Clinical-Laboratory Correlation Analysis Among 137 Patients With Raynaud's Phenomenon.

Velayos, Edward E.

doi:10.7326/0003-4819-72-5-782_4

Cited by 3 publications

(4 citation statements)

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“…There is conflict of opinion regarding the association of lower esophageal dysmotility and the presence of Raynaud's phenomenon (5,(21)(22)(23)(24)(25). In the present study, abnormal motility in the distal esophagus was noted in 3 of the 4 patients who had Raynaud's phenomenon, but this was also present in 5 patients who had not experienced Raynaud's phenomenon.…”

Section: Discussionmentioning

confidence: 36%

Esophageal abnormalities and dysphagia in polymyositis and dermatomyositis

Merieux

Verity

Clements

et al. 1983

Arthritis & Rheumatism

112

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Structural or functional abnormalities of the distal esophagus were demonstrated by cineradiography in 14 of 16 patients with polymyositis or dermatomyositis who had been incompletely responsive to high dose corticosteroids and, in some cases, immunosuppressive therapy, or who had adverse effects associated with these therapies. These distal abnormalities occurred in the absence of proximal esophageal skeletal muscle dysfunction in 70% of patients, usually were more frequent with increasing disease duration, and were functionally similar to abnormalities reported in scleroderma. Symptomatic improvement occurred to some patients with administration of antacids and measures designed to decrease esophageal reflux, but improved esophageal symptoms did not correlate with improvement in the myositis. In 18 autopsy subjects with similar histories, distal esophageal smooth muscle atrophy and fibrosis occurred in only 1 and 2 cases, respectively. Of 5 in whom distal esophageal dysmotility had been documented ante-mortem, only 1 had fibrosis and none had smooth muscle atrophy. These findings suggest that factors other than fibrosis and muscle atrophy may contribute to distal esophageal dysmotility in polymyositis and dermatomyositis.

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Section: Discussionmentioning

confidence: 36%

Esophageal abnormalities and dysphagia in polymyositis and dermatomyositis

Merieux

Verity

Clements

et al. 1983

Arthritis & Rheumatism

112

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“…These estimates, however, conflict with prevalence estimates that can be derived from determining the proportion of SSc patients among groups of patients with Raynaud's phenomenon described in the literature (up to 37%) (1 [1][2][3][4][5][6][7][8][9][10][11][12][13][14] and, in turn, from estimating the percentage of RP patients among the general population, believed by several authors to range from 10% to 20% (15)(16)(17)(18)(19). Such calculations yield SSc prevalence rates of approximately 3,000-6,OOO per 100,000, which greatly contrasts with the highest prevalence of 13.8 per 100,000, as cited above (7).…”

mentioning

confidence: 67%

Prevalence of scleroderma spectrum disorders in the general population of south carolina

et al. 1989

Arthritis & Rheumatism

160

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The prevalence of scleroderma spectrum disorders (including systemic sclerosis [SSc] meeting the American Rheumatism Association criteria and the less typical disorders meeting only our study criteria) was determined in a random sample of 6,998 subjects from the general population of South Carolina. The results suggest that the prevalence of these disorders may range from 67 to 265 per 100,000, which is 4.9 to 19.2 times higher than previously reported for definite SSc. The ratio of nondefinite cases to definite cases of SSc (those meeting American Rheumatism Association criteria) was 2.5. Most of the nondefinite cases were unrecognized prior to our study, which suggests the need for improved early diagnosis of scleroderma spectrum dis- orders. Brief histories of the 7 patients with scleroderma spectrum disorders whose cases formed the basis for our calculation of prevalence rates are included in this report.

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“…scleroderma and systemic lupus erythematosus, in which autoimmune mechanisms have also been implicated, are most prominent [14], Raynaud's phenomenon has been reported in two forms of chronic liver disease: (1) as part of the CRST syndrome of scleroderma in a few cases of primary biliary cirrhosis [10. 13], and in a single case of hepatitis B antigen-negative chronic active hepatitis [3], and (2) as a feature accompanying purpura and glomerulonephritis, observed infrequently in patients with cryoglobulinemia and chronic active hepatitis [4,6,15], The absence of purpura, impaired renal function, and failure to demonstrate cryoglobulinemia in our patient suggests that Raynaud's phenomenon may be associated with chronic active hepatitis without the other distinctive features of the cryoglobulinemic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Since its description a century ago, a number of disorders have been linked to the cutaneous alterations, precipitated by cold exposure, known as Ray naud's phenomenon [9,14]. Associated disorders include the connective tissue diseases, cold or mechanical injury, cryoglobulinemia, diabetes mellitus, hypertension, hypothyroidism, occlusive arterial disease, and a variety of central nervous system, thoracic-inlet and infectious illnesses.…”

mentioning

confidence: 99%

Coexistence of Raynaud’s Phenomenon and Chronic Active Hepatitis with Hepatitis B Antigen

Kim¹,

Koff²

1974

Digestion

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A 38-year-old man with onset of Raynaud’s phenomenon 20 years earlier, was found to have asymptomatic chronic active hepatitis with circulating hepatitis B antigen of uncertain duration. No evidence of other disorders known to be associated with Raynaud’s phenomenon was found. Although cer coexistence with chronic active hepatitis in this patient maymerely be fortuitous, it is possible that Raynaud’s phenomenon is an uncommon systemic manifestation of this hepatic disease or an unusual consequence of circulating hepatitis B antigenemia.

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Clinical-Laboratory Correlation Analysis Among 137 Patients With Raynaud's Phenomenon.

Cited by 3 publications

References 0 publications

Esophageal abnormalities and dysphagia in polymyositis and dermatomyositis

Esophageal abnormalities and dysphagia in polymyositis and dermatomyositis

Prevalence of scleroderma spectrum disorders in the general population of south carolina

Coexistence of Raynaud’s Phenomenon and Chronic Active Hepatitis with Hepatitis B Antigen

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