

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Prerequisites for the use of disposable inhalers, particularly dry powder inhalers, in applications such as childhood vaccination and for preventing or stopping pandemic outbreaks of highly infectious diseases (like influenza, bird flu, SARS) are that they are simple, cheap and effective. Not only do the devices have to be simple in design, but the drug formulations should also be cheap. This may require a different approach as the formulation may not need to be adapted to improve the inhaler must be designed to enhance formulation dispersion.

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Section: Expert Opinionmentioning

confidence: 99%

The role of disposable inhalers in pulmonary drug delivery

Boer¹,

Hagedoorn²

2014

Expert Opinion on Drug Delivery

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“…The estimated numbers of common HAI were approximately 93,300 cases of urinary tract infection and 157,500 cases of surgical site infection in 2011(Magill et al., ). In the recent largest outbreak of Middle East Respiratory Syndrome (MERS) in South Korea, Nature reported news on transmission between healthcare workers and patients (Butler, , ), similar to the case of the global spread of severe acute respiratory syndrome (SARS) during 2002–2003 (Chau et al., ; Cheng, Chan, To, & Yuen, ; World Health Organization, ). Visualization techniques using information technology such as infographics may increase awareness and mindfulness among nursing staff of patterns of infectious disease transmission in their workplaces.…”

mentioning

confidence: 91%

Visualization of Data Regarding Infections Using Eye Tracking Techniques

Yoon

Cohen

Cato

et al. 2016

J of Nursing Scholarship

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Objective To evaluate ease of use and usefulness for nurses of visualizations of infectious disease transmission in a hospital. Design An observational study was used to evaluate perceptions of several visualizations of data extracted from electronic health records designed using a participatory approach. Twelve nurses in the master’s program in an urban research-intensive nursing school participated in May 2015. Methods A convergent parallel mixed method was used to evaluate nurses’ perceptions on ease of use and usefulness of five visualization conveying trends in hospital infection transmission applying think-aloud, interview, and eye-tracking techniques. Findings Subjective data from the interview and think-aloud techniques indicated that participants preferred the traditional line graphs in simple data representation due to their familiarity, clarity, and easiness to read. An objective quantitative measure of eye movement analysis (444,421 gaze events) identified a high degree of participants’ attention span in infographics in all three scenarios. All participants responded with the correct answer within 1 min in comprehensive tests. Conclusions A user-centric approach was effective in developing and evaluating visualizations for hospital infection transmission. For the visualizations designed by the users, the participants were easily able to comprehend the infection visualizations on both line graphs and infographics for simple visualization. The findings from the objective comprehension test and eye movement and subjective attitudes support the feasibility of integrating user-centric visualization designs into electronic health records, which may inspire clinicians to be mindful of hospital infection transmission. Future studies are needed to investigate visualizations and motivation, and the effectiveness of visualization on infection rate. Clinical Relevance This study designed visualization images using clinical data from electronic health records applying a user-centric approach. The design insights can be applied for visualizing patient data in electronic health records.

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“…Currently it is unclear if there are additional asymptomatic cases of infection with MERS-CoV. MERS is reminiscent of the outbreak of severe acute respiratory syndrome (SARS) in the Guangdong province in China in 2002-2003 (reviewed in Cheng, Chan, To, & Yuen, 2013). …”

Section: - Introductionmentioning

confidence: 99%

Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors

Kilianski

Baker

2014

Antiviral Research

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To combat the public health threat from emerging coronaviruses (CoV), the development of antiviral therapies with either virus-specific or pan-CoV activities is necessary. An important step in antiviral drug development is the screening of potential inhibitors in cell-based systems. The recent emergence of the Middle East respiratory syndrome (MERS)-CoV necessitates adapting methods that have been used to identify antivirals against the severe, acute respiratory syndrome (SARS)-CoV and developing new approaches to more efficiently screen antiviral drugs. In this article we review cell-based assays using infectious virus (BSL-3) and surrogate assays (BSL-2) that can be implemented to accelerate antiviral development against MERS-CoV and future emergent coronaviruses. This paper forms part of a series of invited articles in Antiviral Research on “From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.”

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Clinical management and infection control of SARS: Lessons learned

Cited by 131 publications

References 147 publications

The role of disposable inhalers in pulmonary drug delivery

The role of disposable inhalers in pulmonary drug delivery

Visualization of Data Regarding Infections Using Eye Tracking Techniques

Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors

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