Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection* *Study conducted at Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil.

Bellettini, Camila Vieira; Oliveira, Andressa Welter de; Tusset, Cíntia; Baethgen, Ludmila Fiorenzano; Amantéa, Sérgio L.; Motta, Fabrízio; Gasparotto, Aline; Andreolla, Huander Felipe; Pasqualotto, Alessandro C.

doi:10.1016/s2359-3482(15)30062-2

Cited by 1 publication

(2 citation statements)

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“…In a study by Bellettini et al [20] in Brazil in which the researchers examined 222 of suspected pertussis-related individuals from September 2011 to January 2013, 72.5% of the subjects were reported to have pertussis which 60.9% of them were under one year of age. The researchers then have proposed that cyanosis among children younger than 6 months could be considered as an independent predictor of pertussis.…”

Section: Discussionmentioning

confidence: 99%

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Seroepidemiology of pertussis in a set of under one year old Iranian children

Badamchi

Siadat

Shahcheraghi

2019

vacres

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Introduction: Pertussis or whooping cough is one of the vaccine preventable diseases. The purpose of this study was to evaluate the seroepidemiology of pertussis in two groups of children (i.e. under 2 months and 2-12 months old) who had been admitted to Tehran Children Hospital. Methods: Sampling from the children was done along with completing a questionnaire including demographic information, clinical symptoms and the history of the parents coughing. The levels of IgG-Ptx antibody were then measured using the children's sera. Results: Overall, 10.8% of the children were not immune, 78.3% were immune, and 10.9% had recent pertussis infections. Moreover, 19.4% of the female and 13.1% of the male subjects had the infection. In the age group less than two months, 16.6% were infected. The likelihood of new infection among the children less than 2 months old was 1.2 times higher than the control group (P < 0.004). Fifty percent of the children who were diagnosed with cyanosis in their clinical examinations had a recent infection (P <0.001). Conclusion: Pertussis appears to be endemic in Iran with children under one year old being at high risk of the infection. In this regard, maternal vaccination against pertussis for conferring passive immunity to the newborns could be considered as a protection measure.

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Section: Discussionmentioning

confidence: 99%

“…6 No. 1 pertussis studies have reported that 92.2% anti-Ptx IgG sensitivity by ELISA for serologic diagnosis of pertussis [21,20]. Comparison of anti-Ptx IgG with antibodies against other pertussis vaccine antigens have indicated that antigens other than PT have low sensitivity [12].…”

Section: Discussionmentioning

confidence: 99%