Clinical-laboratory profile of children and adolescents with multisystem inflammatory syndrome temporarily associated with COVID-19 in Goiás, Brazil

Costa, Mary Alexandra da; Almeida, Robélia Pondé Amorim de; Pondé, Robério Amorim de Almeida

doi:10.1007/s00705-023-05748-z

Cited by 2 publications

(2 citation statements)

References 27 publications

(25 reference statements)

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“…However, our findings are subject to several limitations. First, while our sample size is larger than some of the previous studies, 38,39 it remains relatively small, which may limit the generalizability of our findings and precluded us from performing a more comprehensive, multivariate analysis. Second, we may have overestimated the MIS-C incidence due to underreporting of mild/asymptomatic pediatric COVID-19 cases, especially during the Omicron period when contact tracing was less rigorous.…”

Section: T a B L E 3 (Continued)mentioning

confidence: 88%

Epidemiology, clinical characteristics and outcomes of multisystem inflammatory syndrome in children

Chun‐Ern Ng,

Liew,

Tan

et al. 2023

Pediatrics International

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BackgroundWe describe the epidemiology, clinical characteristics, and outcomes of multisystem inflammatory syndrome in children (MIS‐C) among children from Negeri Sembilan, Malaysia.MethodsA retrospective, multicentre, observational study was performed among children ≤15 years old who were hospitalized for MIS‐C between January 18, 2021 and June 30, 2023. The incidence of MIS‐C was estimated using reported SARS‐CoV‐2 cases and census population data. Descriptive analyses were used to summarize the clinical presentation and outcomes.ResultsThe study included 53 patients with a median age of 5.7 years (IQR 1.8–8.7 years); 75.5% were males. The overall incidence of MIS‐C was approximately 5.9 cases per 1,000,000 person‐months. Pediatric intensive care unit (PICU) admission was required for 22 (41.5%) patients. No mortalities were recorded. Children aged 6–12 years were more likely to present with cardiac dysfunction/shock (odds ratio [OR] 5.43, 95% confidence interval [CI] 1.67–17.66), whereas children below 6 years were more likely to present with a Kawasaki disease phenotype (OR 5.50, 95% CI 1.33–22.75). Twenty patients (37.7%) presented with involvement of at least four organ systems, but four patients (7.5%) demonstrated single‐organ system involvement.ConclusionAn age‐based variation in the clinical presentation of MIS‐C was demonstrated. Our findings suggest MIS‐C could manifest in a spectrum, including single‐organ involvement. Despite the high requirement for PICU admission, the prognosis of MIS‐C was favorable, with no recorded mortalities.

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Section: T a B L E 3 (Continued)mentioning

confidence: 88%

Epidemiology, clinical characteristics and outcomes of multisystem inflammatory syndrome in children

Chun‐Ern Ng,

Liew,

Tan

et al. 2023

Pediatrics International

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“…However, these studies were limited to secondary public domain data (the Ministry of Health’s epidemiological bulletins), had a much lower number of patients, and were restricted to those attending pediatric intensive care units. 14–19…”

Section: Discussionmentioning

confidence: 99%

High Fatality Rates in Pediatric Multisystem Inflammatory Syndrome: A Multicenter Experience From the Epicenter of Brazil’s Coronavirus Pandemic

Almeida,

Jarovsky,

Almeida Farias

et al. 2023

Pediatric Infectious Disease Journal

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Background: Brazil´s case fatality rate (CFR) of pediatric multisystem inflammatory syndrome in children and adolescents (MIS-C) is among the highest worldwide. Despite these concerns, limited hospital-based and comprehensive pediatric data have been published on MIS-C in Brazilian children. Methods: We performed a descriptive analysis of the MIS-C scores in 16 public and private hospitals providing secondary and tertiary care in the metropolitan area of São Paulo, Brazil. Clinical and demographic information were systematically extracted from the electronic medical records of each patient. Logistic regression analysis was performed to identify the combined effects of MIS-C phenotype, disease severity and comorbidity as dependent variables. Results: A total of 101 patients met the MIS-C criteria and were evaluated. The median age was 67 months, 60% were male, 28.7% were black or afrodescendant and 62.3% were admitted to public hospitals. Underlying medical conditions were observed in 16.8% of patients and were associated with a longer duration of hospitalization. A Kawasaki disease-like phenotype was observed in 43.5% of patients, and they demonstrated a trend of lower median age. Children with severe MIS-C were older (median age 91 months vs. 36 months) and had a nonspecific phenotype, more cardiovascular and respiratory involvement and kidney injury; 73.3% required intensive care, 20.8% required mechanical ventilation and 35.6% required inotropic support. Four deaths occurred (CFR = 3.9%), three of which were in healthy participants. Conclusion: We identified a lower median age, particularly among children with Kawasaki disease-like phenotypes, those with a significant need for intensive care, and a high CFR in MIS-C. Our findings confirmed the increased severity of the disease in the selected Brazilian population.

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Clinical-laboratory profile of children and adolescents with multisystem inflammatory syndrome temporarily associated with COVID-19 in Goiás, Brazil

Cited by 2 publications

References 27 publications

Epidemiology, clinical characteristics and outcomes of multisystem inflammatory syndrome in children

Epidemiology, clinical characteristics and outcomes of multisystem inflammatory syndrome in children

High Fatality Rates in Pediatric Multisystem Inflammatory Syndrome: A Multicenter Experience From the Epicenter of Brazil’s Coronavirus Pandemic

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